Results 161 to 170 of about 1,549,035 (266)

Readily Accessible bTurea‐Derived Nitroxide Polarizing Agents for Dynamic Nuclear Polarization: bcTCOOKs and bcTmols

Chemistry – A European Journal, EarlyView.
Two families of bTurea‐derived biradicals, bcTmols and bcTCOOKs, were prepared as polarizing agents for dynamic nuclear polarization (DNP)‐enhanced NMR through short and efficient synthetic routes. The best‐performing biradical, bcTCOOK‐M2, containing two methyl groups on the urea bridge, provided signal enhancements of up to ∼220 at 14.1 T and 100 K ...
Ancy T. Wilson, Shubha S. Gunaga, Frederic Mentink‐Vigier, Snorri Th. Sigurdsson   +3 more
wiley   +1 more source

Alkylating agents-induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front. [PDF]

Clin Transl Sci
Sriram S, Macedo T, Mavinkurve-Groothuis A, van de Wetering M, Looijenga LHJ.   +4 more
europepmc   +1 more source

Si(OTeF5)4 – A Strong, Homoleptic Pentafluoroorthotellurate‐Based Lewis Superacidic Silane

Chemistry – A European Journal, EarlyView.
The homoleptic pentafluoroorthotellurate‐based silane Si(OTeF5)4 was synthesized and fully characterized via spectroscopic techniques. The Lewis superacidic properties were investigated theoretically as well as experimentally and its utilization as a Lewis acid is demonstrated by the reaction with nitrogen bases.
Friederike Oesten, Niklas Limberg, Anja Wiesner, Simon Steinhauer, Lukas Fischer, Sebastian Riedel   +5 more
wiley   +1 more source

Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents. [PDF]

Neuro Oncol
Lang F, Cornwell JA, Kaur K, Elmogazy O, Zhang W, Zhang M, Song H, Sun Z, Wu X, Aladjem MI, Aregger M, Cappell SD, Yang C.   +12 more
europepmc   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents. [PDF]

Acta Neuropathol Commun, 2021
Siller S, Lauseker M, Karschnia P, Niyazi M, Eigenbrod S, Giese A, Tonn JC.   +6 more
europepmc   +1 more source

Asymmetric Synthesis of Tertiary α‐Aryl Stereocentres in Tetrahydro‐4H‐pyran‐4‐ones Using Pd‐Catalyzed Decarboxylative Asymmetric Protonation

European Journal of Organic Chemistry, EarlyView.
The Pd‐catalyzed decarboxylative asymmetric protonation (DAP) has been developed for sterically hindered tetrahydro‐4H‐pyran‐4‐one derived α‐aryl‐β‐keto esters. A substrate scope of nine examples of DAP showed that substrates containing a di‐ortho methoxy substitution pattern on the aryl ring gave rise to the highest enantioselectivities of up to 85 ...
Fionn McNeill, Joffrey Scriven, Fritz Bahns, Anugam V. Krishna, Julia Bruno‐Colmenarez, Patrick J. Guiry   +5 more
wiley   +1 more source

Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy. [PDF]

Curr Protoc
Bhatt D, Sundaram RK, López KSL, Lee T, Gueble SE, Vasquez JC.   +5 more
europepmc   +1 more source

A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents. [PDF]

Cancer Res, 2020
Sapkota Y, Wilson CL, Zaidi AK, Moon W, Fon Tacer K, Lu L, Liu Q, Baedke J, Dhaduk R, Wang Z, Chemaitilly W, Krasin MJ, Berry FB, Zhang J, Hudson MM, Robison LL, Green DM, Yasui Y.   +17 more
europepmc   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, EarlyView.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source