Results 61 to 70 of about 1,186,851 (331)

Advances in the genetic basis of ischemic stroke [PDF]

Journal of Medical Biochemistry, 2008
As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. About 80% of strokes are ischemic. It is caused by multiple genetic factors, environmental factors, and interactions among these factors.
Stanković Sanja, Majkić-Singh Nada
doaj  

Novel Schizophrenia Risk Gene TCF4 Influences Verbal Learning and Memory Functioning in Schizophrenia Patients [PDF]

, 2011
Background: Recently, a role of the transcription factor 4 (TCF4) gene in schizophrenia has been reported in a large genome-wide association study. It has been hypothesized that TCF4 affects normal brain development and TCF4 has been related to different
Aleman A, Anna Schuhmacher, Bogerts B, Dan Rujescu, Hans-Jürgen Möller, Heinz Häfner, Ingo Frommann, Leonhard Lennertz, Martin W. Landsberg, Michael Wagner, Petra Franke, Pitt D, Rainald Mössner, Saykin AJ, Stefánsson H, Svenja Schulze-Rauschenbach, Whyte MC, Wolfgang Gaebel, Wolfgang Maier, Wolfgang Wölwer, Wright IC   +20 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Mainstreaming production and nutrient resilience of vegetable crops in megacities: pre-breeding for terrace cultivation

Frontiers in Plant Science, 2023
Modern megacities offer convenient lifestyles to their citizens. However, agriculture is becoming increasingly vulnerable, especially during unexpected public health emergencies such as pandemics.
Kun Ma, Yuan Yuan, Caochuang Fang
doaj   +1 more source

Asymptotics of the allele frequency spectrum associated with the Bolthausen-Sznitman coalescent

, 2007
We work in the context of the infinitely many alleles model. The allelic partition associated with a coalescent process started from n individuals is obtained by placing mutations along the skeleton of the coalescent tree; for each individual, we trace ...
Basdevant, Anne-Laure, Goldschmidt, Christina   +1 more
core   +5 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

An Allele Based-Approach for Internet of Transactional Things Service Placement in Intelligent Edge Environments

IoT
The rapid expansion of the Internet of Things (IoT) has steered in a new generation of connectivity and data-driven decision-making across diverse industrial sectors. As IoT deployments continue to expand, the need for robust and reliable data management
Driss Riane, Widad Ettazi, Mahmoud Nassar   +2 more
doaj   +1 more source

Effect of rs109262355 mutation in FYN binding protein gene on lactation performance of Holstein cows in southern China

浙江大学学报. 农业与生命科学版, 2023
This study aimed to investigate the effects of FYN binding protein (FYB) gene mutation on lactation performance of Holstein cows in southern China. The lactation traits of 785 Holstein cows from 2014 to 2020 were collected, and the single nucleotide ...
LIU Chenhui, WU Hailong, CHENG Lei, YU Jie, XIA Yu, XIANG Min, HU Xiuzhong, WANG Dingfa, TAO Bifei   +8 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules. [PDF]

, 2001
Ly49 receptor genes are expressed by subsets of natural killer (NK) cells in an overlapping fashion, accounting for the capacity of NK subsets to attack host cells that have selectively downregulated self-major histocompatibility complex (MHC) class I ...
Hanke, T, Jamieson, A, RAULET, David H., Takizawa, H, Tanamachi, D   +4 more
core   +1 more source