Results 11 to 20 of about 5,554,112 (362)
Inference of population splits and mixtures from genome-wide allele frequency data [PDF]
PLoS Genetics, 2012 Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model for inferring
A Keinan +66 more
core +7 more sources
Allele frequency dynamics in a pedigreed natural population [PDF]
Proceedings of the National Academy of Sciences, 2018 A central goal of population genetics is to understand how genetic drift, natural selection, and gene flow shape allele frequencies through time. However, the actual processes underlying these changes—variation in individual survival, reproductive success, and movement—are often difficult to quantify.
Nancy Chen +7 more
openaire +7 more sources
Bayesian inference of natural selection from allele frequency time series [PDF]
Genetics, 2016 The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency time series to detect and estimate natural selection.
Evans, Steven N. +2 more
core +2 more sources
Genome Biology, 2021 Background Oncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials.
W. Jones +73 more
semanticscholar +1 more source
Blood Advances, 2020 TP53 mutations are associated with adverse outcomes and shorter response to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS). Limited data have evaluated the impact of the type, number, and patterns of TP53 mutations in response outcomes ...
G. Montalban-Bravo +21 more
semanticscholar +1 more source
A variant-centric perspective on geographic patterns of human allele frequency variation
eLife, 2020 A key challenge in human genetics is to understand the geographic distribution of human genetic variation. Often genetic variation is described by showing relationships among populations or individuals, drawing inferences over many variants.
Arjun Biddanda, D. P. Rice, J. Novembre
semanticscholar +1 more source
ALLELE FREQUENCY OF GLUTENIN SUBUNITS AND GLU-1 QUALITY SCORES IN SOME TURKISH BREAD WHEAT LANDRACES
Trakya University Journal of Natural Sciences, 2020 There are eight centers of origin for cultivated plants and Turkey is located in the interception of two of these centers, the Near East and the Mediterranean.
Ridvan Temızgul, Mikail Akbulut
doaj +1 more source
Tikrit Journal of Pure Science, 2023 A genetic study for the trait of Darwin's tubercle in two ways : first , on a sample consisted of 52 family from Tikrit city in governorate Salah AL-Dein and 125 individual from their sons and 63 family from governorate of Kirkuk and 188 individual from
Adel Fawzy Shihab, Marwa Amer Shakir
doaj +1 more source
Population Difference in Allele Frequency of HLA-C*05 and Its Correlation with COVID-19 Mortality
Viruses, 2020 Background: coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which ...
A. Sakuraba, H. Haider, Toshiro Sato
semanticscholar +1 more source
The Impact of Variant Allele Frequency in EGFR Mutated NSCLC Patients on Targeted Therapy
Frontiers in Oncology, 2021 EGFR mutations represent the most common currently targetable oncogenic driver in non-small cell lung cancer. There has been tremendous progress in targeting this alteration over the course of the last decade, and third generation tyrosine kinase ...
Alex Friedlaender +4 more
doaj +1 more source