Results 51 to 60 of about 633,120 (300)
HLA diversity in the Russian population assessed by next generation sequencing
Медицинская иммунология, 2021 Next generation sequencing is used to determine full-length sequences of HLA genes at the 4-field (allelic) resolution. The study was aimed at determining frequency and diversity of HLA alleles in a cohort of blood donors from the Registry of the ...
E. G. Khamaganova +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Standardized SSR allele naming and binning among projects
BioTechniques, 2010 Simple sequence repeats (SSRs) have proven to be extremely valuable DNA markers for genetic mapping and population genetic analyses. However, data collected across laboratories or even within laboratories are difficult to combine due to challenges in ...
Dennis L. Deemer, C. Dana Nelson
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Alignment of pneumococcal BriC alleles.
, 2018 Alignment of 19 BriC alleles identified in the database of 4,034 pneumococcal genomes. Alleles are labeled 1A-1S followed by the number of representatives in the database (total 3,976).
N. Luisa Hiller (48998) +9 more
core +1 more source
Agricultura Tropica et SubtropicaCowpea is an important legume, and its wild relatives could be reliable sources of favorable alleles for genetic diversity and improvement of important traits.
Olayiwola Richard Oluseyi +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MHCcluster output for risk and control alleles.
, 2020 Specificity tree shows clustering of alleles and heat map shows the similarity between the binding motifs of each B allele, comparing known risk and possible risk (B*38:01) alleles (highlighted in blue) with selected controls.
Andrew R. Jones (2217223) +3 more
core +1 more source
Ribogospodarsʹka Nauka Ukraïni, 2016 Purpose. Study of the peculiarities of the genetic structure based on genetic-biochemical markers in age-1+ and 2+ rainbow trout of the fish farm “Sloboda Banilov”, Chernivtsi region Methodology.
Р. Mendrishora +2 more
doaj +1 more source