Results 41 to 50 of about 611 (135)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

open access: yesInterdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui   +12 more
wiley   +1 more source

Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers

open access: yesSmall Structures, Volume 7, Issue 3, March 2026.
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis   +7 more
wiley   +1 more source

Device uncertainty propagation in low-ductility RC frames retrofitted with BRBs for seismic risk mitigation [PDF]

open access: yes, 2021
Passive control systems, such as buckling-restrained braces (BRBs), have emerged as efficient tools for seismic response control of new and existing structures by imparting strength and stiffness to buildings, while providing additional high and stable ...
Freddi, F   +3 more
core  

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 242-255, February 2026.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini   +7 more
wiley   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

open access: yesAdvanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck   +4 more
wiley   +1 more source

Environmental Risk Assessment and Anti‐Corrosion Efficacy of Safe‐by‐Design Nitrite‐Based Nanomaterials for Maritime Applications

open access: yesNano Select, Volume 7, Issue 2, February 2026.
The environmental behavior and impact of anti‐corrosion nanoadditives, ZnAl‐NO2 and MgAl‐NO2 layered double hydroxides (LDH), are assessed under marine conditions. These nanomaterials show instability in water but exhibit no or low toxicity to most tested marine species.
Joana Figueiredo   +12 more
wiley   +1 more source

Numerical Investigation of Seismic Response of Hybrid Buckling Restrained Braced Frames [PDF]

open access: yes, 2018
The Conventional buckling restrained braces used in concentrically braced frames are expected to yield in both tension and compression without major degradation of capacity under severe seismic ground motions.
Hoveidae, Nader
core   +1 more source

Influence of the design objectives on the seismic performance of steel moment resisting frames retrofitted with buckling restrained braces [PDF]

open access: yes, 2022
Buckling restrained braces (BRBs) represent an effective strategy for the seismic retrofit of existing steel moment resisting frames (MRFs), as they contribute to increasing the strength and ductility capacity of the structure.
Freddi, Fabio   +1 more
core  

Cognitive Function and Health‐Related Quality of Life in Patients With Multiple Sclerosis: Clinical Evidence From Japan

open access: yesClinical and Experimental Neuroimmunology, Volume 17, Issue 1, February 2026.
ABSTRACT Cognitive impairment is a common symptom of multiple sclerosis (MS) and has a substantial impact on quality of life (QoL). In Japan, cognitive assessment has traditionally lagged behind that in Western countries. With the emerging concept of smoldering‐associated worsening, the importance of longitudinal cognitive monitoring is becoming ...
Shuka Okuda, Juichi Fujimori
wiley   +1 more source

Damage Avoidance Design of Special Truss Girder Frames with Energy Dissipation Devices [PDF]

open access: yes, 2018
An innovative detail that facilitates the use of energy dissipating devices, such as Buckling Restrained Braces (BRBs), is proposed for Special Truss Moment Frames (STMFs).
Linke, Christin
core   +1 more source

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