Results 121 to 130 of about 110,461 (301)
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source
Thermodynamic analysis of benzene alkylation with propylene
Известия Томского политехнического университета: Инжиниринг георесурсов, 2019 Relevance of the research is caused by broad application of alkylation in industry and the necessity to develop a mathematical model adequate on the predicting ability and suitable for solving the technological problems in producing cumene with aluminum ...
Alena Chudinova +3 more
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Copper-catalyzed arylation of alkyl halides with arylaluminum reagents
Beilstein Journal of Organic Chemistry, 2015 We report a Cu-catalyzed coupling between triarylaluminum reagents and alkyl halides to form arylalkanes. The reaction proceeds in the presence of N,N,N’,N’-tetramethyl-o-phenylenediamine (NN-1) as a ligand in combination with CuI as a catalyst.
Bijay Shrestha, Ramesh Giri
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Nodal T‐follicular helper cell lymphoma (nTFHL), most commonly of angioimmunoblastic type, exhibits heterogeneous clinical outcomes that are not fully explained by current clinical and biological variables. While genetic alterations have been extensively investigated, its proteomic landscape remains largely unexplored.
David Beauvais +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
, 2013 Cu(OTf)2-Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction of Indoles with Arylidene Malonates Using Bis(sulfonamide)-Diamine ...
吴凡, 王东平, 万伯顺, 吴静
core
An alkylation process of naphthol
, 2023 The present invention is related to an improved process for alkylation of naphthol. Particularly, the present invention is related to a process for alkylation of 1-naphthol to 2-methyl-1 ...
Fabrizio Cavani +4 more
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Angewandte Chemie, EarlyView.Mixed MtaABC/MtgABC methyltransferase systems were developed for non‐native thiol and aniline methylation using the unactivated methyl donors methanol and glycine betaine. The platform enabled site‐selective and enantioselective methylation with turnover number up to 6000, representing the first enantioselective non‐native catalysis by cobamide ...
Amardeep Kumar +3 more
wiley +1 more source
An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation
Angewandte Chemie, EarlyView.YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue +2 more
wiley +2 more sources
Orbital: The Electronic Journal of Chemistry, 2010 Selectivity of alkylation at the N1 position in pyrimidines (thymine and uracil) was achieved by the application of N3-benzoyl thymine and N3-benzoyl uracil as substrates, where the N3 atom was temporarily protected, exposing the N1 atom as the ...
Fábio D. P. Soares +3 more
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