Results 111 to 120 of about 51,251 (261)

Update on non-infectious uveitis treatment: anti-TNF-alpha and beyond

Frontiers in Ophthalmology
Non-infectious uveitis (NIU) encompasses a range of conditions marked by inflammation within various layers of the eye. NIU is a significant contributor to irreversible vision loss among the working-age population in developed countries.
Khushboo Chauhan, Khushboo Chauhan, Mudit Tyagi, Mudit Tyagi   +3 more
doaj   +1 more source

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles

Journal of Lipid Research, 2012
We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the accumulation of 5,6α-epoxy-cholesterol (5,6α-EC) and ...
Michael R. Paillasse, Nathalie Saffon, Heinz Gornitzka, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina   +5 more
doaj   +1 more source

Combination of computerized morphonuclear and multivariate analyses to characterize in vitro the antineoplastic effect of alkylating agents. [PDF]

, 1995
The influence of 13 anticancer alkylating agents on cell proliferation, cell cycle parameters, and morphonuclear characteristics was monitored in vitro on three neoplastic cell lines.
Atassi, Ghanem, Pauwels, O, Kiss, Robert, Olivier Pauwels, Robert Kiss, Ghanem Atassi   +5 more
core   +1 more source

Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones

Green Synthesis and Catalysis
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high yield.
Ke-Li Wang, Hong-Tao Ji, Qiong-Hui Peng, Jun Jiang, Li-Juan Ou, Wei-Min He   +5 more
doaj   +1 more source

Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction

Química Nova, 2005
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis ...
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes   +5 more
doaj   +1 more source

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source

Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation

Angewandte Chemie International Edition, EarlyView.
A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

Temozolomide-Induced Myelodysplasia

Advances in Hematology, 2010
A patient who had received temozolomide (TMZ) as a single agent in treatment of malignant glioma developed therapy-induced myelodysplasia (T-MDS). TMZ is an orally active imidazotetrazine which methylates guanine residues in DNA, ultimately causing ...
Ethan A. Natelson, David Pyatt
doaj   +1 more source

Developmental toxicity of alkylating agents in differentiating cell cultures [PDF]

, 1996
Thesis (Ph. D.)--University of Washington, 1996Alkylating agents are well known carcinogens and teratogens. Highest exposures occur in occupational settings, although other lifestyle factors also contribute to exposure. The four alkylating agents used in
Seeley, Marguerite R
core  

CHRONIC LYMPHOCYTIC LEUKEMIA ASSOCIATED WITH NEPHROTIC SYNDROME

Turkish Journal of Nephrology, 2019
Chronic Lymphocytic Leukemia (CLL) is a hematologic neoplasm characterized by the accumulation mature-appearing lymphocytes in the peripheral blood associated with infiltration of the bone marrow, spleen, lymph nodes and occasionally other organs ...
T.Rıfkı EVRENKAYA, E. Murat ATASOYU, E. Gökhan KANDEMİR, Ahmet ÖZTÜRK, M. Yaşar TÜLBEK   +4 more
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