Results 241 to 250 of about 1,221,818 (402)

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Landscape of rare-allele variants in cultivated and wild soybean genomes. [PDF]

Plant Genome
Liu Z, Shi X, Yang Q, Li Y, Yang C, Zhang M, An YC, Nguyen HT, Yan L, Song Q.   +9 more
europepmc   +1 more source

MATING BEHAVIOR AND FITNESS AS A FUNCTION OF SINGLE ALLELE DIFFERENCES IN EPHESTIA KÜHNIELLA Z. [PDF]

, 1967
William B. Cotter
openalex   +1 more source

Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles

Proceedings of the National Academy of Sciences of the United States of America, 2015
Daniel Gadala-Maria, Gur Yaari, Mohamed Uduman, S. Kleinstein   +3 more
semanticscholar   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

Predicting MHC-I ligands across alleles and species: how far can we go? [PDF]

Genome Med
Tadros DM, Racle J, Gfeller D.
europepmc   +1 more source

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Science, 2014
T. Raj, K. Rothamel, S. Mostafavi, Chun Jimmie Ye, Mark N. Lee, J. Replogle, T. Feng, Michelle H. Lee, Natasha Asinovski, I. Frohlich, S. Imboywa, Alina Von Korff, Y. Okada, N. Patsopoulos, Scott P. Davis, C. McCabe, H. Paik, G. Srivastava, S. Raychaudhuri, D. Hafler, D. Koller, A. Regev, N. Hacohen, D. Mathis, C. Benoist, B. Stranger, P. D. De Jager   +26 more
semanticscholar   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source

Fully Phased Population-Prevalent East African Cattle BoLA-I Alleles Determined Using PacBio HiFi Long-Read Sequencing Represent Five Novel Specificities With Distinctive Peptide Binding Potential. [PDF]

HLA
Obara I, Sandro A, Elati K, Conneley T, Nielsen M, Githaka N, Nanteza A, Bishop R, Nijhof A.   +8 more
europepmc   +1 more source

ROLE OF LINKAGE IN GENE FREQUENCY CHANGE OF COAT COLOR ALLELES IN MICE [PDF]

, 1968
Philip W. Hedrick, R. E. Comstock
openalex   +1 more source