Results 61 to 70 of about 876,901 (295)

Analysis of tissue-specific & allele-specific DNA methylation [PDF]

, 2010
Epigenetic mechanisms such as histone modifications and DNA methylation extend the information of the underlying genomic DNA sequence. Understanding cell type-specific epigenetic codes on a global level is a major challenge after the sequencing of the ...
Schilling, Elmar
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effect of genetic specifics of patients on myocardial contractility after acute myocardial infarction: a literature review

Российский кардиологический журнал, 2022
In this literature review, we analyzed studies on the influence of genetic specifics of patients on the restoration of myocardial contractility after acute myocardial infarction.
S. E. Golovenkin, S. Yu. Nikulina, M. G. Bubnova, V. N. Maksimov   +3 more
doaj   +1 more source

Allele-specific Taqman analysis of human X linked genes during cell fusion-mediated pluripotent reprogramming.xlsx

, 2016
Allele-specific Taqman analysis of a subset of X-linked genes in hF clones and upon mESC fusion-mediated reprogramming.Details of the dataset and figure plots are reported in Genome Biology paper entitled "Allele-specific analysis of cell fusion-mediated
Irene Cantone (3363740)
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

An Allele Based-Approach for Internet of Transactional Things Service Placement in Intelligent Edge Environments

IoT
The rapid expansion of the Internet of Things (IoT) has steered in a new generation of connectivity and data-driven decision-making across diverse industrial sectors. As IoT deployments continue to expand, the need for robust and reliable data management
Driss Riane, Widad Ettazi, Mahmoud Nassar   +2 more
doaj   +1 more source

Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis

Parasite, 2021
Head lice (Pediculus humanus capitis) are one of the most common insects causing infestations in humans worldwide, and infestation is associated with adverse socio-economic and public health effects. The development of genetic insensitivity (e.g., target
Mohammadi Jalal, Azizi Kourosh, Alipour Hamzeh, Kalantari Mohsen, Bagheri Masoumeh, Shahriari-Namadi Marzieh, Ebrahimi Saeedeh, Moemenbellah-Fard Mohammad D.   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Efficacy of treatment of extensive drug resistant tuberculosis in patients with different genotypes in the biotransformation enzyme genes of CYP2B6 and NAT2

Туберкулез и болезни лёгких, 2020
The objective of the study: to evaluate the efficacy of treatment of extensive drug resistant tuberculosis (XDR-TB) in patients with different genotypes in the biotransformation system NAT2 (rs1041983, rs1799930, rs1799931, rs1801280) and CYP2B6 genes ...
M. M. Yunusbаevа, L. Ya. Borodinа, F. S. Bilаlov, R. A. Shаripov, T. R. Nаsibullin, B. B. Yunusbаev   +5 more
doaj   +1 more source

Development of Single Nucleotide Polymorphism (SNP)-Based Triplex PCR Marker for Serotype-specific Escherichia coli Detection

Pathogens, 2022
Single-nucleotide polymorphisms (SNPs) are one of the most common forms of genetic variation and as such are powerful tools for the identification of bacterial strains, their genetic diversity, phylogenetic analysis, and outbreak surveillance.
Md-Mafizur Rahman, Sang-Jin Lim, Yung-Chul Park   +2 more
doaj   +1 more source