Results 201 to 210 of about 125,078 (291)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Long-Term Stability Improvements of the Miniature Atomic Clock Through Enhanced Thermal Environmental Control. [PDF]

Sensors (Basel)
Gokie E, Omaraie J, Bandi TN.
europepmc   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Passive air sampling detects environmental DNA transfer from water into air. [PDF]

Sci Rep
Ip YCA, Guri G, Allan EA, Kelly RP.
europepmc   +1 more source

Growing trees on farms: Navigating the goals and values of farmers

People and Nature, EarlyView.
Abstract Agricultural landscapes represent critical contexts for advancing policy objectives related to tree cover expansion. This paper explores how farmers' values influence their willingness or ability to grow trees on farms. Research is based on 49 interviews and two focus groups with farmers in England and draws on two social science research ...
Stephen McConnachie, Robert D. Fish, Holly Harris, Beth B. F. T. Brockett, Harry Marshall, Maddy Pearson, Grace van der Wielen, Bianca Ambrose‐Oji   +7 more
wiley   +1 more source

Enhanced Design and Characterization of a Wearable IMU for High-Frequency Motion Capture. [PDF]

Sensors (Basel)
Valdés-Tirado D, Carro GG, Alvarez JC, Álvarez D, López A.   +4 more
europepmc   +1 more source

Water‐Borne Erosion of Reinforced Polymer Composites: Application to Shallow Offshore Marine Environment

Polymer Composites, EarlyView.
Comparison of experimental and model‐predicted erosion rates for carbon fibre‐reinforced polymer (CFRP) and glass fibre‐reinforced polymer (GFRP) under low‐velocity (2 m/s) and at varying angles and sand concentrations (0.0, 0.05, 0.4 g/L). The results demonstrate good agreement between experimental data and model predictions across different erosive ...
Ali Al‐Darraji, Christopher Lagat, Thaneshan Sapanathan, Peter Butt, Ibukun Oluwoye   +4 more
wiley   +1 more source

Fiber Optic Gyro Random Error Suppression Based on Dual Adaptive Kalman Filter. [PDF]

Micromachines (Basel)
Li H, Liang Z, Zhou Z, Zhang Z, Zhao J, Tian L.   +5 more
europepmc   +1 more source

Digitizing collections to unlock the full potential of palynology: A case study with the Smithsonian palynology collection

PLANTS, PEOPLE, PLANET, EarlyView.
Large palynological collections have been built over decades and contain vital information. However, they are often difficult to access and use effectively. What is the point of having such collections if they are not fully utilizable? To solve this problem, we digitized the Smithsonian palynological collection using both light and confocal microscopy.
Carlos Jaramillo, Surangi W. Punyasena, Daurys de Alba, Roxana Alveo, Angelica Arcila, Jorge Bermudez, Jonatan Bustos, Dayenari Caballero‐Rodriguez, Karen Cardenas, David Caro, Francy Carvajal, Ivonne Marcela Castañeda, Shara Chaves, Carlos D'Apolito, Andres Diaz‐Jaramillo, Laura Diaz, Luisa Gomez, Mauricio León‐Carreño, Paula Lopera, Maria Alejandra Lopez, Priscila Lopez, Luke Mander, Jhonatan Martínez Murcia, Carlos Moreno, Enrique Moreno, Enrique Neyra, Brenda Orosco, Jhon Ortiz, Natalia Ossa, Natalia Ovalle, Carolina Ovalle, Angelo Plata, Ingrid Romero, Bruno Scudeiro, Silane A. F. da Silva Caminha, Axel Tejada‐Fajardo, Vinicius Do Valle, Thiago Wood   +37 more
wiley   +1 more source

Laser power stabilization using conservation law in acoustic optic modulator. [PDF]

Sci Rep
Li E, Ma Q, Wang W, Du B, Liu G.
europepmc   +1 more source