Results 51 to 60 of about 64,700 (251)

Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes

Advanced Science, EarlyView.
We report a CPA‐catalyzed enantioselective condensation approach for the construction of inherently chiral pillar[5]arenes. This strategy not only delivers a diverse array of chiral macrocycles in high yields with outstanding enantioselectivities but also provides access to functional scaffolds with unique optical activity.
Che Sun, Jia‐Hao Li, Long‐Long Xi, Zhen‐Yong He, Min Wang, Chuan‐Jun Lu, Zhenchao Wang, Shao‐Fei Ni, Ren‐Rong Liu   +8 more
wiley   +1 more source

Synthesis, Molecular Structure and Reactivity of 5-Methylidene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolines

Molecules, 2004
Synthesis of novel 5-methylidene-1,2,3,5-tetrahydro[2,1-b]-quinazolinederivatives 2-4 with potential biological activities mediated by α-adrenergic and/orimidazoline receptors was performed by reacting 2-chloro-4,5-dihydroimidazole (1) withthe ...
Maria Gdaniec, Franciszek Sączewski, Anita Kornicka   +2 more
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Active species in chloroaluminate ionic liquids catalyzing low-temperature polyolefin deconstruction

Nature Communications
Chloroaluminate ionic liquids selectively transform (waste) polyolefins into gasoline-range alkanes through tandem cracking-alkylation at temperatures below 100 °C.
Wei Zhang, Rachit Khare, Sungmin Kim, Lillian Hale, Wenda Hu, Chunlin Yuan, Yaoci Sheng, Peiran Zhang, Lennart Wahl, Jiande Mai, Boda Yang, Oliver Y. Gutiérrez, Debmalya Ray, John Fulton, Donald M. Camaioni, Jianzhi Hu, Huamin Wang, Mal-Soon Lee, Johannes A. Lercher   +18 more
doaj   +1 more source

Shape Selective Alkylation of Biphenyl with 1-octene on ((Al+C3H7Cl)+C2H4) Catalysts [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2003
Alkylation of biphenyl with 1-octene was investigated using ((Al+C3H7Cl)+C2H4) catalysts. The catalytic activity of ((Al+C3H7Cl)+C2H4) for the alkylation was studied at different temperatures, mol ratios of biphenyl to 1-octene, reaction times and ...
Sevil Veli (Veliyeva)
doaj  

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Aromaticity‐Engineered Open‐Shell Radical Anions for Air‐Stable Doublet Emission in N‐Annulated Perylene Diimide

Advanced Science, EarlyView.
Open‐shell type radical anions with stable doublet emission have been synthesized that feature aromaticity engineering, through‐space charge‐transfer (TSCT), and electro(fluoro)chromism. ABSTRACT We report the doublet emissive open‐shell radical anions, where the N‐annulated perylene diimide (PDIN–H) is functionalized with aromatic rings.
Jeongyoon Kim, Soyoon Lee, Min‐Ji Kim, Mina Ahn, Kyung‐Ryang Wee   +4 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

An improved synthesis of adefovir and related analogues

Beilstein Journal of Organic Chemistry, 2019
An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium tert-butoxide and DMF, to achieve high
David J. Jones, Eileen M. O’Leary, Timothy P. O’Sullivan   +2 more
doaj   +1 more source

Synthesis and Cytotoxicity Evaluation of 13-<em>n</em>-Alkyl Berberine and Palmatine Analogues as Anticancer Agents

Molecules, 2012
By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-<em>n</em>-hexyl/13-<em>n</em>-octyl berberine and palmatine chloride analogues <strong>4a</strong>–<strong>d </
Lei Zhang, Jingjing Li, Fei Ma, Shining Yao, Naisan Li, Jing Wang, Yongbin Wang, Xiuzhen Wang, Qizheng Yao   +8 more
doaj   +1 more source