Balancing repair and tolerance of DNA damage caused by alkylating agents [PDF]
Nature Reviews Cancer, 2012 Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage.
A Al-Attar +211 more
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Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
doaj +1 more source
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]
, 2001 Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M. +9 more
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Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. [PDF]
PLoS Genetics, 2013 Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues.
Jennifer A Calvo +10 more
doaj +1 more source
Biosynthesis of DNA-Alkylating Antitumor Natural Products
Molecules, 2022 DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highly active ...
Qiu-Yue Nie +3 more
doaj +1 more source
Cell Reports, 2015 Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang +10 more
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Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. [PDF]
PLoS ONE, 2011 First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis ...
Steve Quiros +2 more
doaj +1 more source
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases [PDF]
, 2000 The cloning, purification, and characterization of MagIII, a 3-methyladenine DNA glycosylase from Helicobacter pylori, is presented in this paper. Sequence analysis of the genome of this pathogen failed to identify open reading frames potentially coding ...
Boiteux, Serge +5 more
core +1 more source
Effect of curcumin on the genotoxicity induced by alkylating agents
Frontiers in Genetics, 2015 The protection of the structure of DNA is extremly important to transfer genetic information from generation to generation. DNA damage due to genotoxic ess is an important type of stress which organisms are exposed during their life.
İbrahim Hakkı Ciğerci
doaj +1 more source