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Immunology and Allergy Clinics of North America, 2011 For the past century, subcutaneous allergen-specific immunotherapy has been the state-of-the-art treatment for IgE-mediated allergic disease. Current research on allergen-specific immunotherapy is focused on enhancing its efficacy, safety, and patient convenience with the goal of offering a broadly accepted treatment option. There is a growing interest
Gabriela Senti, Seraina von Moos
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Advances in allergen-specific immunotherapy
Expert Opinion on Biological Therapy, 2005 Atopic disease affects approximately 30% of the population in western society. Allergen-specific immunotherapy (SIT) is the only treatment with a long-term effect available at the present time, and has been used successfully in the treatment of a number of allergies for almost 100 years. Despite this success, there is great demand for safer, faster and
Verhagen J, Taylor A, Akdis CA, Akdis M
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Allergen-Specific Immunotherapy
, 2014 Specific immunotherapy was introduced for the treatment of grass pollen-induced hay fever in 1911. The treatment was soon extended to other pollens as well as perennial allergens, and to the treatment of bronchial asthma. Definitive studies of its efficacy for both rhinitis and asthma came only many decades later. Understanding gradually emerged of the
Harold S, Nelson, Philip S, Norman
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Allergen-specific Immunotherapy in Atopic Eczema
Current Allergy and Asthma Reports, 2011 Aeroallergens are relevant eliciting factors of allergic rhinoconjunctivitis and bronchial asthma but also of atopic eczema. The use of allergen-specific immunotherapy as in respiratory atopic diseases is controversial in patients with atopic eczema, but refined diagnostic methods to characterize subgroups of patients with relevant allergies and the ...
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Advances in Allergen-Specific Immunotherapy
Current Drug Targets, 2009After several decades of controversies, allergen specific immunotherapy (SIT) was recognized as an effective treatment for respiratory and hymenoptera allergy by the World Health Organization in 1998. SIT involves the administration (usually subcutaneous) of increasing doses of allergen in order to achieve a hyposensitization. Moreover, SIT is the only
PASSALACQUA, GIOVANNI +2 more
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Arguing the Misconceptions in Allergen-Specific Immunotherapy
Immunotherapy, 2014Allergen immunotherapy (AIT) has a clear evidence of efficacy and safety, as shown by a number of meta-analyses. However, a number of issues limit the use of AIT, many of them being not actually supported by solid data from the literature. In particular, several contraindications to AIT deserve to be argued, being needed to accurately balance in single
RIDOLO, Erminia +4 more
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Regulatory Cells in Allergen-Specific Immunotherapy
Immunotherapy, 2012Allergen-specific immunotherapy (SIT) is currently the best available curative treatment in allergies and has been used for the treatment of patients for the past 100 years. The formation of a Th2 cell predominant inflammation in addition to production of allergen-specific IgE, the attraction of proinflammatory cells and the degranulation of effector ...
Soyka, M B, Holzmann, D, Akdis, C A
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Allergen-specific immunotherapy
Immunology Letters, 2009Allergy is a significant health problem in industrialized countries and its prevalence is continually on the increase: In 1906, when Clemens von Pirquet introduced the term "allergy" to describe overwhelming pathological reactions of the body caused by contact with antigens, less than 1% of the population were affected.
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The effect of allergen-specific immunotherapy on offspring
Allergy and Asthma Proceedings, 2016The incidence of allergic diseases has increased worldwide. Thus, there is a need for effective primary prevention of allergies.The aim of the present study was to examine how allergen-specific immunotherapy (ASIT) affects the development of allergies in the generation of children whose parents were subjected to this method of treatment.A total of 194 ...
Andrzej, Bozek +2 more
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Allergen-Specific Immunotherapy (ASIT)
2019The reader can find the up-to-date information on allergens and their nomenclature, subcutaneous and sublingual methods of allergen-specific therapy (ASIT), mechanisms of action of ASIT, clinical efficacy, etc. There is an explanation why the ASIT as a modality of treatment for atopic allergic conditions is more important and be predominant in the near
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