Results 321 to 330 of about 1,143,531 (409)

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Eosinophil ETosis in severe non-IgE-mediated gastrointestinal food allergy, a neonatal necrotizing enterocolitis: A case report. [PDF]

Asia Pac Allergy
Imaide A, Taniuchi S, Dohi S, Mitomori M, Gouma M, Enomoto M, Nishino M, Yamada Y, Moritoki Y, Ueki S, Okizuka Y.   +10 more
europepmc   +1 more source

Steap4 Promotes Senile Osteoporosis via Fe2+‐ROS/C/EBPβ Feedback‐Driven Ferroptosis and Adipogenesis in Senescent BMSCs

Advanced Science, EarlyView.
Senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)‐dependent metalloreductase that reduces Fe3+ to Fe2+.
Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang   +9 more
wiley   +1 more source

Global trend of food-induced anaphylaxis: Up to date. [PDF]

Pediatr Allergy Immunol
Leung AS, Estrada-Reyes E, Goto K, Huang CH, Li JM, Nagarajan SA, Ranasinghe T, Sato S, Srisuwatchari W, Zepeda-Ortega B, Tham EH.   +10 more
europepmc   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

A Cross-Sectional Survey of Dentists on Antibiotic Prescribing and Allergy Management in Oral Surgery. [PDF]

Oral Health Prev Dent
Golchini P, Behkar S, Kocamaz ÖF, Altundoğan S.   +3 more
europepmc   +1 more source

Ultra-processed food intake and food allergy in children and adolescents

Elaine Cristina de Almeida Kotchetkoff, Fabíola Isabel Suano de Souza, Daniela Neri Gama de Almeida, Talita Lemos Neves Barreto, Raquel de Deus Mendonça, Roseli Oselka Saccardo Sarni   +5 more
openalex   +2 more sources

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Food allergy severity across the world: A World Allergy Organization international survey. [PDF]

World Allergy Organ J
Arasi S, Morais-Almeida M, Martin BL, Wing-Kin Wong G, Ansotegui IJ, Ebisawa M, Custovic A, Santos A, Nowak-Wegrzyn A, Stoddart A, Deschildre A, Cianferoni A, Muraro A, DunnGalvin A, Vickery B, Venter C, Jones C, Mazzuca C, Warren C, Munblit D, Peden DB, Fleischer D, Hossny E, Roberts G, Szajewska H, Brough HA, Sublett JL, Bernstein JA, Ortega-Martell JA, Wang LL, Tanno LK, Caraballo L, Chikhladze M, Podestà M, Shaker MS, Guzmán Meléndez MA, Said M, Vazquez-Ortiz M, Bozzola M, Greenhawt M, Levin M, Lozano MÁ, Papadopoulos NG, Monge Ortega OP, Turner PJ, Kauppi P, Giavina-Bianchi P, Rouadi PW, Bégin P, Eigenmann P, Gómez RM, Boyle RJ, Gupta RS, Sindher SB, Chinthrajah RS, Winders T, Nurmatov U, Cardona V, Chang YS, Gerdts J, Rapillo R, Del Guidice MM, Patella V, Fiocchi A, Dahdah L.   +64 more
europepmc   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source