Results 101 to 110 of about 4,043,885 (307)

Adiposity has differing associations with incident coronary heart disease and mortality in the Scottish population: cross-sectional surveys with follow-up [PDF]

, 2013
Objective: Investigation of the association of excess adiposity with three different outcomes: all-cause mortality, coronary heart disease (CHD) mortality and incident CHD.
A Adbullah, A H Leyland, A Romero-Corral, A Romero-Corral, A Romero-Corral, A Rosengren, A Shaw, AE Taylor, AJ Sogaard, B Schweikert, B Unal, B Wells, BJ Steinberg, C A Davies, C Bromley, D Wormser, DB Allison, DL McGee, DM Mann, DP Guh, E Pullen, E Strandhagen, EL Eisenstein, EW Gregg, G Whitlock, H Tunstall-Pedoe, HM Orpana, J Bigaard, J Rasbash, J Stevens, J W Hotchkiss, JA Simpson, Joel William Hotchkiss, JW Hotchkiss, K Barakat, KM Flegal, KM Flegal, KM Rexrode, KM Rexrode, L Gray, LL Yan, M Myerson, M Walker, MEJ Lean, MM Finucane, P Jousilahti, P McLoone, P Royston, PT Katzmarzyk, R Lawder, RH Eckel, RW Yeh, S Capewell, S Capewell, S Czernichow, S Yusuf, T Pischon, TE Strandberg, W Dong   +58 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stressful life-events exposure is associated with 17-year mortality, but it is health-related events that prove predictive [PDF]

, 2008
Objectives Despite the widely-held view that psychological stress is a major cause of poor health, few studies have examined the relationship between stressful life-events exposure and death.
Andersen, Anna C. Phillips, Brown, Cohen, Davison, Dohrenwend, Douglas Carroll, Ford, Geoff Der, Greenwood, Hemingway, Heslop, Hollis, Holmes, Macleod, Macleod, Maunsell, O'Brien, Rahe, Raphael, Registrar General, Rosengren, Rosengren, Ruberman   +23 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database. [PDF]

, 2013
Objective. Assess risk of cardiac events and mortality among users of olanzapine and other antipsychotics relative to nonusers. Methods. The General Practice Research Database was used to identify cohorts of antipsychotic users and nonusers with ...
Brunner, Elizabeth, Campbell, Giedra, Jones, Meghan E, Motsko, Stephen, Murray-Thomas, Tarita, Patel, Deven, Shatapathy, Chetan C, Van Staa, Tjeerd, van Staa, Tjeerd P   +8 more
core   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study

Annals of Noninvasive Electrocardiology
Objective To explore the influence of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation. Methods This retrospective observational cohort study included 196 patients, 75–102‐years‐old, with nonvalvular ...
Kan Zhang, Ying Sun, Jiancao Ding, Qing Ma, Dai Zhang, Wei Huang, Yunli Xing   +6 more
doaj   +1 more source

Cause-specific mortality as a sentinel indicator of current socioeconomic conditions in Italy [PDF]

, 2018
This study aims to assess whether simple, widely available demographic indexes, like mortality measures, may serve as sentinel indicators of the economic development and the social wellbeing in Italy.
Barbi, Elisabetta, Casacchia, Oliviero, Racioppi, Filomena   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Contemporary characteristics and outcomes in chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy [PDF]

, 2017
Background: Chagas’ disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas’ disease, with other ...
Claudio R. Gimpelewicz, Efraín A. Gómez, Felipe Martinez, Felix Ramires, Jean L. Rouleau, John J.V. McMurray, Karl Swedberg, Kenneth Dickstein, Lars Køber, Li Shen, Luis Eduardo Echeverría, Luiz Carlos Bodanese, Michael R. Zile, Milton Packer, null null, Pardeep S. Jhund, Scott D. Solomon, William T. Abraham   +17 more
core   +3 more sources