Results 11 to 20 of about 46,126 (242)
Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. [PDF]
PLoS Genetics, 2013 Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues.
Jennifer A Calvo +10 more
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Biosynthesis of DNA-Alkylating Antitumor Natural Products
Molecules, 2022 DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highly active ...
Qiu-Yue Nie +3 more
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Cell Reports, 2015 Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang +10 more
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Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. [PDF]
PLoS ONE, 2011 First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis ...
Steve Quiros +2 more
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Carcinogenicity of Alkylating Agents [PDF]
Public Health Reports (1896-1970), 1966 T O A CHEMIST interested in carcinogenesis, one of its fascinating aspects is the great variety of chemicals that after being administered to a test animal can lead to cancer. Some very simple molecules, that is, carbon tetrachloride or diazomethane, are carcinogenic in certain species of animals while in others only complex structures are cancer ...
openaire +2 more sources
Effect of curcumin on the genotoxicity induced by alkylating agents
Frontiers in Genetics, 2015 The protection of the structure of DNA is extremly important to transfer genetic information from generation to generation. DNA damage due to genotoxic ess is an important type of stress which organisms are exposed during their life.
İbrahim Hakkı Ciğerci
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Monocytosis and Multiple Myeloma: treatment-related acute leukaemia?
Surgical and Experimental Pathology, 2022 Background Therapy-related acute monocytic leukemias in patients with plasma cell dyscrasias are infrequent. Case presentation We here present a case of a 60 year old female who developed an acute monocytic leukemia two years after the diagnosis of ...
Cristina Veronica Trinidad Esparza +4 more
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Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids [PDF]
Nucleic Acids Research, 2019 Kazumitsu Onizuka +2 more
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DNA Damage Induced by Alkylating Agents and Repair Pathways
Journal of Nucleic Acids, 2010 The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms.
Natsuko Kondo +3 more
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DNA Damaging Agents in Chemical Biology and Cancer
CHIMIA, 2020 Despite their toxicity, DNA alkylating drugs remain a cornerstone of anticancer therapy. The classical thinking was that rapidly dividing tumour cells left more of its DNA in an exposed single-stranded state, making these rapidly dividing cells more ...
Basilius Sauter, Dennis Gillingham
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