Results 91 to 100 of about 4,043,885 (307)
Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF [PDF]
, 2015 M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions.Abadier, R., Abelson, M., Abhyankar, A., Abram, N., Achimastos, A., Agacdiken Agir, A., Agah, R., Agamasu, J., Aganauskiene, J., Ageno, W., Agnelli, G., Aguirre, A., Ahuad Guerrero, A., Aidietiene, S., Aiub, J., Akyea Djamson, A., Al Saghir, Y., Al Zoebi, A., Albina, G., Albirini, A., Alcocer Gamba, M., Alekseeva, N., Alessi, S., Alexeeva, O., Alfieri, A., Almaguer, E., Almquist, A., Altunkeser, B., Alvarado, O., Alvarez Garcia, P., Alvarez Lopez, H., Alvariqueta, A., Alzaghrini, G., Amaram, S., Amerena, J., Amosova, K., Amuchastegui, M., Anderson, C., Anderson, J., Andrews, R., Angelova, I., Antonios, N., Antonishen, M., Anusauskiene, J., Archibald, J., Arkhipov, M., Aron, G., Aroney, G., Arouni, A., Artis, A., Arzola, F., Ashchi, M., Ata, N., Avezum, A., Awan, N., Ayala Paredes, F., Bacon, J., Baek, S., Balaguer, J., Ballyzek, M., Balparda, C., Banerjee, S., Banker, D., Baranov, A., Baranova, E., Barbarash, O., Barbarich, V., Barber, A., Barreto Filho, J., Basart, D., Basri, H., Batalla, E., Bath, P., Batushkin, V., Bauknecht, C., Baumgartner, R., Bayat, J., Baños Velasco, A., Becker, R., Becker, Richard C., Bedwell, N., Behrens Humbold, S., Behrens Spandau, S., Belber, A., Belenky, D., Belgi, A., Bell, A., Beltran, R., Bengus, C., Bennett, J., Bennett, M., Benov, H., Bental, T., Bereczki, D., Berg Johansen, J., Berger, L., Bergman, S., Berk, M., Berkovich, O., Berkowitz, Scott D., Berlingieri, J., Bernan, A., Bernhardt, P., Bernstein, I., Berry, J., Bertholds, E., Bertolet, B., Bessoudo, R., Bester, F., Bhagwat, R., Bhamjee, H., Bhesania, T., Biedrzycka, M., Bilsker, M., Binetti, G., Bladin, C., Blitz, L., Blombery, P., Blomstrom, P., Bluguermann, J., Bodanese, L., Bode, C., Bojinca, M., Bokarev, I., Boldueva, S., Bolohan, F., Borelli, F., BORIANI, Giuseppe, Borromeo, S., Borts, D., Bosch, R., Boscher, D., Botero Lopez, R., Bouchal, P., Boulliat, J., Bowden, W., Boyarkin, M., Bozza, A., Brachmann, J., Braga, J., Brainin, M., Braun, E., Breithardt, Günter, Brenner, B., Broderick, G., Bronnum Schou, J., Brown, C., Brownscombe, L., Bruce, G., Bruguera Cortada, J., Bugrova, O., Bunster, L., Burger, A., Butnaru, A., Caime, G., Califf, Robert M., Calvi, V., Calvo Iglesias, F., Capo, J., Carlsater, J., Carolei, A., Carrier, S., Cartasegna, L., Caruso, A., Casabe, J., Castagnino, J., Cavero Gibanel, M., Ceyhan, C., Cha, J., Chahin, M., Challa, P., Chandna, H., Chandrasekaran, S., Chandrashekhar, Y., Chang, D., Chang, M., Chappel, C., Charme, G., Charng, M., Chastain, S., Chaturvedi, S., Chehayeb, R., Chekherdemian, S., Chen, C., Chen, J., Chen, K., Chen, Y., Cheng, Y., Chernov, S., Cheung, M., Chiang, F., Chilvers, M., Chiru, M., Chockalingam, K., Choi Siruckova, J., Choi, Y., Chojnowska, L., Chong, P., Choudhry, A., Chua, W., Chumakova, G., Chung, C., Chung, N., Cihalik, C., Cimbaro Canella, J., Cin, V., Cinteza, M., Cirrincione, V., Citron, B., Claus, G., Cleland, J., Cohen, Y., Coisne, D., Cojocaru, T., Collette, R., Collins, B., Coloma, R., Constance, C., Cooke, J., Corbelli, J., Corbett, C., Coronel, J., Cosmi, F., Costa, F., Coutu, B., Cox, S., Coyle, J., Crijns, H., Crimmins, D., Cross, D., Crowley, D., Csanyi, A., Cuadrado, J., Cucher, F., Cuneo, C., Cytryn, R., D'Angelo, A., D'Aurea Mora, R., Da Silva, A., Daboul, N., Daenschel, W., Dahlstrom, C., Dailydkiene, A., Dalby, A., Dale, H., Darius, H., Dawood, M., Dayan, M., De Caterina, R., de la Hera Galarza, J., De los Rios, M., De Ruiter, G., de Souza Neto, J., de Souza, W. Sebba Barroso, De Wolf, L., Debruyne, P., Del Campo, R., Del Pino, R., Demin, A., Dempfle, C., Deruyter, B., Desantis, M., Destrac, S., Di Biase, M., Dieckmann, H., Dietrich, D., Diker, E., Dimitrova, S., Dioszeghy, P., Doerr, M., Dohmann, H., Donahue, M., Donnan, G., Doyle, W., Drago Silva, J., Dragulescu, S., Dran, R., Drexel, H., Drzewiecki, A., Dunaj, M., Durairaj, R., Durfresne, M., Dvornikov, V., Dyadyk, O., Dykstra, G., Dzyak, G., Ebert, H., Ebo, G., Ebrahim, I., Eichinger Hasenauer, S., Eisenberg, S., El Ali, H., El Khadra, M., Eldar, M., Elias, M., Elias, N., Elle, S., Ellie, E., Elsen, J., Emlein, G., Ernesto Leaes, P., Escudero, A., Etemoglu, M., Ezekiel, D., Fadl, Y., Faiers, A., Fan, K., Fargher, T., Fattore, L., Faynyk, A., Felsen, S., Fernandes, V., Fierbinteanu, C., Figueiredo, E., Figueroa, H., First, B., Fishberg, R., Fisher, D., Fisher, R., Fitzpatrick, D., Flores, A., Fokin, A., Fontcuberta, J., Forster, T., Fortin, C., Foster, M., Fournier, P., Fox, D., Fox, Keith A. A., Frandsen, B., French, W., Friedlander, I., Fu, G., Fuentealba, V., Furlan, M., Furuseth, K., Gabelmann, M., Gabito, A., Gaciong, Z., Gadkari, M., Galinier, M., Gallegos, J., Galley, D., Galve Basilio, E., Ganam, R., Gandolfo, C., Ganim, R., Garbelini, B., Garces, E., Garcia Brasca, D., Garg, N., Gautam, P., Gelernt, M., Genth Zotz, S., Georgeson, S., Gerraty, R., Ghanekar, R., Ghorayeb, N., Gill, S., Gillis, G., Go, A., Go, A., Goethals, M., Goethals, P., Gogia, H., Goldberg, B., Goldman, H., Gomes, M., Gonzalez Juanatey, J., Gonzalez, M., Goszczynska, M., Gould, D., Gowdappa, B., Gozhenko, A., Gradek, G., Gratsiansky, N., Grigoniene, L., Grigorova, V., Grishyna, O., Grooterhorst, P., Groutars, R., Guelker, H., Guevara, C., Gulati, R., Guthrie, R., Gutman, N., Hacke, Werner, Haldis, T., Hall, C., Halperin, Jonathan L., Hamer, B., Hamroff, G., Hankey, Graeme J., Hart, H., Hasbani, E., Hasty, R., Heath, J., Heddle, W., Heffernan, M., Heidbuchel, H., Heilman, J., Heinc, P., Heitner, J., Held, J., Hellemans, S., Herbst, L., Hernandez, E., Hershson, A., Hertzeberger, D., Herzog, W., Hill, L., Ho, D., Hodson, R., Hoffman, A., Hohensee, H., Hoivik, H., Hominal, M., Hong, T., Hong, X., Hoogslag, P., Hotchkiss, D., Howard, V., Hrabar, A., Hsieh, I., Hsieh, Y., Hu, D., Huang, C., Huang, T., Huang, Y., Huber, K., Hudson, I., Hunt, B., Hunter, J., Hutchinson, B., Hyers, T., Idowu, O., Idrisova, E., Iglesias Alonso, L., Ionescu, D., Ip, J., Isea, J., Iuzkiv, I., Ivleva, A., Izmozherova, N., Jaber Houbani, A., Jaber, J., Jackson, D., Jackson, P., Jacobs, G., Jaffer, S., Jaffrani, N., Jagan, N., Jain, P., Jain, S., Jamnadas, P., Jandik, J., Jano, G., Janorkar, S., Janosi, A., Janota, T., Janousek, J., Janssen, M., Jaramillo, C., Jauch, W., Jaworska, K., Jeffery, P., Jensen, G., Jetty, P., Jin, S., Jo, S., Jones, A., Jones, M., Jones, R., Jure, H., Jäkälä, P., Kadel, C., Kadina, L., Kadr, H., Kaeaeb, S., Kafka, H., Kalo, E., Kalra, B., Kania, G., Karadede, A., Karczmarczyk, A., Karpenko, O., Karrasch, J., Karrasch, J., Karrasch, J., Kaste, M., Kates, M., Katz, A., Kavaliauskiene, R., Kavoliuniene, A., Kazimirko, V., Kazmierski, J., Kellnerova, I., Kelly, D., Kenton, D., Kerr Saraiva, J., Keshavamurthy, C., Ketova, G., Kevorkian, R., Khan, W., Khera, A., Khokhlov, A., Khomazyuk, T., Khozyainova, N., Khrustalev, O., Khurana, M., Kim, C., Kim, C., Kim, C., Kim, K., Kim, Y., Kingsley, J., Kinney, K., Kirby, A., Kis, E., Kiss, R., Kjaernli, T., Klarlund, K., Klein, S., Kneller, G., Koenig, A., Kohler, B., Koifman, B., Koliopoulos, N., Kolodziej, P., Komoly, S., Kondo, N., Kononenko, L., Kooy, J., Kopaczewski, J., Kopytsya, M., Koren, M., Kornacewicz Jach, Z., Kosa, I., Koshukova, G., Kostenko, V., Kouz, S., Koval, O., Kowal, J., Kozak, J., Kozan, O., Kraemer, A., Kragten, H., Krastev, A., Krittayaphong, R., Krueger, S., Krzciuk, M., Krzeminska Pakula, M., Kubica, J., Kuijper, A., Kumar, P., Kumbla, M., Kupchynska, O., Kutalek, S., Kuznetsov, V., Kyolean, M., Károly, T., Labroo, A., Lacnak, B., Lanas, F., Landel, R., Landmark, N., Landry, D., Lang, W., Langberg, J., Lange, R., Lasko, B., Lauer, M., Lavie, E., Lawall, H., Leader, R., Lebenthal, M., Leduc, J., Lee, C., Lee, F., Lee, H., Leicht, M., Leiva Pons, J., Levinson, L., Lewczuk, J., Lewis, B., Li, H., Li, Y., Li, Z., Liagkas, K., Liang, W., Liao, Y., Libis, R., Libov, I., Lichtenstein, T., Lieber, I., Lindholm, C., Ling, M., Linhart, A., Lip, G., Lippai, J., Lishnevska, V., Listorti, S., Liu, J., Liu, M., Liutkus, J., Lizogub, V., Llamas Esperon, G., Lloyd, E., Lobo Marquez, L., Loboz Grudzien, K., Logemann, T., Loktin, E., Lopes Prudente, M., Lopez, M., Lorga Filho, A., Lowy, A., Lu, G., Lu, Q., Lubelsky, B., Luengas, C., Lui, H., Lupkovics, G., Luquez, H., Lusov, V., Lustgarten, D., Luterman, M., Luton, R., Lynchard, G., Lytvynenko, N., Ma, C., Ma, J., Ma, P., Ma, S., Macarie, C., Macdonald, P., Machell, C., Mackinnon, I., Macleod, M., Macleod, M., Macwalter, R., Madhavan, A., Madhukar Naik, A., Magno, M., Mahaffey, Kenneth W., Maia, L., Makam, S., Malecha, J., Malik, A., Mallis, G., Manalo, C., Mandysova, E., Manenti, E., Mann, S., Manolis, A., Marabotti, C., Marchev, S., Marcinek, G., Marcinkeviciene, J., Marco Vera, P., Marmor, A., Martin, P., Martin, R., Martinez Rubio, A., Martynov, A., Masini, F., Maslov, S., Maung, T., Mawji, A., Mayer, N., Mazaev, V., Mazurov, V., Mazutavicius, R., Mazza, G., Mcelveen, A., Mcgarvey, J., Mcgrew, F., Mcinnes, G., Mclaughlin, P., Medina, F., Mego, D., Meholick, A., Melchior, T., Melucci, M., Mendoza, A., Meneses, G., Merino, J., Merino, R., Merlini, P., Meuser, M., Meyerrose, G., Meymandi, S., Micieli, G., Mihov, A., Mikhailov, S., Militaru, C., Miller, G., Mishchenko, T., Mkrtchian, V., Modares, F., Modi, M., Mody, F., Moebiuswinkler, S., Mohamed, Z., Moloney, J., Montana, O., Morales Alvarado, J., Moriarty, A., Morr, I., Moscoso, R., Mostel, E., Motta, M., Moura Jorge, J., Mucha, M., Muegge, A., Mukherjee, S., Muntaner, J., Murdoch, D., Mutrie, J., Myears, D., Nagy, A., Nahhas, A., Najarali, A., Namgung, J., Nanea, I., Nassiacos, D., Natase Melicovici, D., Navas, J., Negron, S., Nelson, W., Nessel, Christopher C., Netyazhenko, V., Newman, D., Newman, D., Newman, D., Ng, K., Niazi, I., Niazi, I., Nielsen, E., Nielsen, T., Nikolaides, K., Nilsson, C., Nord, P., Norkiene, S., Nortje, H., Novikova, T., Novozhenov, V., Nseir, W., Nunes Vaz, C., O'Mahony, M., O'Mahony, W., Ogorek, M., Olaz Preciado, F., Olivan Martinez, J., Olivares, C., Oliven, A., Omran, H., Ong, H., Oomman, A., Opolski, G., Orchard, R., Orfi, J., Osmancik, P., Ostadal, P., Osunkoya, A., Ouellet, A., Packham, D., Padour, F., Pai, P., Pan, D., Pandey, S., Panwar, R., Papastergiou, D., Papasteriadis, E., Pappas, J., Parati, G., Pardo, J., Parra Galvan, J., Parrott, C., Parsons, M., Patel, Manesh R., Patel, P., Pava, L., Peart, B., Pelayo, M., Pencheva, G., Pengo, V., Pereira Barretto, A., Perez, G., Pertseva, T., Pesant, Y., Petrascu, O., Petrauskiene, B., Phan, T., Piamsomboon, C., Piccini, Jonathan P., Pieper, Karen S., Piepiorka, M., Pieterse, M., Pilger, E., Pimentel Filho, P., Piotrowski, W., Piovaccari, G., Piovella, F., Pirchala, M., Pirvu, O., Pirwitz, M., Piskorz, D., Pitt, W., Piyayotai, D., Pluta, W., Podgorski, G., Pokorney, Sean D, Polasek, R., Ponte Negretti, C., Popa, V., Popeil, L., Popescu, M., Popik, G., Potthoff, S., Poveda, C., Precoma, D., Proskynitopoulos, N., Proulx, G., Provenier, F., Pruszczyk, P., Pugeda, J., Pugen, G., Purnell, I., Quintero, A., Rabelo, A., Radoi, M., Raev, D., Raffetto, J., Raffo, C., Rajakumar, A., Rajasekhar, V., Ramesh Babu, B., Ramshev, K., Rao, S., Rapallo, C., Raskina, T., Rasura, M., Raugaliene, R., Rebrov, A., Rebrov, B., Reddy, R., Reis, G., Reisler, H., Reiter, W., Renzi, M., Repin, A., Reshetko, O., Reyes, E., Riccitelli, M., Richards, M., Rifai, A., Rim, S., Rios, C., Risberg, K., Roan, P., Roberts Thomson, P., Robinson, A., Robinson, V., Rocha, J., Rockman, G., Rodriguez, I., Roehnisch, J., Roffe, C., Roine, R., Rolston, D., Roodt, A., Rosenhack, S., Rosman, A., Rossi dos Santos, F., Rossi, P., Roux, J., Roy, R., Rubin, M., Rudenko, L., Rudyk, I., Ruiter, J., Rupka, D., Russell, J., Ruszkowski, P., Ryamzina, I., Rynkiewicz, A., Rysava, D., Ryu, K., Saba, F., Sabe Affaki, G., Sackett, M., Saint Jacques, H., Saldana, A., Salvioni, A., Sam, C., Sanchez, A., Sanchez, D., Sandberg, J., Sandhu, J., Sandoval, R., Sanina, N., Sarnighausen, H., Sasseen, B., Scavee, C., Schellong, S., Schifferdecker, B., Schlau, A., Schnabel, A., Schneider, R., Schoen, N., Schroeder, T., Schwencke, C., Sciborski, R., Sedavnyh, I., Seidl, K., Seidner, M., Sekoranja, L., Senior, R., Seo, H., Sepulveda, P., Seredyuk, N., Serkova, V., Serra, J., Sessa, H., Seymour, Z., Sgammini, H., Shah, S., Shanes, J., Sharpe, C., Shen Ling, J., Shepherd, A., Sherenkov, A., Shershnyova, O., Shin, D., Shin, W., Shirwany, A., Shochat, M., Shoemaker, J., Shostak, N., Shoukfeh, M., Shrestha, D., Shubik, Y., Shulman, V., Shvarts, Y., Shved, M., Siebert, R., Silagy, S., Silva, R., Silver, E., Silverman, R., Sim, K., Simanekov, V., Simmons, J., Singer, Daniel E., Singh, R., Sinha, S., Sinkiewicz, W., Sipciu, D., Sipula, D., Sirenko, Y., Sirnes, P., Sitnikova, M., Skag, A., Skrebkov, V., Skripkauskiene, I., Skurtov, A., Smiley, N., Smith, D., Smith, T., Smolenskaya, O., Snipes, C., Snoddy, B., Snyder, H., Sobral Filho, D., Sokolova, L., Sommer, S., Sommers, R., Sonel, A., Song, J., Sonntag, F., Sotillo Marti, J., Sotolongo, R., Spacek, R., Speirs, S., Spitzer, S., St Maurice, F., Staab, M., Stamenova, P., Staniloae, C., Steel, K., Steg, G., Steingo, L., Stender, S., Stevens, Susanna R., Stewart, R., Stockdill, J., Stoikov, A., Stoltz, S., Storozhakov, G., Stransky, V., Strasser, R., Striekwold, H., Stryuk, R., Suarez, R., Sukonthasarn, A., Sulman, S., Sumpter, M., Sun, J., Sundaram, S., Sunsaneewitayakul, B., Suresh, D., Suresh, D., Sutherland, J., Svyshchenko, Y., Swissa, M., Syan, G., Sychov, O., Syed, H., Sykulski, R., Szulawski, I., Szwed, H., Taggeselle, J., Tahk, S., Tak, T., Tan, R., Tang, K., Tang, S., Tankhilevich, B., Tannenbaum, A., Tanomsup, S., Tatu Chitoiu, G., Tau, A., Taussig, A., Tebloev, K., Teitelbaum, E., Teixeira, M., Telfer, E., Tellier, G., Tenczer, J., Tendera, M., Tereschenko, S., Terrosu, P., Thacker, H., Theron, H., Thijssen, H., Thomas, G., Thompson, P., Thomsen, E., Tirador, L., Tissa Wijeratne, K., Topsakal, R., Torppedersen, C., Torrejon, H., Treasure, C., Treshkur, T., Trikas, A., Trusz Gluza, M., Tsai, C., Tsai, L., Tsanova, V., Tse, H., Tseluyko, V., Tudoran, M., Tudose, A., Turk, S., Tuxen, C., Ueng, K., Ungureanu, G., Urina, M., Ursol, G., Usedom, J., Uy, N., Vajda, M., Valikovics, A., van Boven, A., Van Der Heijden, R., van Gelder, I., Van Hessen, M., Van Langeveld, R., van Zyl, L., Vaniev, S., Varini, S., Vatutin, M., Vavougios, J., Vejar, M., Veldkamp, R., Veltkamp, R., Vergara, E., Vergara, G., Vertes, A., Vertes, G., Vexler, R., Vida, M., Vijay, N., Vijayaraghavan, K., Villafria, R., Villarreal Careaga, J., Villeda, E., Villegas, B., Vinereanu, D., Vintila, M., Virgen Carrilo, L., Vita, N., Vivanco, G., Vizel, S., Vo, A., Vogel, C., Vogel, D., Vojacek, J., Vojtisek, P., Volkov, V., Volkova, E., vom Dahl, J., Vora, K., Voronkov, L., Voyce, S., Vydianathan, P., Vykhovanyuk, I., Vysochanska, T., Waites, J., Wakham, M., Walia, J., Wallen, T., Walters, D., Wan Ahmad, W., Wang, H., Wang, J., Wang, Y., Warren, R., Watanabe, L., Weinstein, J., Weiss, A., Weissbrodt, M., Welka, S., White, J., Whittier, F., Wilkins, G., Williams, G., Williams, S., Wilson, V., Winkelmann, B., Wiseman, A., Withagen, A., Wong, F., Wong, L., Woodworth, G., Wu, S., Wu, Z., Xu, B., Xu, D., Yakhontova, P., Yakushin, S., Yan, X., Yang, J., Yang, K., Yang, T., Yarokhno, N., Yarows, S., Yavuzgil, O., Yeh, H., Yeh, H., Yellen, L., Yena, L., Yilmaz, O., Yin, W., Yin, Y., Yordanova, V., Yu, B., Yu, C., Yuan, Z., Yusof, Z., Zadionchenko, V., Zakhary, B., Zamolyi, K., Zateyshchikov, D., Zdravkov, N., Zebrack, J., Zelenka, J., Zeng, Z., Zhao, Y., Zheleznyy, V., Zhurba, S., Ziada, K., Zidkova, E., Ziegler, F., Zimerman, L., Zimetbaum, P., Zimlichman, R., Zimmermann, S., Zolty, R., Zrazhevsky, K., Zuber, M., Íñiguez, C. +1192 morecore +4 more sourcesSleep Duration and Risk of Fatal Coronary Heart Disease, Sudden Cardiac Death, Cancer Death, and All-Cause Mortality [PDF]
The American Journal of Medicine, 2018 Sleep duration has been shown to be associated with all-cause mortality; however, its relationship with cause-specific fatal events remains uncertain. We examined the relationship between sleep duration and risk of fatal coronary heart disease, sudden cardiac death, cancer-related death, and all-cause mortality.Sleep duration was self-reported at ...Khan, Hassan, Kella, Danesh, Kunutsor, Setor K., Savonen, Kai, Laukkanen, Jari +5 moreopenaire +5 more sourcesThe newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...Dylan Casey, Zeqian Gao, Joan Boyeswiley +1 more sourceAndersen-Tawil syndrome: report of 3 novel mutations and high risk of symptomatic cardiac involvement. [PDF]
, 2014 IntroductionAndersen-Tawil syndrome (ATS) is a potassium channelopathy affecting cardiac and skeletal muscle. Periodic paralysis is a presenting symptom in some patients, whereas, in others, symptomatic arrhythmias or prolongation of QT in ...Bieganowska, Katarzyna, Bienias, Piotr, Kaminska, Anna, Kostera-Pruszczyk, Anna, Lee, Hsien-Yang, Miszczak-Knecht, Maria, Ploski, Rafal, Potulska-Chromik, Anna, Pruszczyk, Piotr, Ptáček, Louis J, Quinn, Emily, Szczałuba, Krzysztof +11 morecore +2 more sourcesPICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath +7 morewiley +1 more sourceCell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten +5 morewiley +1 more sourceInhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski +7 morewiley +1 more sourceExpanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
BMC MedicineBackground Mosaic chromosomal alterations (mCAs) served as a novel indicator of genomic aging. We aimed to investigate the association of expanded mCAs (cell fraction ≥ 10%) with all-cause and cause-specific mortality, and to examine the joint effect of ...Mingyu Song, Zilun Shao, Yuting Han, Yuxuan Zhao, Jun Lv, Canqing Yu, Pei Pei, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Xiaoming Yang, Mengwei Wang, Junshi Chen, Zhengming Chen, Giulio Genovese, Chikashi Terao, Liming Li, Dianjianyi Sun, China Kadoorie Biobank Collaborative Group +20 moredoaj +1 more source
