Results 71 to 80 of about 107,279 (237)

Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones [PDF]

, 2013
2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl ...
Geden, Joanna V., Beasley, Benjamin, Clarkson, Guy J., Shipman, Michael   +3 more
core   +1 more source

Catalytic Friedel–Crafts Reactions of Unactivated Secondary Alcohols: Site-Selective ortho-Alkylation of Phenols [PDF]

, 2023
A combination of catalytic ZnCl2 and catalytic CSA enables the first site-selective Friedel–Crafts alkylation of phenolic derivatives with unactivated secondary alcohols.
Kevin, Kou, Charlene, Fan, Aaron, Pan, Lorraine, Rangel, Viviene, Nguyen   +4 more
core   +2 more sources

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Alkylation-Induced O-Atom Rearrangement in Nickel S-Oxygenates

, 2016
Reactions of organic halides MeI and Br(CH2)3Br with square planar nickel complexes of tetradentate N2SS‘ or N2S‘2 ligands (S‘ = RS(O)) have been explored for their potential to direct alkylation of metallosulfoxide sulfur and yield metal-bound organic ...
Rizalia M. Buonomo (2971323), Joseph H. Reibenspies (1407388), Marcetta Y. Darensbourg (1431775), John A. Bellefeuille (2978739), Craig A. Grapperhaus (1666657)   +4 more
core   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Synthesis, Structure, and Reactivity of Ruthenium and Osmium Nitrido Complexes with 1,2-Benzenedithiolate Ligands:  N- versus S-Alkylation

, 2016
The reactivity of the nitrido complexes (NnBu4)[Ru(N)(S2C6H4)2] (1) and (NnBu4)[Os(N)(S2C6H4)2] (2) (C6H4(SH)2 = 1,2-benzenedithiol) toward electrophiles, R+ (R = Me, Et, Ph3C), is described.
Dieter Sellmann (2539633), Frank W. Heinemann (1366557), Wolfgang Donaubauer (2973804), Michael W. Wemple (2972241)   +3 more
core   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Hydrodynamic modeling of an industrial reactor for sulfuric acid alkylation of isobutane with olefins

Известия Томского политехнического университета: Инжиниринг георесурсов
Relevance. The need to intensify existing industrial installations for the production of environmentally friendly high-octane alkylbenzene. Dispersion of hydrocarbon and sulfuric acid in the synthesis reactor determines the quality of the resulting ...
Uliana N. Kopycheva, Vyacheslav A. Chuzlov   +1 more
doaj   +1 more source

Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj   +1 more source