Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents [PDF]
Neoplasia: An International Journal for Oncology ResearchThe ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano +12 more
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Temozolomide and Other Alkylating Agents in Glioblastoma Therapy [PDF]
Biomedicines, 2019 The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly aggressive and lethal primary brain tumor.
Hannah Strobel +7 more
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Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents [PDF]
Frontiers in EndocrinologyBackgroundRecent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging.
Xiaohui Lu +8 more
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Surface-Modified Polymeric Nanoparticles for Glioblastoma Therapy: A Review on Targeting Strategies and Delivery of Repurposed Drugs and Off-Label Non-Alkylating Agents [PDF]
PharmaceuticsGlioblastoma (GBM) remains the most aggressive primary brain tumor, with poor outcomes under the current standard-of-care with temozolomide (TMZ). Therapeutic failure is multifactorial, mainly driven by TMZ resistance mediated by DNA repair enzymes (MGMT)
Daniela Maria Sousa +3 more
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Alkylating agents activate an SLFN11-dependent vulnerability that confers PARP-1 inhibitor sensitivity in kidney cancer [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground PARP inhibitors have demonstrated notable clinical benefit, particularly in tumors with BRCA1/2 mutations. Clear cell renal cell carcinoma (ccRCC) carrying wild type (WT) BRCA1/2 is resistant to PARP inhibitor monotherapy.
Chenliang Wang +6 more
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Secondary 3‐Chloropiperidines: Powerful Alkylating Agents [PDF]
ChemistryOpenIn previous works, we demonstrated that tertiary 3‐chloropiperidines are potent chemotherapeutics, alkylating the DNA through the formation of bicyclic aziridinium ions. Herein, we report the synthesis of novel secondary 3‐chloropiperidine analogues. The
Mats Georg +5 more
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In Situ Evaluation of the GSH Depletion Ability of Various Alkylating Agents and the Protective Effect of Several Active Thiol Compounds Based on High-Content Cell Analysis [PDF]
ToxicsThe depletion degree of reduced glutathione is a critical indicator for assessing the toxicity of alkylating agents. In the present research, we have developed a novel method to evaluate the glutathione (GSH) depletion induced by a series of alkylating ...
Jing Guo +7 more
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Effect of curcumin on the genotoxicity induced by alkylating agents
Frontiers in Genetics, 2015 The protection of the structure of DNA is extremly important to transfer genetic information from generation to generation. DNA damage due to genotoxic ess is an important type of stress which organisms are exposed during their life.
İbrahim Hakkı Ciğerci
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Non‐alkylating agents‐induced gonadotoxicity in pre‐pubertal males: Insights on the clinical and pre‐clinical front [PDF]
Clinical and Translational ScienceWhilst chemotherapy regimens have proven to be more successful for pediatric cancer patients over the years, their influence on long‐term side effects is relatively poorly understood.
Sruthi Sriram +4 more
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DNA Damage Induced by Alkylating Agents and Repair Pathways [PDF]
Journal of Nucleic Acids, 2010 The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms.
Natsuko Kondo +3 more
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