Results 81 to 90 of about 2,624,990 (309)

Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults [PDF]

, 2018
INTRODUCTION: Recent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse ...
Gathirua-Mwangi, Wambui Grace, Guo, Jianjun, Li, Ran, Li, Yufeng, McKenzie, Steve, Song, Yiqing, Xia, Jin, Zhang, Xi   +7 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project [PDF]

, 2013
Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe. We estimated the short-term effects of PM with aerodynamic diameter = 10 µm (PM10), = 2.5 µm
Agis Cherta, David, Alessandrini, Ester, Declercq, Christophe, Díaz, Julio, Forastiere, Francesco, Karanasiou, Angeliki, Katsouyanni, Klea, Kelessis, Apostolos G., Le Tertre, Alain, Ostro, Bart, Pandolfi, Paolo, Randi, Giorgia, Rodopoulou, Sophia, Samoli, Evangelia, Scarinzi, Cecilia, Stafoggia, Massimo, Study Group, MED-PARTICLES, Zauli-Sajani, Stefano   +17 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association

Scientific Reports
Identifying dependable prognostic indicators is essential for the efficient management of metabolic dysfunction-associated steatotic liver disease (MASLD).
Mengjie Zhao, Ning Sun, Yurong Cheng, Wantong Zhang, Jinjin Ji, Qiuyan Li, Fang Lu, Weiliang Weng   +7 more
doaj   +1 more source

Association of cooking fuel use with risk of cancer and all-cause mortality among Chinese elderly people: a prospective cohort study [PDF]

, 2023
Gang Tian, Yulan Ma, Yiran Cui, Wenyan Yang, Jingliang Shuai, Yan Yan   +5 more
openalex   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Retraction and republication—Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses [PDF]

, 2023
The Editors of The Lancet Diabetes Endocrinology
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The association between the BRI and all-cause and cardiovascular mortality in COPD patients

BMC Pulmonary Medicine
Objective Waist circumference (WC) has been linked to exacerbations in chronic obstructive pulmonary disease (COPD), but the relationship between WC, height, and the Body Roundness Index (BRI) with mortality in COPD patients remains unclear.
Riken Chen, Yuli Cai, Qinghua Chen, Zhaojun Chen, Huan Li, Yihuan Su, Wenxi Li, Yitian Yang, Xing Li, Xinyao Liu, Junfen Cheng, Lijuan Zeng, Huimin Chen, Baozhi Zhang   +13 more
doaj   +1 more source