Results 221 to 230 of about 1,163,092 (332)

Targeted loss of heterozygosity in Candida albicans using CRISPR-Cas9 reveals the functional impact of allelic variation. [PDF]

Genetics
Després PC, Gervais NC, Fogal M, Rogers RKJ, Cuomo CA, Shapiro RS.   +5 more
europepmc   +1 more source

DEFINITION OF “STRONG” AND “WEAK” HISTOCOMPATIBILITY ALLELES

, 1968
Regina C. Elandt‐Johnson
openalex   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure. [PDF]

Genome Med
Conil C, Bohlen J, Kroon EE, Jean-Juste MA, Manry J, Chaldebas M, Bean JM, Walsh KF, Dallmann-Sauer M, Rotival M, Seeleuthner Y, Marchal A, Mourelatos H, Fava VM, Zhang P, Kerner G, Skhoun H, Abid A, El Ouazzani H, Rafik A, Bousfiha AA, El Baghdadi J, Wilkinson RJ, Boisson-Dupuis S, Fitzgerald DW, Pape JW, Möller M, Hoal EG, Casanova JL, Abel L, Schurr E, Cobat A.   +31 more
europepmc   +1 more source

Competition between Brown Gene and its Wild-type Allele in <i>Drosophila</i> <i>melanogaster</i>

, 1963
Ken NOZAWA
openalex   +2 more sources

Benchmarking Ploidy Estimation Methods for Bulk and Single‐Cell Whole Genome Sequencing

Advanced Science, EarlyView.
It comprehensively benchmarks computational tools for ploidy estimation from bulk and single‐cell whole‐genome sequencing data. The results highlight the strengths and limitations of each method under different conditions and identify PURPLE and SeCNV show top performance in bulk and single‐cell settings, respectively.
Yawei Song, Zilv Mei, Qijie Zheng, Qingqing Yuan, Yu Liang, Jiaqi Gao, Lang Zhou, Shuheng Wu, Wei Wu   +8 more
wiley   +1 more source

Estimating allele frequencies, ancestry proportions and genotype likelihoods in the presence of mapping bias. [PDF]

G3 (Bethesda)
Günther T, Goldberg A, Schraiber JG.
europepmc   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

Genetics and environmental determinants of Alzheimer's disease and related dementias in older Africans: a narrative review. [PDF]

Genes Environ
Olajide T, Oladapo O, Asogwa C, Olajide G, Oyekan A, Fatola A, Olanrewaju T, Oyegbile D, Ugbo I, Oyoyo H, Kamarudeen R, Famakin O.   +11 more
europepmc   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source