Results 31 to 40 of about 51,251 (261)

The clinical pharmacology of alkylating agents in high-dose chemotherapy [PDF]

, 2000
Alkylating agents are widely used in high-dose chemotherapy regimens in combination with hematological support. Knowledge about the pharmacokinetics and pharmacodynamics of these agents administered in high doses is critical for the safe and efficient ...
Smits, K. D., Mathôt, R. A., Beijnen, J. H., Rodenhuis, S., Schellens, J. H., Huitema, A. D.   +5 more
core   +1 more source

Design, synthesis and in vitro cytotoxicity study of benzodiazepine-mustard conjugates as potential brain anticancer agents

Journal of Saudi Chemical Society, 2017
The combination of two pharmacological entities in a single compound has been utilized as a promising drug design strategy for site-specificity. So two nitrogen mustard agents were synthesized by conjugating mustard with the benzodiazepine nucleus in the
Rajesh K. Singh, D.N. Prasad, T.R. Bhardwaj   +2 more
doaj   +1 more source

Reactivity Modulation of Reactive OFF–ON Type G‑Quadruplex Alkylating Agents [PDF]

, 2022
Alkylating agents for nucleic acids have been widely used in cancer chemotherapy, as well as in chemical biology for strong inhibitors and tagging methods.
Fumi Nagatsugi (1802146), Madoka E. Hazemi (9578114), Kazumitsu Onizuka (1802143), Yutong Chen (7486346)   +3 more
core   +1 more source

Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents [PDF]

, 2015
4-(4-Nitrobenzyl)­pyridine (NBP) is a colorimetric indicator compound for many types of carcinogenic alkylating agents. Because of the similar reactivity of NBP and guanine in DNA, NBP serves as a DNA model.
Jennifer A. Love (1393678), Philip A. Provencher (1519930)   +1 more
core   +1 more source

Secondary 3‐Chloropiperidines: Powerful Alkylating Agents

ChemistryOpen
In previous works, we demonstrated that tertiary 3‐chloropiperidines are potent chemotherapeutics, alkylating the DNA through the formation of bicyclic aziridinium ions. Herein, we report the synthesis of novel secondary 3‐chloropiperidine analogues. The
Mats Georg, Dr. Lina Alexandra Laping, Veronica Billo, Prof. Dr. Barbara Gatto, Prof. Dr. Peter Friedhoff, Prof. Dr. Richard Göttlich   +5 more
doaj   +1 more source

Tratamento de primeira linha da leucemia linfóide crônica Chronic lymphocytic leukemia: first line treatment

Revista Brasileira de Hematologia e Hemoterapia, 2005
A leucemia linfóide crônica (LLC-B) é uma neoplasia de comportamento indolente, que o tratamento imediato não mostrou vantagem em prolongar a sobrevida dos pacientes em estádios iniciais.
Carlos S. Chiattone
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Selected Alkylating Agents Can Overcome Drug Tolerance of G-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice. [PDF]

, 2017
We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse.We studied responses to various mono- and bifunctional alkylating agents in a genetically engineered mouse model for ...
Ariena Kersbergen, Blatter, Sohvi, Küçükosmanoğlu, Aslı, Rottenberg, Sven, Wendy Sol, Küçükosmanoğlu, Aslι, Sohvi Blatter, Sven Rottenberg, Kersbergen, Ariena, Sol, Wendy, Piet Borst, Pajic, Marina, Gonggrijp, Maaike, Jonkers, Jos, Guyader, Charlotte, Charlotte Guyader, Aslι Küçükosmanoğlu, Blatter, Sohvi Tuulikki, Maaike Gonggrijp, Drost, Rinske, Rinske Drost, Marina Pajic, Jos Jonkers, Borst, Piet   +23 more
core   +1 more source

Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: Preclinical and clinical data [PDF]

, 2021
Seizures are relatively common in cancer patients, and co-administration of chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many cases.
Cucchiara F., Luci G., Ferraro S., Bocci G.   +3 more
core   +1 more source

Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein

Molecules, 2021
Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic, Giulia Olivato, Caterina Carraro, Richard Göttlich, Dan Fabris, Barbara Gatto   +5 more
doaj   +1 more source