Results 101 to 110 of about 46,126 (242)

Helical Folding of Abiotic Chiral Poly(phosphodiester)s

Chemistry – A European Journal, EarlyView.
Design and structural analysis of a new class of phosphodiester foldamers are presented. These oligomers that fold into single helical architecture showed length and temperature stability dependence comparable to DNA duplexes. ABSTRACT Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence
Ranajit Barman, Brice Kauffmann, Jean‐François Lutz, Victor Maurizot   +3 more
wiley   +1 more source

Photoactivatable V-Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G-quadruplex Alkylating Agents. [PDF]

Chemistry, 2022
Lena A, Benassi A, Stasi M, Saint-Pierre C, Freccero M, Gasparutto D, Bombard S, Doria F, Verga D.   +8 more
europepmc   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells. [PDF]

Oncotarget, 2022
Valdez BC, Murray D, Yuan B, Nieto Y, Popat U, Andersson BS.   +5 more
europepmc   +1 more source

Clinical Impact of Maximum Plasma Concentration of Busulfan in Pediatric Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Busulfan's narrow therapeutic index and high pharmacokinetic (PK) variability warrant investigation of its exposure–toxicity relationship. We retrospectively analyzed 334 pediatric and young adult patients who underwent allogeneic hematopoietic stem cell transplantation at Seoul National University Children's Hospital between 2009 and 2020 and received
Sungyeun Bae, Jung Yoon Choi, Kyung Taek Hong, Bo Kyung Kim, Hyun Jin Park, Kyung‐Sang Yu, Su‐jin Rhee, Hyoung Jin Kang   +7 more
wiley   +1 more source

Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp²)-H Alkylation Using Nitroalkanes as Alkylating Agents. [PDF]

J Am Chem Soc, 2022
Chandra Mallojjala S, Sarkar R, Karugu RW, Manna MS, Ray S, Mukherjee S, Hirschi JS.   +6 more
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

The Evolving Role of Alkylating Agents in Multiple Myeloma: From the Past and Present to Next-Generation Peptide Drug Conjugates

healthbook TIMES. Oncology Hematology
Despite significant recent advances in treatment with small molecules, inhibitor, antibodies and immunotherapy, multiple myeloma (MM) remains an incurable malignancy characterized by high rates of relapse. Alkylating agents, a cornerstone of MM treatment,
Yuxin Liu, Shahrier Hossain, Omar Nadeem, Shonali Midha, Monique Hartley-Brown, Taya Salman, Pedro Vianna, Adam S. Sperling, Giada Bianchi, Clifton Mo, Jacob Laubach, Paul G. Richardson   +11 more
doaj   +1 more source

[Retracted] The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK‑p53‑dependent mitochondrial apoptosis in breast cancer cells. [PDF]

Int J Oncol, 2022
Zhao L, Li Y, He M, Song Z, Lin S, Yu Z, Bai X, Wang E, Wei M.   +8 more
europepmc   +1 more source

Detection of the GH Analogue Redalsomatropin Alfa in Sports Drug Testing: Immunological Approaches and LC‐HRMS/MS

Drug Testing and Analysis, EarlyView.
After evaluating the compatibility of the GH analogue redalsomatropin alfa with approved doping control immunoassays for rhGH, it was implemented into the existing detection method for somatrogon employing affinity purification with GHR‐Fc‐conjugated magnetic beads, tryptic digestion, and LC‐HRMS/MS to allow for a specific and sensitive detection ...
Katja Walpurgis, Andreas Thomas, Jasmin Thelen, Bettina Majer, Maneera Al‐Jaber, Wadha Abushareeda, Mario Thevis   +6 more
wiley   +1 more source