Results 61 to 70 of about 1,549,035 (266)

Oligoethylene Glycol Side‐Chain Engineering of Y6‐Derived Nonfullerene Acceptors for Thermally Induced Spontaneous Pseudo‐Planar Heterojunction Organic Photodetectors

Advanced Functional Materials, EarlyView.
OEG‐functionalized Y6‐derived acceptors induce thermally driven vertical phase separation, enabling pseudo‐planar heterojunction organic photodetectors. The resulting PM6:YTEG‐4F and PM6:YTEG‐4Cl organic photodetectors suppress dark current density by approximately 260‐fold and 210‐fold, respectively, while maintaining efficient photoresponse ...
Se Jeong Park, Sang Young Jeong, Yunji Eom, Yelim Kang, Yeonsu Choi, Seunghyun Rhee, Bo Ram Lee, Bong Joo Kang, Nam Joong Jeon, Jae Won Shim, Han Young Woo, Seo‐Jin Ko   +11 more
wiley   +1 more source

The clinical pharmacology of alkylating agents in high-dose chemotherapy

, 2000
Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient ...
Smits, K. D., Mathôt, R. A., Beijnen, J. H., Rodenhuis, S., Schellens, J. H., Huitema, A. D.   +5 more
core   +1 more source

Selected Alkylating Agents Can Overcome Drug Tolerance of G-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice. [PDF]

, 2017
We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse.We studied responses to various mono- and bifunctional alkylating agents in a genetically engineered mouse model for ...
Ariena Kersbergen, Blatter, Sohvi, Küçükosmanoğlu, Aslı, Rottenberg, Sven, Wendy Sol, Küçükosmanoğlu, Aslι, Sohvi Blatter, Sven Rottenberg, Kersbergen, Ariena, Sol, Wendy, Piet Borst, Pajic, Marina, Gonggrijp, Maaike, Jonkers, Jos, Guyader, Charlotte, Charlotte Guyader, Aslι Küçükosmanoğlu, Blatter, Sohvi Tuulikki, Maaike Gonggrijp, Drost, Rinske, Rinske Drost, Marina Pajic, Jos Jonkers, Borst, Piet   +23 more
core   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Restoration of Sensitivity in Chemo [PDF]

, 2013
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the prognosis remains poor and relapse occurs regularly.
Schäfer, Andrea, Morfill, Gregor E., Schwenk-Zieger, Sabina, Shimizu, Tetsuji, Welz, Christian, Li, Yang-Fang, Boxhammer, Veronika, Zimmermann, Julia L., Klämpfl, Tobias G., Köritzer, Julia, Schlegel, Jürgen   +10 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents

, 2015
4-(4-Nitrobenzyl)­pyridine (NBP) is a colorimetric indicator compound for many types of carcinogenic alkylating agents. Because of the similar reactivity of NBP and guanine in DNA, NBP serves as a DNA model.
Jennifer A. Love (1393678), Philip A. Provencher (1519930)   +1 more
core   +1 more source

Replication-linked histone acetylation in rat liver tissue is sensitive to alkylating agents [PDF]

, 1990
The effect of alkylating agents on histone acetyltransferase (EC 2.3.1.48) activity and thymidine incorporation was investigated in benign and malignant proliferating rat liver tissue and compared with the effect in normal non-proliferating rat liver ...
Talasz, Heribert, Günter Weiss, Bernd Puschendorf, Weiss, Günter, Heribert Talasz, Puschendorf, Bernd   +5 more
core   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source