Results 121 to 130 of about 1,549,035 (266)

Charge Transfer Mechanism for Carcinogenesis by Alkylating and Other Agents

, 1986
This study was undertaken as an outgrowth of the oxy radical-iminium theory of carcinogenesis. A conjugated iminium species is thought to act in certain cases as a charge transfer entity resulting in the generation of oxy radicals which attack DNA.
Peter Kovacic, Michael D. Ryan, Ryan, Michael D., Nelson, Victor C., Philip W. Crawford, Victor C. Nelson, Crawford, Philip W., Kovacic, Peter   +7 more
core   +1 more source

Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control

Nature Communications
Regioselective arene C−H bond alkylation is a powerful tool in synthetic chemistry, yet subject to many challenges. Herein, we report the meta-C−H bond alkylation of aromatics bearing N-directing groups using (hetero)aromatic epoxides as alkylating ...
Peng-Bo Bai, Alastair Durie, Gang-Wei Wang, Igor Larrosa   +3 more
doaj   +1 more source

Therapeutic advances of rituximab alone or plus other drugs for membranous nephropathy

Linchuang shenzangbing zazhi
Membranous nephropathy （MN） is a common pathological type of adult nephrotic syndrome. According to the etiology, MN is divided into idiopathic membranous nephropathy （IMN） and secondary membranous nephropathy （SMN）.
Chao Zhang, Hui Liao, Rong-shan Li
doaj   +1 more source

NAD⁺ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents. [PDF]

Cells, 2023
Ruszkiewicz J, Papatheodorou Y, Jäck N, Melzig J, Eble F, Pirker A, Thomann M, Haberer A, Rothmiller S, Bürkle A, Mangerich A.   +10 more
europepmc   +1 more source

alkylating agent

Citation: 'alkylating agent' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15454 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans. [PDF]

Cells, 2023
Ruszkiewicz J, Endig L, Güver E, Bürkle A, Mangerich A.   +4 more
europepmc   +1 more source

Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles. [PDF]

Angew Chem Int Ed Engl, 2022
Cox L, Zhu Y, Smith PJ, Christensen KE, Sidera Portela M, Donohoe TJ.   +5 more
europepmc   +1 more source

Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents. [PDF]

BMC Pregnancy Childbirth, 2023
Liu F, Wan Q, Liu P, Miao D, Dai X, Chen L.   +5 more
europepmc   +1 more source

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

Angewandte Chemie International Edition, EarlyView.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation. [PDF]

Angew Chem Int Ed Engl, 2022
Wang JZ, Sakai HA, MacMillan DWC.
europepmc   +1 more source