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Allergens and Allergen Immunotherapy
1998Allergen immonotherapy in historical perpective definition of an allergen aerobiology allergen nomenclature tree pollen allergens grass pollen allergens weed pollen allergens mold allergens biting insect allergens mite allergens cockroach and other inhalent insect allergens food allergens latex allergens drug allergens, haptens and anaphylatoxins ...
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The advent of recombinant allergens and allergen cloning [PDF]
Journal of Allergy and Clinical Immunology, 2011 When the allergen nomenclature system was adopted in 1986, allergens were identified by their behavior on electrophoresis and chromatography and by reactivity to shared antisera. Not only was this unsatisfactory for standardization, but the processes of allergic sensitization and immunotherapy could not be studied in the framework of antigen processing
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The Function of Allergens May Determine Allergenicity
1996Allergenicity of an antigen in terms of Type-1 allergy has always been described as the ability of a given protein to bind to specific IgE antibodies and the potency of these allergens to crosslink cellbound IgE to induce mediator release like histamine in basophils or mast cells.
Max Schlaak +4 more
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Allergen immunotherapy with cat allergen peptides
Springer Seminars in Immunopathology, 2004Desensitising therapy for allergic diseases has changed little over almost a century of practice. Administration of increasing doses of extracts of allergen source material has been shown to be reproducibly effective when patients are carefully selected and appropriate concentrations of allergen employed.
A. Barry Kay, Mark Larché
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Allergen-Specific Immunotherapy with Recombinant Allergens
2011Subcutaneous immunotherapy is a well-documented treatment of allergic rhinitis and asthma. The major limitation is the risk of anaphylactic side effects. The documentation of clinical efficacy is based on crude allergenic extracts sometimes containing varying amounts of individual allergens including allergens to which the patient may not be sensitized.
Gabrielle Pauli, Hans-Jørgen Malling
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Allergy, 2003
Allergies represent a significant medical and industrial problem. Molecular and clinical data on allergens are growing exponentially and in this article we have reviewed nine specialized allergen databases and identified data sources related to protein allergens contained in general purpose molecular databases.
Nikolai Petrovsky +6 more
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Allergies represent a significant medical and industrial problem. Molecular and clinical data on allergens are growing exponentially and in this article we have reviewed nine specialized allergen databases and identified data sources related to protein allergens contained in general purpose molecular databases.
Nikolai Petrovsky +6 more
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1998
Publisher Summary This chapter briefly outlines the development of allergens focusing on identification of allergy and its mechanisms, on the relevance of allergen in the pathogenesis of asthma, and on increased prevalence of the condition(s). Allergy, which is type I IgE-mediated sensitization and sequelae to predominantly inhaled allergens, has ...
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Publisher Summary This chapter briefly outlines the development of allergens focusing on identification of allergy and its mechanisms, on the relevance of allergen in the pathogenesis of asthma, and on increased prevalence of the condition(s). Allergy, which is type I IgE-mediated sensitization and sequelae to predominantly inhaled allergens, has ...
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Allergenic characteristics of a modified peanut allergen
Molecular Nutrition & Food Research, 2005Attempts to treat peanut allergy using traditional methods of allergen desensitization are accompanied by a high risk of anaphylaxis. The aim of this study was to determine if modifications to the IgE-binding epitopes of a major peanut allergen would result in a safer immunotherapeutic agent for the treatment of peanut-allergic patients.
J. Steven Stanley +9 more
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JAMA: The Journal of the American Medical Association, 1987
ALLERGEN immunotherapy is the process by which increasing doses of allergen are injected subcutaneously over time as a treatment to prevent allergic symptoms that usually occur on exposure to allergen. The effects of this therapy on the immunologic processes ascribed to allergic responses have been studied in great detail.
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ALLERGEN immunotherapy is the process by which increasing doses of allergen are injected subcutaneously over time as a treatment to prevent allergic symptoms that usually occur on exposure to allergen. The effects of this therapy on the immunologic processes ascribed to allergic responses have been studied in great detail.
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From Allergen Extracts to Allergen Genes and Allergen Molecules
2015An allergen is a type of protein capable of instructing the immune system to start producing IgE antibodies. The main purpose for determining the structure of major allergens is to analyze the exposed surface areas and to map the conformational epitopes. These can be determined by experimental methods including crystallographic and NMR-based approaches
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