Bayesian Inference of Natural Selection from Allele Frequency Time Series [PDF]
Genetics, 2016 The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency time series to detect and estimate natural selection.
J. Schraiber, S. Evans, M. Slatkin
semanticscholar +3 more sources
Non-equilibrium theory of the allele frequency spectrum [PDF]
Theoretical Population Biology, 2007 A forward diffusion equation describing the evolution of the allele frequency spectrum is presented. The influx of mutations is accounted for by imposing a suitable boundary condition. For a Wright-Fisher diffusion with or without selection and varying population size, the boundary condition is $\lim_{x \downarrow 0} x f(x,t)= (t)$, where $f(\cdot,t)
Montgomery Slatkin +2 more
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Kinetic FP-TDI Assay for SNP Allele Frequency Determination [PDF]
BioTechniques, 2003 Strategies for identifying genetic risk factors in complex diseases by association studies require the comparison of allele frequencies of numerous SNPs between affected and control populations.
Ming Xiao +2 more
doaj +3 more sources
High throughput automated allele frequency estimation by pyrosequencing. [PDF]
PLoS ONE, 2008 Pyrosequencing is a DNA sequencing method based on the principle of sequencing-by-synthesis and pyrophosphate detection through a series of enzymatic reactions.
Julie Doostzadeh +8 more
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Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed. [PDF]
, 2020 BackgroundCatastrophic fractures are among the most common cause of fatalities in racehorses. Several factors, including genetics, likely contribute to increased risk for fatal injuries.
Arthur, R +6 more
core +1 more source
A variant-centric perspective on geographic patterns of human allele frequency variation
eLife, 2020 A key challenge in human genetics is to understand the geographic distribution of human genetic variation. Often genetic variation is described by showing relationships among populations or individuals, drawing inferences over many variants.
Arjun Biddanda, D. P. Rice, J. Novembre
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ALLELE FREQUENCY OF GLUTENIN SUBUNITS AND GLU-1 QUALITY SCORES IN SOME TURKISH BREAD WHEAT LANDRACES
Trakya University Journal of Natural Sciences, 2020 There are eight centers of origin for cultivated plants and Turkey is located in the interception of two of these centers, the Near East and the Mediterranean.
Ridvan Temızgul, Mikail Akbulut
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Population Difference in Allele Frequency of HLA-C*05 and Its Correlation with COVID-19 Mortality
Viruses, 2020 Background: coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which ...
A. Sakuraba, H. Haider, Toshiro Sato
semanticscholar +1 more source
The Impact of Variant Allele Frequency in EGFR Mutated NSCLC Patients on Targeted Therapy
Frontiers in Oncology, 2021 EGFR mutations represent the most common currently targetable oncogenic driver in non-small cell lung cancer. There has been tremendous progress in targeting this alteration over the course of the last decade, and third generation tyrosine kinase ...
Alex Friedlaender +4 more
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Frontiers in Immunology, 2023 Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić +4 more
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