Results 41 to 50 of about 107,279 (237)

Direct C2–H alkylation of indoles driven by the photochemical activity of halogen-bonded complexes

Beilstein Journal of Organic Chemistry, 2023
A light-driven metal-free protocol for the synthesis of sulfone-containing indoles under mild conditions is reported. Specifically, the process is driven by the photochemical activity of halogen-bonded complexes formed upon complexation of a sacrificial ...
Martina Mamone, Giuseppe Gentile, Jacopo Dosso, Maurizio Prato, Giacomo Filippini   +4 more
doaj   +1 more source

Modeling of Benzene with Ethylene Alkylation

MATEC Web of Conferences, 2016
The paper considers the benzene alkylation with ethylene model development with the use of zeolite catalyst. A list of reactions occurring in the alkylation reactor was made and the thermodynamic possibility of determination of these reactions by the ...
Khlebnikova Elena, Dolganova Irena, Ivashkina Elena, Koshkin Stanislav   +3 more
doaj   +1 more source

Asymmetric alkylation of diarylmethane derivatives

, 2006
Deprotonation–alkylation of prochiral diarylmethane substrates using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee.
Rossington, SB, Ducki, S, Hussain, N, Wilkinson, JA, Leonard, J   +4 more
core   +1 more source

First and Second Sphere Interactions Accelerate Non-Native N-Alkylation Catalysis by the Thermostable, Methanol-Tolerant B12-Dependent Enzyme MtaC [PDF]

, 2022
During efforts to explore the range of reactions catalyzed by the previously-engineered B12-dependent enzyme CarH*, we found that this enzyme catalyzes N-alkylation of aniline using ethyl diazoacetate but that B12 itself provides only trace conversion ...
Jianbin, Li, Xinhang, Yang, Amardeep, Kumar, Jared, Lewis   +3 more
core   +2 more sources

Direct C(sp2)–H alkylation of unactivated arenes enabled by photoinduced Pd catalysis

Nature Communications, 2020
Direct catalytic C(sp2)–H alkylation of unactivated arenes with alkyl halides remains elusive despite the progress in C-H functionalization. Here, the authors report the catalytic C(sp2)–H alkylation of unactivated arenes with alkyl bromides via visible ...
Daeun Kim, Geun Seok Lee, Dongwook Kim, Soon Hyeok Hong   +3 more
doaj   +1 more source

Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1

Redox Biology, 2013
Cigarette smoking remains a major health concern worldwide, and many of the adverse effects of cigarette smoke (CS) can be attributed to its abundant electrophilic aldehydes, such as acrolein (2-propenal).
Matthew J. Randall, Page C. Spiess, Milena Hristova, Robert J. Hondal, Albert van der Vliet   +4 more
doaj   +1 more source

CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence [PDF]

, 2018
Enantioenriched molecules bearing indole-substituted stereocenters form a class of privileged compounds in biological, medicinal, and organic chemistry.
Jinhoon, Jeong, Yuxuan, Ye, Stephen L., Buchwald, Seoung-Tae, Kim, Mu-Hyun, Baik   +4 more
core   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

Journal of Pharmaceutical Analysis
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by Kelch-like ECH-associated protein 1 (Keap1) alkylation plays a central role in anti-inflammatory therapy.
Ke-Gang Linghu, Tian Zhang, Guang-Tao Zhang, Peng Lv, Wen-Jun Zhang, Guan-Ding Zhao, Shi-Hang Xiong, Qiu-Shuo Ma, Ming-Ming Zhao, Meiwan Chen, Yuan-Jia Hu, Chang-Sheng Zhang, Hua Yu   +12 more
doaj   +1 more source