Results 141 to 150 of about 211,796 (270)

Subcutaneous Allergen Immunotherapy With Thermosensitive Hydrogel and Recombinant Birch Pollen Allergen Variant, a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
A Phase 1, randomised, placebo‐controlled, dose‐escalation trial was performed with 30 birch pollen allergic subjects treated with DM‐101PX, that contains a recombinant hypoallergenic variant of Bet v 1 formulated with poloxamer 338 thermosensitive hydrogel.
Anna Nilson, Patricia Couroux, Jaana Haka, Silja Halme, Pekka Mattila, R. J. Joost van Neerven, Rolien Pels‐Rijcken, Janneke Ruinemans‐Koerts, Yvonne Schmidt‐Hieltjes, Anne Marie Salapatek, Kati Sallinen, Kristiina Takkinen, Daphne Tsitoura, Dirk‐Jan Opstelten, Juha Rouvinen   +14 more
wiley   +1 more source

Intralymphatic allergen-specific immunotherapy

, 2018
An emerging method for allergen-specific immunotherapy is intralymphatic placement, which only requires three injections with intervals of four weeks. In this review, we summarise available evidence on clinical safety, biological efficacy and therapeutic
Schollert, Niels-Erik Harbo, Flader Skov, Peter Nytofte, Homøe, Preben, Næraa, Sara Haunstrup   +3 more
core   +1 more source

Allergen immunotherapy: routes, safety,efficacy, and mode of action

, 2013
Jillian Leigh Hochfelder, Punita PondaDivision of Allergy and Immunology, North Shore–Long Island Jewish Health System, New Hyde Park, NY, USAAbstract: Allergic rhinitis, allergic conjunctivitis, and allergic asthma have been steadily increasing in
Ponda P, Hochfelder JL
core  

Clinical Evaluation of Allergen Immunotherapy for Allergic Asthma. [PDF]

Biologics
Catamerò F, Foti Randazzese S, Caimmi D, Paoletti G, Canonica GW, Heffler E, Ledda AG, Del Giacco S, Costanzo GAML, Guida G, Ricciardolo FLM, Bertolini F, Poto R, Chan R, Varricchi G, Giovannini M.   +15 more
europepmc   +1 more source

Tryptase Locus Variation Contributes to Normal‐Range Basal Serum Tryptase Variability and Is Associated With Anaphylaxis

Clinical &Experimental Allergy, EarlyView.
Tryptase locus variation explains normal‐range baseline serum tryptase differences and is associated with Hymenoptera venom anaphylaxis, independent of clonal mast cell disease and HαT. ABSTRACT Background Increased basal serum tryptase level (BST) is associated with anaphylaxis.
Manca Svetina, Jonathan J. Lyons, Peter Kopač, Julij Šelb, Mitja Košnik, Matija Rijavec, Peter Korošec   +6 more
wiley   +1 more source

Recent advances in allergen immunotherapy. [PDF]

Chin Med J (Engl)
Fu W, Zheng Y, Chen H, Dong X, Li W, Liang H, Chen S, Akdis CA, Gao Y.   +8 more
europepmc   +1 more source

Allergen Immunotherapy and 36-Month Allergic Respiratory Disease Trajectories: A Target-Trial. [PDF]

Immun Inflamm Dis
Gonzalez-Uribe V, Moreno-Castro S, Cardoso-Perez V, Mares-Mateos DA, Paez-Reyes M, Prieto-Gomez J, Martinez-Tenopala R, Alvarez PB.   +7 more
europepmc   +1 more source

Beyond IgE blocking: Reframing allergen immunotherapy through innate immune regulation. [PDF]

World Allergy Organ J
Taketomi EA.
europepmc   +1 more source

Algorithms of Patient Selection for Allergen Immunotherapy. [PDF]

Allergy
Zieglmayer UP, Arasi S, Eiwegger T, Jakob T, Klimek L, Ollert M.   +5 more
europepmc   +1 more source

Peanut‐Specific IgG4 mAbs Promote Regulatory Immune Responses Ex Vivo and Improve Oral Immunotherapy in Mice

Clinical &Experimental Allergy, EarlyView.
Allergen‐specific IgG4 mAbs were shown to block facilitated IgE binding to B cells and redirect allergens towards myeloid APC, leading to increased IL‐10 production in vitro. In combination with oral AIT, the mAbs inhibited mast cell activation and sustained allergen‐specific IgG4 levels in an in vivo model of peanut allergy. ABSTRACT Background Peanut
Pascal Gasser, Alex A. J. Overman, Mojtaba Porbahaie, Chiara Arena, Juliane Konrad, Renate Repke, Sandra Götschi, Dimitri Bieli, Tiziana Sonati, Alcide Barberis, Niccolò Pengo, R. J. Joost van Neerven, Natascha Wuillemin   +12 more
wiley   +1 more source