Results 111 to 120 of about 110,461 (301)
The alkylation of imine anions formation of enamines
, 1970 The ambident anions derived from imines were alkylated using a variety of solvents and alkylating agents. Under reactive conditions enamines (N-alkylation) are formed as the main products instead of the usually obsd. homologous imines (C-alkylation). The
Heiszwolf, G.J., Kloosterziel, H.
core +1 more source
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe [PDF]
, 2005 The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I +6 more
core +1 more source
Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis
Advanced Science, EarlyView.Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He +12 more
wiley +1 more source
S-alkylation of soft scorpionates
, 2013 The alkylation reactions of soft scorpionates are reported. The hydrotris(S-alkyl-methimazolyl)borate dications (alkyl=methyl, allyl, benzyl), which were prepared by the reaction of TmMe anion and primary alkyl halides, have been isolated and ...
Reglinski, John +8 more
core +4 more sources
Detosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides
, 2019 An efficient strategy for N/O-(deutero)alkylation of indoles and phenols with alkoxides/alcohols as the alkylation reagents is described. The consecutive detosylation/alkylation transformations feature mild reaction conditions, high ipso-selectivity ...
Dayou Zhong (5674901) +7 more
core +1 more source
H‐Bonding‐Induced Repulsion Between Small Groups Toward a Highly Puckered Benzene
Advanced Science, EarlyView.A benzene derivative bearing methylamino and nitro substituents adopts a boat‐shaped ring conformation. Comparison with four related compounds supports a role for intramolecular hydrogen bonding in constraining substituent orientations and promoting local steric crowding associated with ring puckering.
Chaofeng Zhao +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
Asymmetric Alkylation of β-Ketoesters
, 2016 Asymmetric Alkylation of β ...
Ellen M. Grenzer (3001662) +2 more
core +1 more source
Advanced Science, EarlyView.MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin +9 more
wiley +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources