Results 51 to 60 of about 110,461 (301)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Ruthenium Complexes Bearing α‑Diimine Ligands and Their Catalytic Applications in N‑Alkylation of Amines, α‑Alkylation of Ketones, and β-Alkylation of Secondary Alcohols [PDF]

, 2022
New Ru(II) complexes encompassing α-diimine ligands were synthesized by reacting ruthenium precursors with α-diimine hydrazones. The new ligands and Ru(II) complexes were analyzed by analytical and various spectroscopic methods.
Roberta Bertani (831231), Sgarbossa, Paolo, Gayathri, Sekar, Roberta Bertani, Viswanathamurthi, Periasamy, Paolo Sgarbossa (831232), Sekar Gayathri (13753826), Periasamy Viswanathamurthi (644688), Sekar Gayathri, Paolo Sgarbossa, Bertani, Roberta, Periasamy Viswanathamurthi   +11 more
core   +1 more source

Methanesulfonic Acid as a Dual‐Role Reagent for Porous Polymer Network Design

Advanced Materials, EarlyView.
The design of porous polymer networks (PPNs) using methanesulfonic acid (MSA) as a dual‐role reagent facilitates the synthesis of robust PPNs for specific applications. It also makes the scale‐up process techno‐economically feasible because MSA functions simultaneously as both a solvent and a catalyst for the reaction.
Kelechi Festus, Arnab Ghosh, Ankit Mondal, Theresa Ariri, Suman Mandal, Ahana Sarkar, Urme Podder, Qingsheng Wang, Hong‐Cai Zhou   +8 more
wiley   +1 more source

Enable biomass-derived alcohols mediated alkylation and transfer hydrogenation

Nature Communications
A single-atom catalyst with generally regarded inert Zn–N4 motifs derived from ZIF-8 is unexpectedly efficient for the activation of alcohols, enabling alcohol-mediated alkylation and transfer hydrogenation. C-alkylation of nitriles, ketones, alcohols, N-
Xixi Liu, Liang Huang, Yuandie Ma, Guoqiang She, Peng Zhou, Liangfang Zhu, Zehui Zhang   +6 more
doaj   +1 more source

Experimental validation of computational fluid dynamic codes (CFD) for liquid-solid risers in clean alkylation processes [PDF]

Hemijska Industrija, 2002
This manuscript, based on the presentation given by one of the authors (M.P. Dudukovic) at the Technological and Engineering Forum in Pančevo, May 21 2002, summarizes the use of the computer automated radioactive particle tracking (CARPT) and gamma ...
Duduković Milorad P., Al-Dahhan Muthanna H., Roy Shantanu, Kemoun Abdenour   +3 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

Molecules, 2020
A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno ...
Emad M. Gad, Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, Ahmed T. A. Boraei   +5 more
doaj   +1 more source

Modulation of Charge Transfer by N-Alkylation to Control Photoluminescence Energy and Quantum Yield [PDF]

, 2020
Charge transfer in organic fluorophores is a fundamental photophysical process that can be either beneficial, e.g., facilitating thermally activated delayed fluorescence, or detrimetnal, e.g., mediating emission quenching.
Andrew T., Turley, Andrew P., Monkman, Antonio, Prlj, Paul R., McGonigal, Andrew, Danos, Marc, Etherington, Basile F.E., Curchod   +6 more
core   +2 more sources

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Technological Features of Producing High-Index Oils in the Alkylation Process

Eurasian Chemico-Technological Journal
This article presents the results of studies on key technological parameters-namely temperature and the use of modified ZSM-5 catalysts with Zr and Fe-in the alkylation process aimed at producing high-viscosity-index oils.
G.A. Huseynova, G.A. Gasimova, N.M. Aliyeva, S.N. Osmanova   +3 more
doaj   +1 more source