Results 61 to 70 of about 255,557 (363)

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

MedComm
Messenger RNA (mRNA) vaccines have revolutionized infectious disease prevention and cancer immunotherapy due to their rapid development, potent immunogenicity, and flexible design.
Xiaochi Li, Junli Li, Jiazheng Wei, Weixin Du, Cheng Su, Xiaobin Shen, Aihua Zhao, Miao Xu   +7 more
doaj   +1 more source

The Diversity in Dust Fungal Spores Concentration at Four Districts of Al-Najaf Environment and their Potential Correlation with Asthma

Journal of Pure and Applied Microbiology, 2019
Fungal spores are biological molecules that are widespread in the indoor and outdoor air. Several types of the very common fungal spores are known as allergens, with the potential to cause respiratory illnesses by increasing the aggravation of asthma and
Noor I. Nasser, Maysoon K. Al-Hadrawi, Salam A. Oleiwi, Ahmed Abdulhasan Mohsin   +3 more
doaj   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

The Impact of Animal Models and Strain Standardization on the Evaluation of Tuberculosis Vaccine Efficacy

Vaccines
Tuberculosis (TB) remains one of the most significant challenges to global public health. Vaccine development is a critical strategy for the prevention and control of TB.
Jiazheng Wei, Junli Li, Xiaochi Li, Weixin Du, Cheng Su, Xiaobing Sheng, Yang Huang, Jinsong Wang, Qun Niu, Guoqing Chen, Wei Tian, Aihua Zhao, Miao Xu   +12 more
doaj   +1 more source

Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma [PDF]

, 2019
Background: Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinically efficacious and safe. However, in line with the current regulatory guidance from the European Medicines Agency, allergen immunotherapy (AIT) products must ...
Bachert, Claus, Boot, Johan D, de Kam, Pieter-Jan, Džupinová, Mária, Klimek, Ludger, Kuna, Piotr, Opstelten, Dirk Jan E, Panzner, Petr, Pfaar, Oliver, van Nimwegen, Maroesja J, Yu, Donghui   +10 more
core   +2 more sources

Peanut allergens

Molecular Immunology, 2018
Peanut allergens have the potential to negatively impact on the health and quality of life of millions of consumers worldwide. The seeds of the peanut plant Arachis hypogaea contain an array of allergens that are able to induce the production of specific IgE antibodies in predisposed individuals.
Palladino, Chiara, Breiteneder, Heimo
openaire   +2 more sources

ALLERGEN STANDARDIZATION [PDF]

Biomedical Papers, 2000
The article summarises current knowledge about the preparation and standardisation of treatment and diagnosis of allergies. It summarises the basic conceptions, units, methods and conditions for preparation, conservation and the storage of allergens. The article is especially orientated towards grass pollen.
S, Hradilová, E, Weigl, M, Raska
openaire   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Detecting soybean and milk in dairy and soy products with post-PCR high resolution melting assays

Czech Journal of Food Sciences, 2020
We have developed and validated post-PCR (polymerase chain reaction) high resolution melting (HRM) based assays that allow identifying the presence of two major allergenic foods - soybean and bovine milk - in food products.
Tereza Sovová, Barbora Křížová, Ladislav Kučera, Jaroslava Ovesná   +3 more
doaj   +1 more source