Results 71 to 80 of about 46,126 (242)

Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69

Biomedicines, 2019
Temozolomide, a DNA methylating drug, is currently being used first-line in glioblastoma therapy. Although the mode of action of this so-called SN1 alkylating agent is well described, including the types of induced DNA damage triggering the DNA damage ...
Bernd Kaina
doaj   +1 more source

2-(4-(2-Chloroacetamido)-1-methyl-1H-pyrrole-2-carboxamido)ethyl Acetate

Molbank, 2014
The title compound 2-(4-(2-chloroacetamido)-1-methyl-1H-pyrrole-2-carboxamido)ethyl acetate was synthesized. The structure of the compound was fully characterized by 1H-NMR, 13C-NMR and mass spectral analysis.
Naim H. Al-Said
doaj   +1 more source

O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma

Radiation Oncology, 2012
Background Gene silencing of O6-methylguanine–DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation.
Jakob Jens, Hille Maren, Sauer Christian, Ströbel Philipp, Wenz Frederik, Hohenberger Peter   +5 more
doaj   +1 more source

Update on non-infectious uveitis treatment: anti-TNF-alpha and beyond

Frontiers in Ophthalmology
Non-infectious uveitis (NIU) encompasses a range of conditions marked by inflammation within various layers of the eye. NIU is a significant contributor to irreversible vision loss among the working-age population in developed countries.
Khushboo Chauhan, Khushboo Chauhan, Mudit Tyagi, Mudit Tyagi   +3 more
doaj   +1 more source

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles

Journal of Lipid Research, 2012
We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the accumulation of 5,6α-epoxy-cholesterol (5,6α-EC) and ...
Michael R. Paillasse, Nathalie Saffon, Heinz Gornitzka, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina   +5 more
doaj   +1 more source

Recent advances in photocatalytic hydrogen peroxide production

PhotoMat, EarlyView., 2023
We classify the representative photocatalytic materials for photosynthesis of hydrogen peroxide (H2O2) in recent years and discuss the related modification methods in detail, providing inspiration and insights for the future design of photocatalysts for H2O2 production.
Jinyu Yan, Yuan Li, Yunxiang Li, Shuxin Ouyang, Tierui Zhang   +4 more
wiley   +1 more source

Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones

Green Synthesis and Catalysis
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high yield.
Ke-Li Wang, Hong-Tao Ji, Qiong-Hui Peng, Jun Jiang, Li-Juan Ou, Wei-Min He   +5 more
doaj   +1 more source

Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction

Química Nova, 2005
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis ...
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes   +5 more
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Temozolomide-Induced Myelodysplasia

Advances in Hematology, 2010
A patient who had received temozolomide (TMZ) as a single agent in treatment of malignant glioma developed therapy-induced myelodysplasia (T-MDS). TMZ is an orally active imidazotetrazine which methylates guanine residues in DNA, ultimately causing ...
Ethan A. Natelson, David Pyatt
doaj   +1 more source