Results 31 to 40 of about 163,346 (259)

Uncovering the secretes of allergic inflammation [PDF]

Journal of Clinical Investigation, 2020
Allergic asthma is a chronic inflammatory lung disease associated with increased cytokine secretion. Aspects of airway inflammation are also linked to a common genetic variant that corresponds to the small GTPase, Rab27, a protein involved in vesicular trafficking in immune cells.
Michael Brusilovsky, Mark Rochman, Nurit P. Azouz, Lydia E. Mack, Marc E. Rothenberg   +4 more
openaire   +2 more sources

Markers of endothelial glycocalyx dysfunction in Clarkson disease

Journal of Translational Medicine, 2022
Background Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition marked by transient, relapsing-remitting episodes of systemic microvascular hyper-permeability, which ...
Zhihui Xie, Magne Børset, Kjell Svéen, Ole Wilhelm Bøe, Eunice C. Chan, Justin B. Lack, Katherine M. Hornick, Franco Verlicchi, A. Robin Eisch, Remo Melchio, Arkadiusz Z. Dudek, Kirk M. Druey   +11 more
doaj   +1 more source

Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma

Journal of Fungi, 2020
We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the ...
Kirk M. Druey, Morgan McCullough, Ramaswamy Krishnan   +2 more
doaj   +1 more source

Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma

EBioMedicine, 2017
In asthma, mucus hypersecretion is thought to be a prominent pathological feature associated with widespread mucus plugging. However, the current treatments for mucus hypersecretion are often ineffective or temporary. The potential therapeutic targets of
Xing Wang, Xiaoqiong Yang, Yin Li, Xiaoyun Wang, Yun Zhang, Xi Dai, Bin Niu, Juan Wu, Xiefang Yuan, Anjie Xiong, Zhigang Liu, Nanshan Zhong, Min Wu, Guoping Li   +13 more
doaj   +1 more source

Allergic Inflammation—Innately Homeostatic [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
Allergic inflammation is associated closely with parasite infection but also asthma and other common allergic diseases. Despite the engagement of similar immunologic pathways, parasitized individuals often show no outward manifestations of allergic disease.
Cheng, Laurence E, Locksley, Richard M
openaire   +4 more sources

Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy

Frontiers in Immunology, 2020
Toll-like receptors (TLRs) are essential components of innate immunity and provide defensive inflammatory responses to invading pathogens. Located within the plasma membranes of cells and also intracellular endosomes, TLRs can detect a range of pathogen ...
Max E. Kirtland, Max E. Kirtland, Daphne C. Tsitoura, Stephen R. Durham, Stephen R. Durham, Mohamed H. Shamji, Mohamed H. Shamji   +6 more
doaj   +1 more source

Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases

Cells, 2022
Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)
Ken Fukuda, Waka Ishida, Tatsuma Kishimoto, Isana Nakajima, Yusaku Miura, Tamaki Sumi, Kenji Yamashiro   +6 more
doaj   +1 more source

Prediction of lung adenocarcinoma prognosis and clinical treatment efficacy by telomere-associated gene risk model

Discover Oncology
Background The most prevalent cause of cancer-related death in China and across the globe is lung adenocarcinoma (LUAD). Telomere shortening (TS) has been found to contribute to the development of LUAD.
Yan Jiang, Jun Liu, Bi Pan, Siping Yu, Chunyan Hu, Qiancheng Li, Hong Cheng, Ling Chen, Min Jiang, Die Xu, Chuanhui Wang, Jie Yan   +11 more
doaj   +1 more source

TGF-β3 Promotes MUC5AC Hyper-Expression by Modulating Autophagy Pathway in Airway EpitheliumResearch in context

EBioMedicine, 2018
Mucus secretion accumulation in the airways may act as a contributing factor for the development of airflow limitation in severe fetal asthma patients. Accumulated evidences showed that transforming growth factor beta (TGF-β) plays a regulatory role in ...
Yun Zhang, Hongmei Tang, Xiefang Yuan, Qin Ran, Xiaoyun Wang, Qi Song, Lei Zhang, Yuhuan Qiu, Xing Wang   +8 more
doaj   +1 more source

Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. [PDF]

PLoS ONE, 2016
Although keratinocyte-derived neuropeptide neuromedin U (NMU) mediates the proinflammatory effects of innate-type mast cell activation, no information is available on the physiological roles.
Yoshiko Mizukawa, Takaaki Doi, Yoshimi Yamazaki, Akihiko Kudo, Tetsuo Shiohara   +4 more
doaj   +1 more source