Results 91 to 100 of about 64,700 (251)

Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide Modification

Angewandte Chemie, EarlyView.
While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond, Esteban Suárez‐Picado, Lena von Sydow, Hanna Bruss, Laurent Knerr, Magnus Johansson, Anaïs Noisier, Lara R. Malins   +7 more
wiley   +2 more sources

Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles

Beilstein Journal of Organic Chemistry, 2013
Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, α-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted ...
Adam Trawczyński, Robert Bujok, Zbigniew Wróbel, Krzysztof Wojciechowski   +3 more
doaj   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Crosslinking of Linear Polyimines Into Aminal‐Linked Porous Organic Polymers for C2 Hydrocarbon/Methane Separation

Angewandte Chemie, EarlyView.
Crosslinking of linear polyimines with aromatic diamines via nucleophilic addition converts nonporous polyimine precursors into aminal‐linked porous networks, offering a new strategy for synthesizing porous organic polymers. The resulting materials exhibit high C2 hydrocarbon adsorption capacity, excellent selectivity over CH4, and durable cyclic ...
Xuejie Li, Yayu Yan, Qiaohong Li, Michelle Åhlén, Chao Xu   +4 more
wiley   +2 more sources

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, EarlyView.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Direct trifluoroethylation of carbonyl sulfoxonium ylides using hypervalent iodine compounds

Beilstein Journal of Organic Chemistry
A novel study on the hypervalent iodine-mediated polyfluoroalkylation of sulfoxonium ylides was developed. Sulfoxonium ylides, known for their versatility and stability, are promising substrates for numerous transformations in synthetic chemistry.
Radell Echemendía, Carlee A. Montgomery, Fabio Cuzzucoli, Antonio C. B. Burtoloso, Graham K. Murphy   +4 more
doaj   +1 more source

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes

Angewandte Chemie, EarlyView.
Biological C–H methylation proceeds through radical pathways mediated by one‐electron redox cofactors, yet no synthetic model has reproduced this reactivity. Here, we report the first isolable Cu(II/III)–methyl complexes that mediate C–H methylation through hydrogen atom transfer and methyl radical rebound.
Emily N. Doss, Curtis E. Moore, Shiyu Zhang   +2 more
wiley   +2 more sources

Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures

Angewandte Chemie, EarlyView.
Our synthetic endeavor toward the total synthesis of the reported unprecedented tricyclic skeleton of the sesquiterpene pestalustaine A allowed us to perform divergent cyclizations of a bicyclo[4.4.1]undec‐3‐ene into complex tricyclic architectures and to revise the structure of the natural product.
Wei Cao, Alicia Ross, Jean‐Pierre Baltaze, Régis Guillot, Menglin Xu, Rongzhen Qin, Bingcheng Yang, Isabel Wong, Katayoon Formul, Cyrille Kouklovsky, Dean J. Tantillo, Vincent Gandon, Guillaume Vincent   +12 more
wiley   +2 more sources

Photochemical Ring Opening of Cyclopropyl Silyl Ethers Enables β–β Coupling, Radical‐Polar Crossover and Annulation

Angewandte Chemie, EarlyView.
A photochemical platform enables β–β coupling of cyclopropyl silyl ethers with electron‐deficient alkenes. The resulting adducts serve as entry points into annulative and radical–polar crossover pathways, providing rapid access to fused, bridged, and spirocyclic architectures, including late‐stage scaffold diversification to diterpene‐like carbocyclic ...
Jacop Rydén, Eilidh Young, Wilma Olsson, Eskil Flodén, Mattias Tan, Sebastian Clementson   +5 more
wiley   +2 more sources