Results 31 to 40 of about 1,549,035 (266)
Carcinogenicity of Alkylating Agents [PDF]
Public Health Reports (1896-1970), 1966 T O A CHEMIST interested in carcinogenesis, one of its fascinating aspects is the great variety of chemicals that after being administered to a test animal can lead to cancer. Some very simple molecules, that is, carbon tetrachloride or diazomethane, are carcinogenic in certain species of animals while in others only complex structures are cancer ...
openaire +2 more sources
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. [PDF]
PLoS ONE, 2011 First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis ...
Steve Quiros +2 more
doaj +1 more source
Combination chemotherapy with anticancer agents and OK-432 [PDF]
, 1974 Antitumor effects of the combination chemotherapy with hemolytic streptococcus preparation, OK-432, and various anticancer agents were observed on experimental tumors and human cancers.
Sugiyama, Motoharu +6 more
core +1 more source
Monocytosis and Multiple Myeloma: treatment-related acute leukaemia?
Surgical and Experimental Pathology, 2022 Background Therapy-related acute monocytic leukemias in patients with plasma cell dyscrasias are infrequent. Case presentation We here present a case of a 60 year old female who developed an acute monocytic leukemia two years after the diagnosis of ...
Cristina Veronica Trinidad Esparza +4 more
doaj +1 more source
Docking analysis of aryl derivatives of diepoxide alkylating agents
Pakistan Journal of Pharmaceutical Sciences, 2020 In this research, molecular structural manipulation of treosulfan alkylating agent and resultant changes in binding is studied to assist in designing derivatives of treosulfan for synthesis.
Hamdullah Khadim Sheikh +3 more
doaj +1 more source
Mechanisms of chemoresistance to alkylating agents in malignant glioma [PDF]
, 2008 Intrinsic or acquired chemoresistance to alkylating agents is a major cause of treatment failure in patients with malignant brain tumors. Alkylating agents, the mainstay of treatment for brain tumors, damage the DNA and induce apoptosis, but the ...
Weller, M +6 more
core +1 more source
Polyphenols enhance the activity of alkylating agents in leukaemia cell lines. [PDF]
Oncotarget, 2019 Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin, and induce apoptosis and/or cell-cycle arrest. Here, we assess the effects of five polyphenols alone and in combination with three alkylating agents: cisplatin,
Mahbub AA +4 more
europepmc +2 more sources
Alkylating Agents Stronger than Alkyl Triflates [PDF]
, 2004 A new class of potent electrophilic "R(+)" alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB(11)Me(5)X(6)) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions ...
Stoyanov, Evgenii +9 more
core +1 more source
DNA Damaging Agents in Chemical Biology and Cancer
CHIMIA, 2020 Despite their toxicity, DNA alkylating drugs remain a cornerstone of anticancer therapy. The classical thinking was that rapidly dividing tumour cells left more of its DNA in an exposed single-stranded state, making these rapidly dividing cells more ...
Basilius Sauter, Dennis Gillingham
doaj +1 more source
Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents. [PDF]
Cancer Discov, 2019 © 2019 American Association for Cancer Research. The extraordinary activity of high-dose cyclophosphamide against some high-grade lymphomas was described nearly 60 years ago.
Lossos C +23 more
europepmc +2 more sources