Combination Therapy with Immune Checkpoint Inhibitors and Histone Deacetylase Inhibitors or Alkylating Agents. [PDF]
Cancer Manag ResJoerger M +3 more
europepmc +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, EarlyView.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
Effects of different alkylating agents on photoreceptor degeneration and proliferative response of Müller glia. [PDF]
Sci RepNomura-Komoike K, Nishino R, Fujieda H.
europepmc +1 more source
European Journal of Organic Chemistry, EarlyView.A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados +1 more
wiley +1 more source
Perception of infertility risk vs. objective fertility status in males exposed to alkylating agents but not radiation therapy: a report from the St. Jude Lifetime (SJLIFE) cohort study. [PDF]
J Cancer SurvivWare ME +15 more
europepmc +1 more source
Flow Synthesis of Muscone‐Macrocycles Using the Eschenmoser Rearrangement as a Key Step
Helvetica Chimica Acta, EarlyView.A two‐step flow process, comprising the formation of hydrazones followed by Eschenmoser fragmentation, enables the efficient synthesis of macrocyclic ketones, which serve as precursors for exaltone and muscone. ABSTRACT Hydrazone formation followed by Eschenmoser fragmentation are key steps in the synthesis of muscone‐type macrocycles.
Merlin Hauer +6 more
wiley +1 more source
Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome
International Journal of Cancer, EarlyView.ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin +10 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To characterize anti‐Müllerian hormone (AMH) recovery after multiagent chemotherapy for high‐risk gestational trophoblastic neoplasia (GTN) and evaluate the impact of regimen and hysterectomy. Methods This was a retrospective cohort of 68 high‐risk GTN patients treated with EMA/CO (etoposide, methotrexate, actinomycin D ...
Wei Xue +8 more
wiley +1 more source
Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients. [PDF]
Hum Reprod OpenCui Y +18 more
europepmc +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol +4 more
wiley +1 more source