Results 131 to 140 of about 51,251 (261)
Chemistry – A European Journal, EarlyView.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles. [PDF]
Angew Chem Int Ed Engl, 2022 Cox L +5 more
europepmc +1 more source
Helical Folding of Abiotic Chiral Poly(phosphodiester)s
Chemistry – A European Journal, EarlyView.Design and structural analysis of a new class of phosphodiester foldamers are presented. These oligomers that fold into single helical architecture showed length and temperature stability dependence comparable to DNA duplexes. ABSTRACT Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence
Ranajit Barman +3 more
wiley +1 more source
Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents. [PDF]
BMC Pregnancy Childbirth, 2023 Liu F +5 more
europepmc +1 more source
Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release
Chemistry – A European Journal, EarlyView.Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source
Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation. [PDF]
Angew Chem Int Ed Engl, 2022 Wang JZ, Sakai HA, MacMillan DWC.
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers. [PDF]
Angew Chem Int Ed Engl, 2022 Schilling D +5 more
europepmc +1 more source
Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker
Chemistry – A European Journal, EarlyView.ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo +2 more
wiley +1 more source
Control of Gemcitabine Activity With Blue and Red Light
Chemistry – A European Journal, EarlyView.Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten +6 more
wiley +1 more source