Results 91 to 100 of about 106,674 (292)

All-Optical Modulation and Ultrafast Switching in MWIR with Sub-Wavelength Structured Silicon

Applied Sciences, 2019
We investigated and optimised the performance of the all-optical reflective modulation of the Mid-Wave Infrared (MWIR) signal by means of the optically-pumped sub-wavelength-structured optical membranes made of silicon.
Rihan Wu, Jack Collins, Dimitri Chekulaev, Andrey Kaplan   +3 more
doaj   +1 more source

60 GHz and 94 GHz antenna-coupled LiNbO_3 electrooptic modulators [PDF]

, 1993
Antenna-coupled LiBbO_3 electrooptic modulators can overcome the material dispersion which would otherwise prevent sensitive high-frequency operation. The authors previously demonstrated the concept with a phase modulator at X-band.
Bridges, William B., Schaffner, James H., Sheehy, Finbar T.   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Requirements on bit resolution in optical Ising machine implementations with analog spin variables

Communications Physics
Optical Ising machines have emerged as a promising dynamical hardware solver for computational hard optimization problems. These Ising machines typically require an optical modulator to represent the analog spin variables of these problems.
Toon Sevenants, Guy Van der Sande, Guy Verschaffelt   +2 more
doaj   +1 more source

Simulation and Fabrication Feasibility of Two-Channel All-Optical Modulator Exploiting InAs/AlAs Colloidal Quantum Dots

IEEE Access
In the context of advancing photonics technologies, there is an increasing demand for broadband and ultrafast optical modulators to support next-generation telecommunication networks and ultrafast quantum information processing.
Mohammad Faraji, Samiye Matloub, Hannaneh Dortaj   +2 more
doaj   +1 more source

All-optical nano modulator on a silicon chip

Optics Express, 2007
We present an all-optical modulator realized on a silicon chip. The proposed modulator has nano scale dimensions and a high extinction ratio. Its operation principle is based on a spatially non-uniform variation of the absorption of a miniaturized, silicon waveguide - based Mach-Zehnder interferometer (MZI).
O Limon, A Rudnitsky, Z Zalevsky, M Nathan, L Businaro, D Cojoc, A Gerardino   +6 more
openaire   +4 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Ultra-High Electro-Optic Activity Demonstrated in a Silicon-Organic Hybrid (SOH) Modulator

, 2018
Efficient electro-optic (EO) modulators crucially rely on advanced materials that exhibit strong electro-optic activity and that can be integrated into high-speed and efficient phase shifter structures.
Blaicher, Matthias, Dalton, Larry R., Elder, Delwin L., Freude, Wolfgang, Kemal, Juned N., Kieninger, Clemens, Koos, Christian, Kutuvantavida, Yasar, Lauermann, Matthias, Randel, Sebastian, Wolf, Stefan, Zwickel, Heiner   +11 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source