Results 61 to 70 of about 1,128,567 (287)

ABCA1 rs1883025 and CYP4F2 rs2108622 Gene Polymorphism Association with Age-Related Macular Degeneration and Anti-VEGF Treatment

Medicina, 2021
Background and Objectives: The age-related macular degeneration (AMD) pathophysiology is multifactorial, as it consists of interactions between aging, genetic, and environmental factors.
Ruta Mockute, Alvita Vilkeviciute, Vilma Jurate Balciuniene, Reda Zemaitiene, Rasa Liutkeviciene   +4 more
doaj   +1 more source

Invasive Allele Spread under Preemptive Competition

, 2005
We study a discrete spatial model for invasive allele spread in which two alleles compete preemptively, initially only the "residents" (weaker competitors) being present.
A. Gandhi, A.N. Kolmogorov, A.N. Kolmogorov, D. ben-Avraham, D.E. Taneyhill, D.W. Yu, G. Korniss, H.L. Richards, H.M. Duiker, J.B. Shurin, J.D. Murray, L. O’Malley, M. Avrami, M. Karttunen, P. Amarasekare, P.A. Rikvold, R.A. Fisher, R.A. Ramos, W._.A. Johnson, Y. Ishibashi   +19 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genome-wide Identification and Functional Analyses of the 5-O-Glucosyltransferase Family Reveal Its Potential Roles in Anthocyanidin Diglucosides Synthesis of Grape Skins with Vitis amurensis Pedigree

Journal of the American Society for Horticultural Science
Vitis amurensis grape cultivars and hybrids are mainly used to make wines in Northeast Asia with a cold winter. Anthocyanidin glucosylation at 5-O position catalyzed by 5-O-glucosyltransferase (5GT) in grape skins is crucial for color stability of red ...
Lei Zhu, Yunhua Chen, Yunqing Liu, Dandan Li, Yiming Yang, Yuanyuan Wang, Yunting Liu, Mingjie Wang, Jingyu Xu, Xixi Hu   +9 more
doaj   +1 more source

The Effects of Population Size Histories on Estimates of Selection Coefficients from Time-Series Genetic Data. [PDF]

, 2016
Many approaches have been developed for inferring selection coefficients from time series data while accounting for genetic drift. These approaches have been motivated by the intuition that properly accounting for the population size history can ...
Jewett, Ethan, Song, Yun, Steinrücken, Matthias   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Development of a Providencia stuartii multilocus sequence typing scheme

Frontiers in Microbiology
IntroductionThe Providencia genus is assuming greater clinical relevance among infections caused by Enterobacterales also because of its intrinsic and acquired resistance to last-resort antibiotics. However, despite having been known and studied for over
Gabriele Arcari, Gabriele Arcari, Alice De Francesco, Riccardo Polani, Alessandra Carattoli, Valerio Capitani   +5 more
doaj   +1 more source

Association of the AspP298Asn polymorphism in the MC4R gene with fattening productivity of immunologically castrated and uncastrated gilts

Біологія тварин, 2023
The study was aimed at establishing the presence of MC4R (c.1426 A>G) gene polymorphism among the population of immunologically castrated and native gilts (Large White × Landrace) × Maxgro.
Y. Pocherniaieva, K. Pochernyayev, I. Bankovska   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Advances in the genetic basis of ischemic stroke [PDF]

Journal of Medical Biochemistry, 2008
As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. About 80% of strokes are ischemic. It is caused by multiple genetic factors, environmental factors, and interactions among these factors.
Stanković Sanja, Majkić-Singh Nada
doaj