Results 141 to 150 of about 81,731 (287)

Memory of Chirality in Radical Addition–Translocation–Cyclization Cascades

Helvetica Chimica Acta, EarlyView.
Radical addition–translocation–cyclization cascades of chiral alkynes show striking memory of chirality (MoC), with strong retention of configuration when fast, polarity favored cyclization are involved. The most effective system employs a highly electron‐poor pentafluorobenzenesulfonyl group.
Christian Simon Gloor, Fabrice Dénès, Valentin Soulard, Philippe Renaud   +3 more
wiley   +1 more source

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. [PDF]

, 2000
A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse.
Albright, RE, Brada, M, Bruner, J, Fink, K, Fredericks, R, Friedman, H, Glantz, M, Greenberg, H, Hohl, RJ, Levin, VA, Olson, J, Osoba, D, Phillips, P, Prados, MD, Rampling, R, Selker, RG, Shapiro, W, Spence, A, Vick, NA, Yue, N, Yung, WK, Zaknoen, S   +21 more
core  

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Photoactivatable V-Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G-quadruplex Alkylating Agents. [PDF]

Chemistry, 2022
Lena A, Benassi A, Stasi M, Saint-Pierre C, Freccero M, Gasparutto D, Bombard S, Doria F, Verga D.   +8 more
europepmc   +1 more source

Real‐world effectiveness and safety with nivolumab plus ipilimumab or nivolumab alone in patients with or without melanoma brain metastasis: Results from the German noninterventional NICO study

International Journal of Cancer, EarlyView.
What's New? Although patients with melanoma brain metastases (MBM) may benefit from treatment with immune checkpoint inhibitors (ICIs), which are known to improve survival in advanced melanoma, MBM patients have often been excluded from trials evaluating ICIs.
Ralf Gutzmer, Michael Weichenthal, Thomas Eigentler, Peter Mohr, Thomas Sickmann, Pia Dücker, Christoffer Gebhardt, Sebastian Haferkamp, Katharina C. Kähler, Friedegund Meier, Claudia Pföhler, Anca Sindrilaru, Patrick Terheyden, Imke von Wasielewski, Selma Ugurel, Jens Ulrich, Jochen Utikal, Carsten Weishaupt, Dirk Schadendorf   +18 more
wiley   +1 more source

ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells. [PDF]

Oncotarget, 2022
Valdez BC, Murray D, Yuan B, Nieto Y, Popat U, Andersson BS.   +5 more
europepmc   +1 more source

alkylating agent

Citation: 'alkylating agent' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15454 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Efficacy and Safety Profile of a Rituximab, Methotrexate, and Thiotepa‐Based Regimen in Newly Diagnosed Primary CNS Lymphoma

International Journal of Cancer, EarlyView.
Primary central nervous system diffuse large B‐cell lymphoma (PCNS‐DLBCL) lacks an optimal first‐line induction strategy, particularly for older patients and those ineligible for intensive consolidation. In this retrospective cohort of 36 newly diagnosed patients, the rituximab + methotrexate + thiotepa (RMT) regimen as first‐line induction achieved ...
Haotian Wang, Jia Li, Luming Cao, Ying Zhang, Xin Wan, Xingtong Wang, Yangzhi Zhao, Zhaoxia Li, Chengqian Chen, Yang Song, Ou Bai   +10 more
wiley   +1 more source

Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp²)-H Alkylation Using Nitroalkanes as Alkylating Agents. [PDF]

J Am Chem Soc, 2022
Chandra Mallojjala S, Sarkar R, Karugu RW, Manna MS, Ray S, Mukherjee S, Hirschi JS.   +6 more
europepmc   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source