Results 161 to 170 of about 17,547 (207)
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Updates on Databases of Allergens and Allergen-Epitopes
2023The increasing prevalence of allergic diseases is of great public health concern. Environmental and food allergens are the major triggers of allergic diseases via respiratory or gastrointestinal routes, respectively. A major setback in the clinical management of allergies is the unavailability of purified allergens required for diagnostic purposes ...
Rajat Kanti, Sarkar +3 more
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Factors Influencing the Allergenicity and Adjuvanticity of Allergens
Immunotherapy, 2011IgE-mediated allergic disorders affect up to 25% of the population in industrialized countries and result in a Th2-polarized immune response to innocuous environmental proteins, so-called allergens. Among a large number of proteins to which humans are exposed to, only a minute fraction are allergens.
Stephan, Deifl, Barbara, Bohle
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Standardized allergen extracts for allergen immunotherapy
Allergy and Asthma Proceedings, 2022Nineteen U.S. allergen extracts were standardized by the U.S. Food and Drug Administration (FDA) between 1987 and 1998, including of two house-dust mites, short ragweed, cat hair and cat pelt, seven temperate and one southern grass, and six Hymenoptera venom preparations. Relevant literature was reviewed.
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Allergen databases and allergen semantics
Regulatory Toxicology and Pharmacology, 2009The efficacy of any specific bioinformatic analysis of the potential allergenicity of new food proteins depends directly on the nature and content of the databases that are used in the analysis. A number of different allergen-related databases have been developed, each designed to meet a different need.
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Cockroach Allergens: Function, Structure and Allergenicity
Protein & Peptide Letters, 2007Cockroach allergy is a widespread health problem in the world, associated with the development of asthma. The German and American cockroach species are important producers of a wide variety of allergens. Knowledge of their structure and function contributes to understand their role in allergy and to design tools for diagnosis and immunotherapy.
A, Pomés +4 more
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Allergens and Allergen Immunotherapy
2020Basics Allergen Immunotherapy in a Historical Perspective David Fitzhugh, Sheldon G. Cohen, and Richard Evans III (deceased) Definition of an Allergen (Immunobiology) Malcolm N. Blumenthal and Lauren Fine Allergen Nomenclature Heimo Breiteneder and Martin D. Chapman Immunological Responses to Subcutaneous Allergen Immunotherapy Mohamed H.
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Allergenic characteristics of a modified peanut allergen
Molecular Nutrition & Food Research, 2005Attempts to treat peanut allergy using traditional methods of allergen desensitization are accompanied by a high risk of anaphylaxis. The aim of this study was to determine if modifications to the IgE-binding epitopes of a major peanut allergen would result in a safer immunotherapeutic agent for the treatment of peanut-allergic patients.
Nina, King +9 more
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Allergen-Specific Immunotherapy with Recombinant Allergens
2011Subcutaneous immunotherapy is a well-documented treatment of allergic rhinitis and asthma. The major limitation is the risk of anaphylactic side effects. The documentation of clinical efficacy is based on crude allergenic extracts sometimes containing varying amounts of individual allergens including allergens to which the patient may not be sensitized.
G, Pauli, Hans-Jørgen, Malling
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Allergen immunotherapy with cat allergen peptides
Springer Seminars in Immunopathology, 2004Desensitising therapy for allergic diseases has changed little over almost a century of practice. Administration of increasing doses of extracts of allergen source material has been shown to be reproducibly effective when patients are carefully selected and appropriate concentrations of allergen employed.
A Barry, Kay, Mark, Larché
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Current Allergy and Asthma Reports, 2001
Allergen immunotherapy plays an important role in the treatment of allergic diseases and asthma. This article is a brief review of the current approaches, including patient and allergen selection, routes of administration, and use of standardized allergen vaccines.
R E, Esch, J, Portnoy
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Allergen immunotherapy plays an important role in the treatment of allergic diseases and asthma. This article is a brief review of the current approaches, including patient and allergen selection, routes of administration, and use of standardized allergen vaccines.
R E, Esch, J, Portnoy
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