Results 71 to 80 of about 51,251 (261)
Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
Short story of antirheumatic therapy.VIII. The immunodepressants
Reumatismo, 2012 The use of immunosuppressive drugs in rheumatology is fairly recent, starting just after the Second World War with the introduction of the first alkylating agents in oncohematology.
P. Marson, G. Pasero
doaj +1 more source
Advanced Science, EarlyView.HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang +10 more
wiley +1 more source
Charge Transfer Mechanism for Carcinogenesis by Alkylating and Other Agents [PDF]
, 1986 This study was undertaken as an outgrowth of the oxy radical-iminium theory of carcinogenesis. A conjugated iminium species is thought to act in certain cases as a charge transfer entity resulting in the generation of oxy radicals which attack DNA.
Peter Kovacic +7 more
core +1 more source
Advanced Science, EarlyView.Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn +12 more
wiley +1 more source
Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair. [PDF]
, 2010 Methylmethane sulphonate (MMS), an S(N)2-type alkylating agent, generates DNA methylated bases exhibiting cytotoxic and mutagenic properties. Such damaged bases can be removed by a system of base excision repair (BER) and by oxidative DNA demethylation ...
Sikora, Anna +11 more
core +1 more source
All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species
Advanced Science, EarlyView.A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao +8 more
wiley +1 more source
Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death [PDF]
, 2017 Muhammad Saif Ur Rahman,1 Ling Zhang,2 Lingyan Wu,1 Yuqiong Xie,1 Chunchun Li,1 Jiang Cao1 1Clinical Research Center, 2Cardiovascular Key Laboratory of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou ...
Wu LY +5 more
core
Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing [PDF]
, 2018 Drugs that covalently modify DNA are components of most chemotherapy regimens, often serving as first‐line treatments. Classically, the reactivity and selectivity of DNA alkylating agents has been determined in vitro with short oligonucleotides.
Gillingham, Dennis +3 more
core +1 more source
Bipyridyl ligands as mildly activable mono- and bis-alkylating agents capable of DNA cross-linking [PDF]
, 2007 The photoactivation of 6,6′-bis-CH2X-[2,2′]bipyridinyl-5,5′-diol ligands as mono and bis-alkylating agents has been investigated, detecting transient heterocyclic quinone ...
RICHTER, SARA +4 more
core +3 more sources