Results 41 to 50 of about 2,550 (172)

Pre-existing Alloreactive T and B Cells and Their Possible Relevance for Pre-transplant Risk Estimation in Kidney Transplant Recipients

Frontiers in Medicine, 2020
In allogeneic transplantation, genetic disparities between patient and donor may lead to cellular and humoral immune responses mediated by both naïve and memory alloreactive cells of the adaptive immune system.
Gonca E. Karahan, Frans H. J. Claas, Sebastiaan Heidt   +2 more
doaj   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Alloantibodies and Drug-Induced Immune Hemolytic Anemia in Liver Transplantation

, 2011
Red blood cell alloantibodies can cause severe delayed hemolysis, despite immunosuppression which they receive posttransplantation. A female patient with Hepatitis C-related chronic liver disease reported to our center for liver transplantation.
Surekha Devi Allanki
core   +1 more source

Identification of feline erythrocyte antigen 6 and lack of alloimmunization to feline erythrocyte antigen 4 in cats

Journal of Veterinary Internal Medicine
Background New feline erythrocyte antigens (FEAs) have been described based on the presence of naturally occurring alloantibodies (NOAb), but their immunogenicity and clinical relevance are poorly understood.
Thomas Ternisien, Florian Azoulay, Mohammad Y. Bangash, Marie‐Claude Blais   +3 more
doaj   +1 more source

Survey of Blood Groups DEA 1, DEA 4, DEA 5, Dal, and Kai 1/Kai 2 in Different Canine Breeds From a Diagnostic Laboratory in Germany

Frontiers in Veterinary Science, 2020
More than twelve blood group systems have been described in dogs, but little is known about their distribution frequencies within breed populations. Here, we report on an extensive typing survey carried out using available reagents and either established
Anne K. Ebelt, Sonja Fuchs, Corinna Weber, Elisabeth Müller, Urs Giger   +4 more
doaj   +1 more source

Autoimmune neutropenia in children: Test cells versus beads and a role for pro‐LL‐37 and absolute neutrophil count

British Journal of Haematology, EarlyView.
A comparison between bead‐based and cell‐based assays for autoantibody detection in childhood neutropenia revealed substantial discordance between platforms. Bead‐based methods should be complemented with cell‐based methods for optimal diagnostic sensitivity. Incorporating pro‐LL‐37 and ANC measurements into the clinical workup of childhood neutropenia
Paul Ratcliffe, Alexandra Haara Löfstedt, Mikael Sundin, Petter Höglund   +3 more
wiley   +1 more source

Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease

Frontiers in Immunology, 2020
Prognostic, diagnostic or predictive biomarkers are urgently needed for assessment of chronic graft-versus-host disease (cGvHD), a major risk for patients undergoing allogeneic hematopoietic stem cell transplantation.
Rachel E. Crossland, Francesca Perutelli, Katarzyna Bogunia-Kubik, Nuala Mooney, Nina Milutin Gašperov, Maja Pučić-Baković, Hildegard Greinix, Daniela Weber, Ernst Holler, Dražen Pulanić, Daniel Wolff, Anne M. Dickinson, Marit Inngjerdingen, Magdalena Grce   +13 more
doaj   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Prevalence of Rhesus C and D Alloantibodies among Rhesus-Negative Women of Child Bearing Age at a Tertiary Hospital in South-West Nigeria [PDF]

, 2020
Background: A major cause of hemolytic disease of the fetus and newborn (HDFN) is an incompatibility of the Rhesus (Rh) blood group between the mother and fetus.
John-Olabode, S., Okunade, K., Olorunfemi, G., Otomewo, L., Ajie, I.   +4 more
core   +1 more source

Evaluation of point‐of‐care versus laboratory antiglobulin‐enhanced major crossmatch testing in cats

Journal of Small Animal Practice, EarlyView.
Objectives It is recommended that all cats, regardless of transfusion history, undergo major crossmatch prior to blood product administration to decrease the likelihood of immunological transfusion reactions. A reliable and user‐friendly point‐of‐care crossmatch test would help make crossmatch testing more accessible.
S. L. Blois, A. J. Collier, S. Sanz, I. Chun   +3 more
wiley   +1 more source