Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents [PDF]
Neoplasia: An International Journal for Oncology ResearchThe ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano +12 more
doaj +5 more sources
Surface-Modified Polymeric Nanoparticles for Glioblastoma Therapy: A Review on Targeting Strategies and Delivery of Repurposed Drugs and Off-Label Non-Alkylating Agents [PDF]
PharmaceuticsGlioblastoma (GBM) remains the most aggressive primary brain tumor, with poor outcomes under the current standard-of-care with temozolomide (TMZ). Therapeutic failure is multifactorial, mainly driven by TMZ resistance mediated by DNA repair enzymes (MGMT)
Daniela Maria Sousa +3 more
doaj +2 more sources
Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents [PDF]
Frontiers in EndocrinologyBackgroundRecent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging.
Xiaohui Lu +8 more
doaj +2 more sources
In Situ Evaluation of the GSH Depletion Ability of Various Alkylating Agents and the Protective Effect of Several Active Thiol Compounds Based on High-Content Cell Analysis [PDF]
ToxicsThe depletion degree of reduced glutathione is a critical indicator for assessing the toxicity of alkylating agents. In the present research, we have developed a novel method to evaluate the glutathione (GSH) depletion induced by a series of alkylating ...
Jing Guo +7 more
doaj +2 more sources
Non‐alkylating agents‐induced gonadotoxicity in pre‐pubertal males: Insights on the clinical and pre‐clinical front [PDF]
Clinical and Translational ScienceWhilst chemotherapy regimens have proven to be more successful for pediatric cancer patients over the years, their influence on long‐term side effects is relatively poorly understood.
Sruthi Sriram +4 more
doaj +2 more sources
Novel Pathways of Oxidative and Nitrosative Inactivation of the Human MGMT Protein in Colon Cancer and Glioblastoma Cells: Increased Efficacy of Alkylating Agents In Vitro and In Vivo [PDF]
DiseasesBackground: O6-Methylguanine-DNA methyltransferase (MGMT) is a unique antimutagenic DNA repair protein that plays a crucial role in conferring resistance to various alkylating agents in brain tumor therapy.
Debasish Basak +3 more
doaj +2 more sources
Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer [PDF]
Frontiers in Oncology, 2022 Exposure to alkylating agents and radiation may cause damage and apoptosis in cancer cells. Meanwhile, this exposure involves resistance and leads to metabolic reprogramming to benefit cancer cells.
Yu-Chan Chang +10 more
doaj +2 more sources
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy [PDF]
Biomedicines, 2019 The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly aggressive and lethal primary brain tumor.
Hannah Strobel +7 more
doaj +2 more sources
Evolution of Nitrogen-Based Alkylating Anticancer Agents [PDF]
, 2021 Despite the significant progress in anticancer drug development over recent years, there is a vital need for newer agents with unique, but still effective, mechanisms of action in order to treat the disease, particularly the highly aggressive and drug ...
Fredrik Lehmann, Johan Wennerberg
core +1 more source
Mutation signatures specific to DNA alkylating agents in yeast and cancers. [PDF]
Nucleic Acids Res, 2020 Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (SN1 and SN2) are still unclear ...
Saini N +8 more
europepmc +3 more sources