Results 41 to 50 of about 1,549,035 (266)
Alkylating Agents Stronger than Alkyl Triflates
, 2016 A new class of potent electrophilic “R+ ” alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB11Me5X6) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions with ...
Jens Geier (2479777) +4 more
core +2 more sources
Journal of Saudi Chemical Society, 2017 The combination of two pharmacological entities in a single compound has been utilized as a promising drug design strategy for site-specificity. So two nitrogen mustard agents were synthesized by conjugating mustard with the benzodiazepine nucleus in the
Rajesh K. Singh +2 more
doaj +1 more source
Bio-triggered triazenes : a novel approach to release alkylating agents
, 2022 Glioblastoma multiforme (GBM) is the most prevalent and invasive type of glioma, and patients present a median survival time of only 14 months after diagnosis.
Braga, Cláudia Marisa Fernandes
core
Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier +18 more
wiley +1 more source
Revista Brasileira de Hematologia e Hemoterapia, 2005 A leucemia linfóide crônica (LLC-B) é uma neoplasia de comportamento indolente, que o tratamento imediato não mostrou vantagem em prolongar a sobrevida dos pacientes em estádios iniciais.
Carlos S. Chiattone
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Molecules, 2021 Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic +5 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mutagenic damage to mammalian cells by therapeutic alkylating agents
, 1996 Cytotoxic alkylating agents used as therapeutics include nitrogen mustards, ethyleneimines, alkyl sulfonates, nitrosoureas and triazenes. Their reactivity with DNA, RNA and proteins can cause cell death.
Alison J. Shield +3 more
core +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source