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Allele-specific Taqman analysis of human X linked genes during cell fusion-mediated pluripotent reprogramming.xlsx

, 2016
Allele-specific Taqman analysis of a subset of X-linked genes in hF clones and upon mESC fusion-mediated reprogramming.Details of the dataset and figure plots are reported in Genome Biology paper entitled "Allele-specific analysis of cell fusion-mediated
Irene Cantone (3363740)
core +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source

An Allele Based-Approach for Internet of Transactional Things Service Placement in Intelligent Edge Environments

IoT
The rapid expansion of the Internet of Things (IoT) has steered in a new generation of connectivity and data-driven decision-making across diverse industrial sectors. As IoT deployments continue to expand, the need for robust and reliable data management
Driss Riane, Widad Ettazi, Mahmoud Nassar +2 more
doaj +1 more source

Frequency of pyrethroid resistance in human head louse treatment: systematic review and meta-analysis

Parasite, 2021
Head lice (Pediculus humanus capitis) are one of the most common insects causing infestations in humans worldwide, and infestation is associated with adverse socio-economic and public health effects. The development of genetic insensitivity (e.g., target
Mohammadi Jalal +7 more
doaj +1 more source

Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay

, 2022
Sequencing of cell-free DNA (cfDNA) in cancer patients’ plasma offers a minimally-invasive solution to detect tumor cell genomic alterations to aid real-time clinical decision-making.
Lena Karapagniotou (12906311) +250 more
core +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source

Efficacy of treatment of extensive drug resistant tuberculosis in patients with different genotypes in the biotransformation enzyme genes of CYP2B6 and NAT2

Туберкулез и болезни лёгких, 2020
The objective of the study: to evaluate the efficacy of treatment of extensive drug resistant tuberculosis (XDR-TB) in patients with different genotypes in the biotransformation system NAT2 (rs1041983, rs1799930, rs1799931, rs1801280) and CYP2B6 genes ...
M. M. Yunusbаevа +5 more
doaj +1 more source

Development of Single Nucleotide Polymorphism (SNP)-Based Triplex PCR Marker for Serotype-specific Escherichia coli Detection

Pathogens, 2022
Single-nucleotide polymorphisms (SNPs) are one of the most common forms of genetic variation and as such are powerful tools for the identification of bacterial strains, their genetic diversity, phylogenetic analysis, and outbreak surveillance.
Md-Mafizur Rahman, Sang-Jin Lim, Yung-Chul Park +2 more
doaj +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source

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polymorphism
alleles

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haplotype
gene

single nucleotide polymorphism
hla
genetic diversity