Results 91 to 100 of about 110,461 (301)

Synthesis and Cytotoxicity Evaluation of 13-<em>n</em>-Alkyl Berberine and Palmatine Analogues as Anticancer Agents

Molecules, 2012
By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-<em>n</em>-hexyl/13-<em>n</em>-octyl berberine and palmatine chloride analogues <strong>4a</strong>–<strong>d </
Lei Zhang, Jingjing Li, Fei Ma, Shining Yao, Naisan Li, Jing Wang, Yongbin Wang, Xiuzhen Wang, Qizheng Yao   +8 more
doaj   +1 more source

Broslash;nsted Acid Catalyzed α-Alkylation of Aldehydes with Diaryl Methyl Alcohols

, 2011
Broslash;nsted Acid Catalyzed α-Alkylation of Aldehydes with Diaryl Methyl ...
JunminZhang, 李国辉, 孙慧, ChongXing, YongguiRobinChi   +4 more
core  

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as Reductant

, 2011
An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as ...
曹亮亮, 江国防, 王躲生, 周永贵   +3 more
core  

Alkylation of isobutane with light olefins catalyzed by zeolite beta [PDF]

, 2000
Alkylation of isobutane with ethene and propene was studied over an H-BEA catalyst in a well-stirred reactor. Under similar conditions of space velocity and paraffin-to-olefin feed ratio, lower initial olefin conversions were observed with ethene or ...
Feller, A.P., Seshan, Kulathuiyer, Andreas Feller, Gautam S Nivarthy, Nivarthy, G.S., Johannes A Lercher, Kulathuiyer Seshan, Lercher, J.A.   +7 more
core   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Pd(II)–NHC (NHC = N‐Heterocyclic Carbene)‐Catalyzed Alkylation of Primary Amides by Site‐Selective N─C(O) Activation

Advanced Science
Although over the past decade, there have been tremendous advances in amide bond cross‐coupling, one of the major remaining challenges is selective alkylation of ubiquitous primary amides.
Peng Lei, Yuge Hu, Deshuang Zhang, Jiuhui Ye, Yanqing Gao, Juntao Feng, Zhiqing Ma, Xili Liu, Michal Szostak   +8 more
doaj   +1 more source

Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms

Scientia Pharmaceutica, 2018
Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in ...
Igor V. Ukrainets, Anna A. Burian, Vyacheslav N. Baumer, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Igor A. Tugaibei, Natali I. Voloshchuk, Pavlo S. Bondarenko   +7 more
doaj   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates

Scientia Pharmaceutica, 2017
According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics.
Liliana Azotla-Cruz, Irina V. Lijanova, Igor V. Ukrainets, Natalya V. Likhanova, Octavio Olivares-Xometl, Natalya L. Bereznyakova   +5 more
doaj   +1 more source