Results 51 to 60 of about 621,836 (296)

Assessment of rhesus and kell blood group antigens, phenotypes, and their allelic frequencies in North Indian blood donors

Asian Journal of Transfusion Science, 2020
Background: Prevalence of rhesus (Rh) and Kell antigens in a population vary with race, ethnicity, and geographical location. With advances in immunohematology, non-D antigens, and their corresponding antibodies are increasingly being found to be ...
Sangeeta Pahuja, Sonal Jain, Manupriya Nain, Ruchika Goel, Shivali Sehgal, Manjula Jain   +5 more
doaj   +1 more source

RHD Positive Haplotype in D Negative Omani Blood Donor

Oman Medical Journal, 2023
The frequency of Rhesus D negative blood group in Omanis is 8.35% but the molecular background of this phenotype is unknown in the Omani population. The Rhesus D negative phenotype has a high molecular diversity.
Mujtaba Al Lawati, Badriya Al Balushi
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of naturally occurring alleles of rpoS in Escherichia coli [PDF]

, 2008
Sigma S (RpoS), encoded by rpoS, is a subunit of RNA polymerase holoenzyme that controls the expression of many genes in stationary phase of various gram negative bacteria.
Gyewu, Daniel
core  

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.

, 2006
To identify low penetrance susceptibility alleles for colorectal cancer (CRC), we genotyped 1467 non-synonymous SNPs mapping to 871 candidate cancer genes in 2575 cases and 2707 controls.
Webb, Emily L, Rachid El Galta, Wood, W, Fletcher, O, Emily L. Webb, Houlston, Richard S, Gabrielle S. Sellick, Gray, Richard, Gray, R, Penegar, S, Nichola Johnson, Tomlinson, I, Peto, Julian, Withey, L, Laura Withey, Johnson, Nichola, Fletcher, Olivia, Qureshi, Mobshra, Sellick, Gabrielle S, Webb, EL, Qureshi, M, Rudd, Matthew F, Bethke, L, Steven Penegar, El Galta, R, Houlson, RS, Bethke, Lara, Rudd, MF, Mobshra Qureshi, Houlston, RS, Richard Gray, Peto, J, Tomlinson, Ian, El Galta, Rachid, Johnson, N, Sellick, GS, Wood, Wendy, Ian Tomlinson, Penegar, Steven, Galta, EL, Withey, Laura, Wendy Wood, Olivia Fletcher, Richard S. Houlston, Matthew F. Rudd, Julian Peto, Lara Bethke   +46 more
core   +1 more source

HLA diversity in the Russian population assessed by next generation sequencing

Медицинская иммунология, 2021
Next generation sequencing is used to determine full-length sequences of HLA genes at the 4-field (allelic) resolution. The study was aimed at determining frequency and diversity of HLA alleles in a cohort of blood donors from the Registry of the ...
E. G. Khamaganova, E. A. Leonov, A. R. Abdrakhimova, S. P. Khizhinskiy, T. V. Gaponova, V. G. Savchenko   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Are minor alleles more likely to be risk alleles? [PDF]

, 2018
Background Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors.
Patwardhan, Anil, Chen, Richard, Dexter Hadley, Butte, Atul J, Sikora-Wohlfeld, Weronika, Kamatani, Naoyuki, Takashi Kido, Kido, Takashi, Weronika Sikora-Wohlfeld, Atul J. Butte, Marina Sirota, Kodama, Keiichi, Kikuchi, Shinichi, Minae Kawashima, Anil Patwardhan, Hadley, Dexter, Keiichi Kodama, Shinichi Kikuchi, Kawashima, Minae, Naoyuki Kamatani, Richard Chen, Sirota, Marina   +21 more
core   +1 more source