Results 121 to 130 of about 51,251 (261)
Arthritis &Rheumatology, EarlyView.Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan +12 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Nature CommunicationsRegioselective arene C−H bond alkylation is a powerful tool in synthetic chemistry, yet subject to many challenges. Herein, we report the meta-C−H bond alkylation of aromatics bearing N-directing groups using (hetero)aromatic epoxides as alkylating ...
Peng-Bo Bai +3 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino +6 more
wiley +1 more source
The mechanism, structure and energetics of DNA damage induced by alkylating agents and ionizing radiation. [PDF]
, 1998 The mechanism, structure and energetics of DNA damage induced by alkylating agents and ionizing ...
O. U. N. Harshica. Fernando (7954664)
core
Therapeutic advances of rituximab alone or plus other drugs for membranous nephropathy
Linchuang shenzangbing zazhiMembranous nephropathy （MN） is a common pathological type of adult nephrotic syndrome. According to the etiology, MN is divided into idiopathic membranous nephropathy （IMN） and secondary membranous nephropathy （SMN）.
Chao Zhang, Hui Liao, Rong-shan Li
doaj +1 more source
NAD+ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents. [PDF]
Cells, 2023 Ruszkiewicz J +10 more
europepmc +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A series of thirteen (N‐heterocyclic carbene) NHC‐stabilized borenium cations is synthesized from NHC→BH3 complexes via hydroboration and condensation with diols. The novel compounds are fully characterized. Eight crystal structures are presented. Kinetic and NMR data show how the structural features translate to catalytic activity in hydrosilylation ...
Michał Jakubczyk +4 more
wiley +1 more source
Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans. [PDF]
Cells, 2023 Ruszkiewicz J +4 more
europepmc +1 more source