MPTAC links alkylation damage signaling to sterol biosynthesis
Redox Biology, 2022 Overproduction of reactive oxygen species (ROS) drives inflammation and mutagenesis. However, the role of the DNA damage response in immune responses remains largely unknown.
Tamaki Suganuma, Jerry L. Workman
doaj +1 more source
Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
doaj +1 more source
Single-Molecule Force Spectroscopy of Deoxyribonucleic Acid and Deoxyribonucleic Acid Polymerase Activity Impacted by Alkylating Agents [PDF]
, 2023 DNA alkylating agents are widely used in anticancer pharmacology. Although shown to induce cross-linking and/or methylation of DNA, how they affect the mechanical properties of DNA and activity of DNA enzymes remains to be elucidated.
Shipeng Hao (15557427) +31 more
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Alkylating Agents Stronger than Alkyl Triflates [PDF]
, 2016 A new class of potent electrophilic “R+ ” alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB11Me5X6) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions with ...
Jens Geier (2479777) +4 more
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Polyphenols enhance the activity of alkylating agents in leukaemia cell lines. [PDF]
Oncotarget, 2019 Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin, and induce apoptosis and/or cell-cycle arrest. Here, we assess the effects of five polyphenols alone and in combination with three alkylating agents: cisplatin,
Mahbub AA +4 more
europepmc +3 more sources
Combination chemotherapy with anticancer agents and OK-432 [PDF]
, 1974 Antitumor effects of the combination chemotherapy with hemolytic streptococcus preparation, OK-432, and various anticancer agents were observed on experimental tumors and human cancers.
Sugiyama, Motoharu +6 more
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Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents. [PDF]
Cancer Discov, 2019 © 2019 American Association for Cancer Research. The extraordinary activity of high-dose cyclophosphamide against some high-grade lymphomas was described nearly 60 years ago.
Lossos C +23 more
europepmc +2 more sources
Mutagenic damage to mammalian cells by therapeutic alkylating agents [PDF]
, 1996 Cytotoxic alkylating agents used as therapeutics include nitrogen mustards, ethyleneimines, alkyl sulfonates, nitrosoureas and triazenes. Their reactivity with DNA, RNA and proteins can cause cell death.
Alison J. Shield +3 more
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Mechanisms of chemoresistance to alkylating agents in malignant glioma [PDF]
, 2008 Intrinsic or acquired chemoresistance to alkylating agents is a major cause of treatment failure in patients with malignant brain tumors. Alkylating agents, the mainstay of treatment for brain tumors, damage the DNA and induce apoptosis, but the ...
Weller, M +6 more
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Alkylating Agents Stronger than Alkyl Triflates [PDF]
, 2004 A new class of potent electrophilic "R(+)" alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB(11)Me(5)X(6)) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions ...
Stoyanov, Evgenii +9 more
core +1 more source