Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans. [PDF]
Cells, 2023 Ruszkiewicz J +4 more
europepmc +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, EarlyView.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles. [PDF]
Angew Chem Int Ed Engl, 2022 Cox L +5 more
europepmc +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents. [PDF]
BMC Pregnancy Childbirth, 2023 Liu F +5 more
europepmc +1 more source
Expedient Discovery of a Metallaphotoredox Cyanomethylation for Synthesizing α‐Aryl Nitriles
Chemistry – A European Journal, EarlyView.A metallaphotoredox cyanomethylation reaction has been developed for the synthesis of valuable α‐aryl nitrile intermediates. The methodology was successfully applied to diverse medicinally‐relevant substrates, providing an expedient route to anti‐cancer Senexin compounds, while also removing the need for toxic cyanide reagents. The mechanism was probed
Gemma C. Cook +6 more
wiley +1 more source
Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation. [PDF]
Angew Chem Int Ed Engl, 2022 Wang JZ, Sakai HA, MacMillan DWC.
europepmc +1 more source
Chemistry – A European Journal, EarlyView.A series of thirteen (N‐heterocyclic carbene) NHC‐stabilized borenium cations is synthesized from NHC→BH3 complexes via hydroboration and condensation with diols. The novel compounds are fully characterized. Eight crystal structures are presented. Kinetic and NMR data show how the structural features translate to catalytic activity in hydrosilylation ...
Michał Jakubczyk +4 more
wiley +1 more source
Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers. [PDF]
Angew Chem Int Ed Engl, 2022 Schilling D +5 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source