Results 51 to 60 of about 166,984 (347)

Cu-catalyzed Asymmetric Alkylation for Chiral Unnatural α-Substituted α-Amino Acids of Phallotoxins

, 2023
Asymmetric alkylation is one of the most important methods for synthesizing chiral unnatural α-substituted α-amino acids. Herein, We reported an asymmetric alkylation of tert-butyl glycinate Schiff base catalyzed by copper/(4S,2R)-tBu-Phosferrox ...
Yang, Wang, Xinlong, Yan, Jiashan, Li, Zongwei, Li, Lin, Fan, Guodu, Liu, Le, Pan   +6 more
core   +1 more source

Experimental validation of computational fluid dynamic codes (CFD) for liquid-solid risers in clean alkylation processes [PDF]

Hemijska Industrija, 2002
This manuscript, based on the presentation given by one of the authors (M.P. Dudukovic) at the Technological and Engineering Forum in Pančevo, May 21 2002, summarizes the use of the computer automated radioactive particle tracking (CARPT) and gamma ...
Duduković Milorad P., Al-Dahhan Muthanna H., Roy Shantanu, Kemoun Abdenour   +3 more
doaj   +1 more source

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes.

Journal of the American Chemical Society, 2019
We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones.
T. Ishii, Yuki Kakeno, K. Nagao, H. Ohmiya   +3 more
semanticscholar   +1 more source

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

Molecules, 2020
A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno ...
Emad M. Gad, Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, Ahmed T. A. Boraei   +5 more
doaj   +1 more source

Oxidation and alkylation stresses activate ribosome-quality control

Nature Communications, 2019
Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties within RNA. It is, however, unclear whether organisms have evolved general mechanism(s) to deal with this damage.
Liewei L. Yan, Carrie L. Simms, Fionn McLoughlin, R. Vierstra, Hani S. Zaher   +4 more
semanticscholar   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1

Redox Biology, 2013
Cigarette smoking remains a major health concern worldwide, and many of the adverse effects of cigarette smoke (CS) can be attributed to its abundant electrophilic aldehydes, such as acrolein (2-propenal).
Matthew J. Randall, Page C. Spiess, Milena Hristova, Robert J. Hondal, Albert van der Vliet   +4 more
doaj   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

Journal of Pharmaceutical Analysis
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by Kelch-like ECH-associated protein 1 (Keap1) alkylation plays a central role in anti-inflammatory therapy.
Ke-Gang Linghu, Tian Zhang, Guang-Tao Zhang, Peng Lv, Wen-Jun Zhang, Guan-Ding Zhao, Shi-Hang Xiong, Qiu-Shuo Ma, Ming-Ming Zhao, Meiwan Chen, Yuan-Jia Hu, Chang-Sheng Zhang, Hua Yu   +12 more
doaj   +1 more source

Modeling of Benzene with Ethylene Alkylation

MATEC Web of Conferences, 2016
The paper considers the benzene alkylation with ethylene model development with the use of zeolite catalyst. A list of reactions occurring in the alkylation reactor was made and the thermodynamic possibility of determination of these reactions by the ...
Khlebnikova Elena, Dolganova Irena, Ivashkina Elena, Koshkin Stanislav   +3 more
doaj   +1 more source