Results 231 to 240 of about 110,461 (301)

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

Chemo-, Diastereo-, and Enantioselective Radical Cyclization of Enals to Access Cyclopentanols Bearing an α-Quaternary Center. [PDF]

Angew Chem Int Ed Engl
Wang C, Long L, Li H, Chen H, Dong Z, Zeng X.   +5 more
europepmc   +1 more source

Copper-catalyzed and Y(OTf)₃-promoted deoxyaminative alkylation of imidazo[1,2-<i>a</i>] pyridines with benzyl alcohols and amines. [PDF]

RSC Adv
Hu R, Gao J, Chen T, Zheng L, Guo J, Cao Y, Luo R, Liu Z.   +7 more
europepmc   +1 more source

Decarboxylative alkylation of alkenes. [PDF]

Nature
Roy TK, Tamborini FM, Petzold R, Fu J, Tang Y, Ritter T.   +5 more
europepmc   +1 more source

Reaction of Hydrogermanes ArGeH₃ with Organolithium Reagents RLi: Unexpected Transfer of Organic Groups Instead of Lithiation. [PDF]

Inorg Chem
Schmid P, Leuprecht P, Schaffler-Glössl AM, Lee VY, Uhlig F.   +4 more
europepmc   +1 more source

Implementing modular design principles for molecular homogeneous catalyst discovery.

Catal Sci Technol
Millward F, Grills BS, Dauncey EM, Clark KF, Bhawal BN.   +4 more
europepmc   +1 more source

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Analysis of alkyl phosphates by extractive alkylation

Bulletin of Environmental Contamination and Toxicology, 1981
The development of suitable methods for analysis of the alkyl phosphate metabolites of organophosphorus pesticides in urine has been a rather d i f f i cu l t and persistent problem. Currently available methodology (BRADWAY et al. 1977; LORES & BRADWAY 1977; SHAFIK et al. 1973) suffers from several shortcomings.
D E, Bradway, R, Moseman, R, May
openaire   +2 more sources