Results 181 to 190 of about 71,058 (285)

Radical docking-migration: a powerful strategy for difunctionalization of alkenes and alkynes. [PDF]

Chem Sci
Cao Z, Chen F, Zhu C.
europepmc   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Divergent Access to α,β-Unsaturated Thiolated and Selenolated Lactams via a Unified Palladium-Catalyzed Carbonylative Transformation. [PDF]

Org Lett
Yin Z, Sun S, Qin X, Li H, Zhu F, Wu XF.
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Methanol-Mediated Nickel-Catalyzed Chemo- and Enantioselective Three-Component Alkenylative Coupling of Aldimines and Alkynes with Alkenyl Boronic Acids. [PDF]

JACS Au
Li ZX, Tao SC, Wang GS, Liu Y, Guo X, Zheng YL.   +5 more
europepmc   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Rhodium-Catalyzed Reductive Carbonylative Cyclization of Aryl Alkynes with Hydrosilanes via C-H Activation to Access Silyl-Substituted Indanones. [PDF]

Org Lett
Zhu F, Zhou M, Wu XF.
europepmc   +1 more source

Advances in Catalysis Using N-Heterocyclic Carbene Platinum Complexes. [PDF]

Molecules
Smoczyńska A, Ostrowska S, Pietraszuk C.   +2 more
europepmc   +1 more source

Nickel-catalyzed decarbonylative addition of acylsilanes across alkynes <i>via</i> the cleavage of a carbon-silicon bond. [PDF]

Chem Sci
Morimoto Y, Ando T, Inagaki T, Fujimoto H, Tobisu M.   +4 more
europepmc   +1 more source

One-Electron Approach for Trans-Selective Alkyne Semi-Reduction via Cobalt Catalysis. [PDF]

J Am Chem Soc
Mondal R, Galmidi L, Tzaguy A, Sason T, Feller M, Iron MA, Avram L, Neumann R, Gnaim S.   +8 more
europepmc   +1 more source