Results 81 to 90 of about 2,566,791 (345)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Endothelial Activation and Stress Index Predicts All‐Cause and Cardiovascular Mortality in Hypertensive Individuals: A Nationwide Study

The Journal of Clinical Hypertension
Emerging evidence links the Endothelial Activation and Stress Index (EASIX) and mortality risk in coronary artery disease, but its relevance in hypertensive patients remains unclear.
Gaiying Dong, Tingting Wu, Xiaofan Gu, Liangliang Wu   +3 more
doaj   +1 more source

Associations between diabetes and both cardiovascular disease and all-cause mortality are modified by grip strength: evidence from UK Biobank, a prospective population-based cohort study [PDF]

, 2017
OBJECTIVE Grip strength and diabetes are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to predispose to adverse health outcomes is unknown.
Anderson, Jana, Celis-Morales, Carlos A., Gill, Jason M.R., Gray, Stuart R., Hui, Li, Iliodromiti, Stamatina, Lyall, Donald M., Mackay, Daniel F., McLaren, James, Pell, Jill P., Petermann, Fanny, Sattar, Naveed, Welsh, Paul   +12 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Association of periodontitis with cardiovascular and all-cause mortality in hypertensive individuals: insights from a NHANES cohort study

BMC Oral Health
Background The objective of this research is to clarify the impact of periodontitis on overall and cardiovascular-related death rates among hypertensive individuals.
Jingru Li, Yajun Yao, Wenchao Yin, Shuai Feng, Pengcheng Yan, Leiyan Wang, Xiao Zhu, Kaiwen Zhang, Jingjing Tian, Zhaoyang Wang, Haitao Yuan   +10 more
doaj   +1 more source

Effect of exposure to natural environment on health inequalities: an observational population study [PDF]

, 2008
<b>Background:</b> Studies have shown that exposure to the natural environment, or so-called green space, has an independent effect on health and health-related behaviours.
Bibby, Brunner, Cohen, Davey-Smith, de Vries, Frank Popham, Giles-Corti, Grahn, Groenewegen, Hartig, Humpel, Jerrett, Kaczynski, Kahn, Kiecolt-Glaser, Krewski, Maas, Macintyre, Mackenbach, Mackenbach, Marmot, Marmot, Mitchell, Mitchell, Nowak, Popham, Pretty, Richard Mitchell, Roux, Saelens, Smith, Smith, Smith, Tardon, Ulrich, Ulrich, van den Berg, Warburton, Wilkinson, Wilkinson, Wilkinson, Williams, Woods, Yusuf   +43 more
core   +1 more source

Physical Performance and All-Cause Mortality in CKD [PDF]

Journal of the American Society of Nephrology, 2013
It is well documented that measures of exercise capacity and physical performance are impaired in people with ESRD who are undergoing maintenance dialysis therapy.[1][1]–[3][2] Several studies have also described impaired exercise capacity in CKD patients who have lesser degrees of reduced GFR,
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Urinary paranitrophenol levels and risk of cancer mortality: evidence from NHANES

BMC Cancer
Background Paranitrophenol, a metabolite of organophosphate insecticides, was associated with various adverse health outcomes. However, the association of Paranitrophenol with all-cause and cancer mortality in adults remains unclear. Methods A total of 3,
Wei Zhang, Guiyuan Liu, Wei Yuan, Qing Guo, Yan Chen, Gaohua Han   +5 more
doaj   +1 more source