Results 41 to 50 of about 818,935 (300)

Understanding Cancer Through the Lens of Epigenetic Inheritance, Allele-Specific Gene Expression, and High-Throughput Technology

Frontiers in Oncology, 2019
Epigenetic information is characterized by its stable transmission during mitotic cell divisions and plasticity during development and differentiation. This duality is in contrast to genetic information, which is stable and identical in all cells in an ...
Maxwell P. Lee
doaj   +1 more source

Allele-specific binding of nuclear proteins to rs2072872 and rs6509.

, 2018
EMSA using 31-bp labeled oligonucleotide probes flanking each SNP (SNP ± 15 bp). Sequences of oligonucleotide probes are listed in S2 Table. The shifted band indicated the interaction between nuclear protein extracted from SKOV3 cells and probes ...
Yukie Takahashi (2642602), Taiki Yamaji (625213), Chizu Tanikawa (135026), Yukihide Momozawa (356235), Mariko Naito (22970), Yaqi Tang (6090740), Norie Sawada (573813), Yoichiro Kamatani (140517), Shoichiro Tsugane (181450), Koichi Matsuda (135032), Atsushi Shimizu (1862), Akimune Fukushima (4247959), Makoto Hirata (1376), Kenji Wakai (174009), Nobuo Fuse (287793), Michiaki Kubo (128298), Varalee Yodsurang (6090737), Asahi Hishida (6090743), Motoki Iwasaki (181395), Atsushi Takahashi (128295), Junichi Sugawara (625364), Yoshinori Murakami (519971), Norihiro Furusyo (6090746)   +22 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers. [PDF]

, 2018
Rapid and specific detection of single nucleotide polymorphisms (SNPs) related to drug resistance in infectious diseases is crucial for accurate prognostics, therapeutics and disease management at point-of-care.
Georgiou, Pantelis, Kenny Malpartida-Cardenas (5811653), Rodriguez-Manzano, Jesus, Jesus Rodriguez-Manzano (2153086), Baum, Jake, Kenny Malpartida-Cardenas, Jake Baum, Ling-Shan Yu (5811656), Ling-Shan Yu, Jake Baum (132234), Pantelis Georgiou (4987574), Pantelis Georgiou, Kesinee Chotivanich (140505), Michael J. Delves (180913), Michael J. Delves, Kesinee Chotivanich, Delves, Michael J, Jesus Rodriguez-Manzano, Yu, Ling-Shan, Chea Nguon, Chotivanich, Kesinee, Nguon, Chea, Delves, Michael, Baum, J, Malpartida-Cardenas, Kenny, Chea Nguon (161886)   +25 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SNP Individual Private Allele Distributions

, 2020
This script was designed to identify the distribution of private alleles among individuals of a population of interest following identification of private alleles among populatios of origin (see https://github.com/slcapel/snp-population-level-private ...
Samantha L. R. Capel
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-wide Identification and Functional Analyses of the 5-O-Glucosyltransferase Family Reveal Its Potential Roles in Anthocyanidin Diglucosides Synthesis of Grape Skins with Vitis amurensis Pedigree

Journal of the American Society for Horticultural Science
Vitis amurensis grape cultivars and hybrids are mainly used to make wines in Northeast Asia with a cold winter. Anthocyanidin glucosylation at 5-O position catalyzed by 5-O-glucosyltransferase (5GT) in grape skins is crucial for color stability of red ...
Lei Zhu, Yunhua Chen, Yunqing Liu, Dandan Li, Yiming Yang, Yuanyuan Wang, Yunting Liu, Mingjie Wang, Jingyu Xu, Xixi Hu   +9 more
doaj   +1 more source

ABCA1 rs1883025 and CYP4F2 rs2108622 Gene Polymorphism Association with Age-Related Macular Degeneration and Anti-VEGF Treatment

Medicina, 2021
Background and Objectives: The age-related macular degeneration (AMD) pathophysiology is multifactorial, as it consists of interactions between aging, genetic, and environmental factors.
Ruta Mockute, Alvita Vilkeviciute, Vilma Jurate Balciuniene, Reda Zemaitiene, Rasa Liutkeviciene   +4 more
doaj   +1 more source

Allele-specific mutation bias is caused by allele-specific chromatin modifications.

, 2018
(A) The degree of methylated alleles correlates with allele-specific mutation bias across three imprinted target sites (sgInpp5f_v2, sgKvDMR1, sgImpact) in two mESC lines.
Tracy Ballinger (6078908), Martijn J. E. Kelder (6078911), Keerthi Thelakkad Chathoth (6078902), Robert Feil (28669), Sébastien Lalevée (6078914), Andrew J. Wood (18644), Gillian C. Taylor (6078905), Alison Meynert (2734069), Ildem Sanli (6078917), Eirini M. Kallimasioti-Pazi (6078899)   +9 more
core   +1 more source