Results 31 to 40 of about 81,731 (287)

XPS Characterization of Friedel-Crafts Cross-Linked Polystyrene [PDF]

, 2001
The combination of a difunctional alkylating agent, either hydroxymethylbenzyl chloride or α,α′-dichloroxylene with polystyrene or high-impact polystyrene together with a Friedel-Crafts catalyst, 2-ethylhexyldiphenylphosphate, and an amine to react with ...
Du, Jianxin, Wang, Jiangqi, Wilkie, Charles A., Yao, Hongyang   +3 more
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Design, synthesis and in vitro cytotoxicity study of benzodiazepine-mustard conjugates as potential brain anticancer agents

Journal of Saudi Chemical Society, 2017
The combination of two pharmacological entities in a single compound has been utilized as a promising drug design strategy for site-specificity. So two nitrogen mustard agents were synthesized by conjugating mustard with the benzodiazepine nucleus in the
Rajesh K. Singh, D.N. Prasad, T.R. Bhardwaj   +2 more
doaj   +1 more source

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H., Henderson, Colin J., MacLeod, A. Kenneth, McLaughlin, Lesley A., McMahon, Michael, Wolf, C. Roland   +5 more
core   +9 more sources

Surface-Modified Polymeric Nanoparticles for Glioblastoma Therapy: A Review on Targeting Strategies and Delivery of Repurposed Drugs and Off-Label Non-Alkylating Agents

Pharmaceutics
Glioblastoma (GBM) remains the most aggressive primary brain tumor, with poor outcomes under the current standard-of-care with temozolomide (TMZ). Therapeutic failure is multifactorial, mainly driven by TMZ resistance mediated by DNA repair enzymes (MGMT)
Daniela Maria Sousa, Joana Angélica Loureiro, Maria Carmo Pereira, Maria João Ramalho   +3 more
doaj   +1 more source

Tratamento de primeira linha da leucemia linfóide crônica Chronic lymphocytic leukemia: first line treatment

Revista Brasileira de Hematologia e Hemoterapia, 2005
A leucemia linfóide crônica (LLC-B) é uma neoplasia de comportamento indolente, que o tratamento imediato não mostrou vantagem em prolongar a sobrevida dos pacientes em estádios iniciais.
Carlos S. Chiattone
doaj   +1 more source

The potential role and application of PARP inhibitors in cancer treatment [PDF]

, 2009
Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core   +2 more sources

Secondary 3‐Chloropiperidines: Powerful Alkylating Agents

ChemistryOpen
In previous works, we demonstrated that tertiary 3‐chloropiperidines are potent chemotherapeutics, alkylating the DNA through the formation of bicyclic aziridinium ions. Herein, we report the synthesis of novel secondary 3‐chloropiperidine analogues. The
Mats Georg, Dr. Lina Alexandra Laping, Veronica Billo, Prof. Dr. Barbara Gatto, Prof. Dr. Peter Friedhoff, Prof. Dr. Richard Göttlich   +5 more
doaj   +1 more source

Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein

Molecules, 2021
Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic, Giulia Olivato, Caterina Carraro, Richard Göttlich, Dan Fabris, Barbara Gatto   +5 more
doaj   +1 more source

Initiation of Olefin Metathesis: Reaction of Deca-2,8-diene with Catalysts formed from Me_4Sn-WC1_6 and Me_3Al_2Cl_3-(Ph_3P)_2(NO)_2Cl_2Mo [PDF]

, 1977
The initial product of the metathesis of deca-2,8-diene with metathesis catalysts formed from either Me_4Sn–WCl_6 or Me_3Al_2Cl_3–(Ph_3P)_2(NO)_2Cl_2Mo is propene; labelling of the terminal groups of the diene and the alkylating agents gives a labelling ...
Grubbs, Robert H., Hoppin, Charles R.
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