Results 41 to 50 of about 876,901 (295)
Frontiers in Oncology, 2019 Epigenetic information is characterized by its stable transmission during mitotic cell divisions and plasticity during development and differentiation. This duality is in contrast to genetic information, which is stable and identical in all cells in an ...
Maxwell P. Lee
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Allele-specific binding of nuclear proteins to rs2072872 and rs6509.
, 2018 EMSA using 31-bp labeled oligonucleotide probes flanking each SNP (SNP ± 15 bp). Sequences of oligonucleotide probes are listed in S2 Table. The shifted band indicated the interaction between nuclear protein extracted from SKOV3 cells and probes ...
Yukie Takahashi (2642602) +22 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers. [PDF]
, 2018 Rapid and specific detection of single nucleotide polymorphisms (SNPs) related to drug resistance in infectious diseases is crucial for accurate prognostics, therapeutics and disease management at point-of-care.
Georgiou, Pantelis +25 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
SNP Individual Private Allele Distributions
, 2020 This script was designed to identify the distribution of private alleles among individuals of a population of interest following identification of private alleles among populatios of origin (see https://github.com/slcapel/snp-population-level-private ...
Samantha L. R. Capel
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Allele-Specific Chemical Rescue of Histone Demethylases Using Abiotic Cofactors
, 2021 Closely related protein families evolved from common ancestral genes present a significant hurdle in developing member- and isoform-specific chemical probes, owing to their similarity in fold and function.
Kathryn Hinkelman +11 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.
, 2017 Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here,
N. J. Birkbak (7691705) +12 more
core +6 more sources
Journal of the American Society for Horticultural ScienceVitis amurensis grape cultivars and hybrids are mainly used to make wines in Northeast Asia with a cold winter. Anthocyanidin glucosylation at 5-O position catalyzed by 5-O-glucosyltransferase (5GT) in grape skins is crucial for color stability of red ...
Lei Zhu +9 more
doaj +1 more source