Results 141 to 150 of about 51,251 (261)

Photoactivatable V-Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G-quadruplex Alkylating Agents. [PDF]

Chemistry, 2022
Lena A, Benassi A, Stasi M, Saint-Pierre C, Freccero M, Gasparutto D, Bombard S, Doria F, Verga D.   +8 more
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells. [PDF]

Oncotarget, 2022
Valdez BC, Murray D, Yuan B, Nieto Y, Popat U, Andersson BS.   +5 more
europepmc   +1 more source

Bis(2‐Adamantyl)Magnesium: Synthesis, Structure, and Applications of a Versatile and Shelf‐Stable 2‐Adamantyl Anion Equivalent

Chemistry – A European Journal, EarlyView.
At last, the long‐sought bis(2‐adamantyl)magnesium reagent has been prepared in high yield as a stable tetrahydrofuran/dioxane adduct and fully characterized by x‐ray crystallography. This potent nucleophile outperforms the corresponding Grignard in transmetallation and carbonyl addition reactions, opening new avenues in adamantyl organometallic and ...
Matthew V. DaCosta, Fioralba Taullaj, Jack H. Lin, Ulrich Fekl   +3 more
wiley   +1 more source

Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp²)-H Alkylation Using Nitroalkanes as Alkylating Agents. [PDF]

J Am Chem Soc, 2022
Chandra Mallojjala S, Sarkar R, Karugu RW, Manna MS, Ray S, Mukherjee S, Hirschi JS.   +6 more
europepmc   +1 more source

Cellular Membrane‐Targeted Europium(III) Probe for Selective and Time‐Resolved Detection of Peroxynitrite

Chemistry – A European Journal, EarlyView.
We report a cellular membrane‐targeted europium(III) probe, Eu.Chol, that enables selective, time‐resolved detection of peroxynitrite (ONOO−) at the cell membrane interface. Eu.Chol demonstrates efficient incorporation into liposomes and Jurkat cells, with minimal response to H2O2, establishing a modular platform for subcellular ONOO− sensing ...
Jamie Webb, Rebecca Tiffany, Karolis Norvaisa, Hennie Valkenier, Lea Miebach, Sander Bekeschus, Stephen J. Butler   +6 more
wiley   +1 more source

[Retracted] The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK‑p53‑dependent mitochondrial apoptosis in breast cancer cells. [PDF]

Int J Oncol, 2022
Zhao L, Li Y, He M, Song Z, Lin S, Yu Z, Bai X, Wang E, Wei M.   +8 more
europepmc   +1 more source

Clinical Impact of Maximum Plasma Concentration of Busulfan in Pediatric Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Busulfan's narrow therapeutic index and high pharmacokinetic (PK) variability warrant investigation of its exposure–toxicity relationship. We retrospectively analyzed 334 pediatric and young adult patients who underwent allogeneic hematopoietic stem cell transplantation at Seoul National University Children's Hospital between 2009 and 2020 and received
Sungyeun Bae, Jung Yoon Choi, Kyung Taek Hong, Bo Kyung Kim, Hyun Jin Park, Kyung‐Sang Yu, Su‐jin Rhee, Hyoung Jin Kang   +7 more
wiley   +1 more source

Alkylboronic acids as alkylating agents: photoredox-catalyzed alkylation reactions assisted by K₃PO₄. [PDF]

Chem Sci, 2022
Yue F, Ma H, Song H, Liu Y, Dong J, Wang Q.   +5 more
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source