Results 71 to 80 of about 166,984 (347)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Selective C(sp3)–H Arylation/Alkylation of Alkanes Enabled by Paired Electrocatalysis

, 2023
We report a combination of electrocatalysis and photoredox catalysis to perform selective C(sp3)–H arylation/alkylation of alkanes for the first time, in which a binary catalytic system based on earth-abundant iron and nickel is applied.
Rui, Sun, qingquan, lu, Siqi, Xiang, Long, Zou   +3 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Technological Features of Producing High-Index Oils in the Alkylation Process

Eurasian Chemico-Technological Journal
This article presents the results of studies on key technological parameters-namely temperature and the use of modified ZSM-5 catalysts with Zr and Fe-in the alkylation process aimed at producing high-viscosity-index oils.
G.A. Huseynova, G.A. Gasimova, N.M. Aliyeva, S.N. Osmanova   +3 more
doaj   +1 more source

Alkylating Agents Stronger than Alkyl Triflates [PDF]

Journal of the American Chemical Society, 2004
A new class of potent electrophilic "R(+)" alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB(11)Me(5)X(6)) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions with conventional alkylating agents such as alkyl triflates, using the high oxophilicity of silylium ...
Kato, Tsuyoshi, Stoyanov, Evgenii, Geier, Jens, Grützmacher, Hansjörg, Reed, Christopher A   +4 more
openaire   +4 more sources

C–H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C–H Bond

Journal of the American Chemical Society, 2019
The direct, site-selective alkylation of unactivated C(sp3)–H bonds in organic substrates is a long-standing goal in synthetic chemistry. General approaches to the activation of strong C–H bonds include radical-mediated processes involving highly ...
C. Morton, Qilei Zhu, H. Ripberger, L. Troian‐Gautier, Z. S. Toa, R. Knowles, E. Alexanian   +6 more
semanticscholar   +1 more source

Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent

, 2004
Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee.
Rossington, SB, Hussain, N, Wilkinson, JA, Leonard, J   +3 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Catalytic Asymmetric Reductive Alkylation of Enamines to Chiral Aliphatic Amines

, 2020
Herein, we report a mild and general nickel-catalysed asymmetric reductive alkylation to effectively convert enamines—a class of important yet underexploited feedstock chemicals—into drug-like α-branched chiral amines and derivatives.
Jia-Wang, Wang, Wan, Nie, Yan, Li, Yi-Fan, Zhao, Xi, Lu, Zhe, Chang, Zi-An, Yu, Yao, Fu   +7 more
core   +1 more source

Asymmetric C-Alkylation of Nitroalkanes via Enzymatic Photoredox Catalysis

, 2022
Tertiary nitroalkanes and the corresponding α-tertiary amines represent important motifs in bioactive molecules and natural prod-ucts. The C-alkylation of secondary nitroalkanes with electrophiles is a straightforward strategy for constructing tertiary ...
Jose, Carceller, Tianzhang, Qiao, Todd, Hyster, Samantha, MacMillan, Haigen, Fu   +4 more
core   +1 more source