Results 41 to 50 of about 1,221,818 (402)

Introgression of Maize Lethal Necrosis Resistance Quantitative Trait Loci Into Susceptible Maize Populations and Validation of the Resistance Under Field Conditions in Naivasha, Kenya

open access: yesFrontiers in Plant Science, 2021
Maize lethal necrosis (MLN), resulting from co-infection by maize chlorotic mottle virus (MCMV) and sugarcane mosaic virus (SCMV) can cause up to 100% yield losses in maize in Africa under serious disease conditions.
Luka A. O. Awata   +12 more
doaj   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh   +5 more
wiley   +1 more source

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

open access: yesScience Advances, 2018
Ribosomal RNA sequence variants are conserved, exhibit tissue-specific expression, and are found in actively translating ribosomes. The ribosome, the integration point for protein synthesis in the cell, is conventionally considered a homogeneous ...
Matthew M. Parks   +10 more
semanticscholar   +1 more source

Fitness costs associated with evolved herbicide resistance alleles in plants [PDF]

open access: yes, 2009
Predictions based on evolutionary theory suggest that the adaptive value of evolved herbicide resistance alleles may be compromised by the existence of fitness costs.
Neve, Paul   +2 more
core   +1 more source

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

Combination of HLA-DRB1 alleles as a factor causing risks of sporadic congenital heart defects and congenital malformations without chromosome diseases

open access: yesAnaliz Riska Zdorovʹû, 2021
Congenital heart defects are anomalies that are becoming more and more frequent every year. Their specific weight is the highest among all the defects and malformations in fetus.
A.V. Shabaldin   +4 more
doaj   +1 more source

Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

open access: yesJournal of Biological Chemistry, 1995
Approximately 50% of Helicobacter pylori strains produce a cytotoxin, encoded by vacA, that induces vacuolation of eukaryotic cells. Analysis of a clinically isolated tox strain (Tx30a) indicated secretion of a 93-kDa product from a 3933-base pair vacA ...
J. Atherton   +5 more
semanticscholar   +1 more source

Reliability assessment of null allele detection: inconsistencies between and within different methods [PDF]

open access: yes, 2014
Microsatellite loci are widely used in population genetic studies, but the presence of null alleles may lead to biased results. Here we assessed five methods that indirectly detect null alleles, and found large inconsistencies among them.
Avise   +31 more
core   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino   +16 more
wiley   +1 more source

Risk alleles for multiple sclerosis identified by a genomewide study.

open access: yesNew England Journal of Medicine, 2007
BACKGROUND Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. METHODS We used DNA microarray technology to identify common
D. Hafler   +18 more
semanticscholar   +1 more source

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