Novel Pathways of Oxidative and Nitrosative Inactivation of the Human MGMT Protein in Colon Cancer and Glioblastoma Cells: Increased Efficacy of Alkylating Agents In Vitro and In Vivo [PDF]
DiseasesBackground: O6-Methylguanine-DNA methyltransferase (MGMT) is a unique antimutagenic DNA repair protein that plays a crucial role in conferring resistance to various alkylating agents in brain tumor therapy.
Debasish Basak +3 more
doaj +2 more sources
Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer [PDF]
Frontiers in Oncology, 2022 Exposure to alkylating agents and radiation may cause damage and apoptosis in cancer cells. Meanwhile, this exposure involves resistance and leads to metabolic reprogramming to benefit cancer cells.
Yu-Chan Chang +10 more
doaj +2 more sources
Alkylating derivatives of oestrogens as potentially target-selecting cytotoxic agents [PDF]
, 1986 The present work is a study of the structure–activity relationships and mode of action of oestrogens substituted with alkylating functions. These compounds are cytotoxic agents potentially selective for oestrogen-responsive tumours, since the oestrogen ...
Peter M. Lockey (7166366)
core +7 more sources
Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents [PDF]
Antioxidants, 2022 Luigi Tarani +2 more
exaly +2 more sources
MPTAC links alkylation damage signaling to sterol biosynthesis
Redox Biology, 2022 Overproduction of reactive oxygen species (ROS) drives inflammation and mutagenesis. However, the role of the DNA damage response in immune responses remains largely unknown.
Tamaki Suganuma, Jerry L. Workman
doaj +1 more source
Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
doaj +1 more source
Mutation signatures specific to DNA alkylating agents in yeast and cancers. [PDF]
Nucleic Acids Res, 2020 Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (SN1 and SN2) are still unclear ...
Saini N +8 more
europepmc +2 more sources
Cell Reports, 2015 Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang +10 more
doaj +1 more source
Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. [PDF]
PLoS Genetics, 2013 Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues.
Jennifer A Calvo +10 more
doaj +1 more source
Biosynthesis of DNA-Alkylating Antitumor Natural Products
Molecules, 2022 DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highly active ...
Qiu-Yue Nie +3 more
doaj +1 more source