Results 21 to 30 of about 1,163,092 (332)
Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]
, 2012 Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Durkovic, Marina +13 more
core +3 more sources
Frontiers in Plant Science, 2023 Small cardamom (Elettaria cardamomum Maton), the queen of spices, is the third most expensive spice in the world after saffron and vanilla, valued highly for its aroma and taste.
Ambika Baldev Gaikwad +5 more
doaj +1 more source
Зерновое хозяйство России, 2022 The current paper has presented the study and estimation results of winter bread wheat varieties in primary seed production (2019-2021) based on the method of electrophoresis.
T. I. Firsova +3 more
doaj +1 more source
Delimiting Allelic Imbalance of TYMS by Allele-Specific Analysis
Medicine, 2015 Allelic imbalance of thymidylate synthase (TYMS) is attributed to polymorphisms in the 5'- and 3'-untranslated region (UTR). These polymorphisms have been related to the risk of suffering different cancers, for example leukemia, breast or gastric cancer, and response to different drugs, among which are methotrexate glutamates, stavudine, and ...
Angel Carracedo +3 more
openaire +3 more sources
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. [PDF]
, 2009 Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is ...
Bernard, David J +10 more
core +2 more sources
BMC Medical Genetics, 2002 Background We wanted to quantify HLA-A and -B allele and haplotype frequencies in Alabama hemochromatosis probands with HFE C282Y homozygosity and controls, and to compare results to those in other populations.
Barton James C, Acton Ronald T
doaj +1 more source
Allele age and a test for selection on rare alleles [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000 An approximate expression for the probability distribution of the age of a neutral allele as a function of its frequency is derived for a population undergoing arbitrary changes in population size. A simple maximum–likelihood estimator of allele age based on frequency is also obtained.
openaire +3 more sources
CONTRASTING EFFECTS OF AN MDM2 FUNCTIONAL POLYMORPHISM ON TUMOR PHENOTYPES [PDF]
, 2017 Cancer predisposition by the cooperation of genetic variants, such as single nucleotide polymorphisms (SNPs), may be of much greater significance to public health than previously appreciated.
Ortiz, Guadalupe J, IV
core +2 more sources
Selection Mapping Identifies Loci Underpinning Autumn Dormancy in Alfalfa (Medicago sativa). [PDF]
, 2018 Autumn dormancy in alfalfa (Medicago sativa) is associated with agronomically important traits including regrowth rate, maturity, and winter survival. Historical recurrent selection experiments have been able to manipulate the dormancy response.
Brummer, E Charles +3 more
core +3 more sources
Advances in the genetic basis of ischemic stroke [PDF]
Journal of Medical Biochemistry, 2008 As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. About 80% of strokes are ischemic. It is caused by multiple genetic factors, environmental factors, and interactions among these factors.
Stanković Sanja, Majkić-Singh Nada
doaj