Results 101 to 110 of about 52,858 (307)

Phenotypic characteristics of diabetic neuropathic pain and factors associated in patients with Diabetes Mellitus‐type 2

Journal of Diabetes Investigation, EarlyView.
Four phenotypic groups of patients with diabetic neuropathic pain were found. Intensity, duration of pain, and the level of anxiety were the factors associated with belonging to the groups with worse characteristics. ABSTRACT Aims/Introduction To identify subgroups of patients with diabetic neuropathic pain according to their phenotypic characteristics
Helena De Sola, María Dueñas, Inmaculada Failde, Jenifer Palomo‐Osuna, Cristina Naranjo, Alejandro Salazar   +5 more
wiley   +1 more source

The effects of greater occipital nerve block and trigger point injection on brush allodynia and pain in migraine [PDF]

, 2005
Objective: To evaluate the effect of GONB, with or without trigger point injection (TPI), on dynamical mechanical (brush) allodynia (BA) and on head pain in migraine.
Ashkenazi, Avi, Young, William B.
core   +2 more sources

Mind the GAPS: Glia associated with psychological stress

Journal of Neuroendocrinology, EarlyView.
Abstract Glial cells are an integral component of the nervous system, performing crucial functions that extend beyond structural support, including modulation of the immune system, tissue repair, and maintaining tissue homeostasis. Recent studies have highlighted the importance of glial cells as key mediators of stress responses across different organs.
Niklas Blank, Molly Weiner, Shaan Patel, Sarah Köhler, Christoph A. Thaiss   +4 more
wiley   +1 more source

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. [PDF]

, 2020
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Basbaum, Allan I, Braz, Joao M, Guan, Zhonghui, Hamel, Katherine A, Leff, Jacqueline, Liu, Hongju, Morvan, Maelig G, Yu, Stephen, Yu, Xiaobing   +8 more
core   +1 more source

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Richardson, Denise   +4 more
core   +2 more sources

Administration of the Sleep‐Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia

Journal of Sleep Research, EarlyView.
ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch, Angelo V. Colmenero, Alejandra Mondino, Graciela Mentz, Steven E. Harte, Giancarlo Vanini   +5 more
wiley   +1 more source

Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action. [PDF]

, 2019
Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers an implantable, non-pharmacologic treatment for patients with intractable chronic pain conditions. Chronic pain is a widely heterogenous syndrome with regard to
Baker, Dewleen G, Caylor, Jacob, Cui, Christina, Huang, Charles, Huang, Mingxiong, Lerman, Imanuel, Narouze, Samer, Ramesh, Rao, Reddy, Rajiv, Simmons, Alan, Souza, Dmitri, Vallejo, Ricardo, Yin, Sopyda   +12 more
core  

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice [PDF]

, 2012
Progranulin haploinsufficiency is associated with frontotemporal dementia in humans. Deficiency of progranulin led to exaggerated inflammation and premature aging in mice.
Albuquerque, Boris, Ding, Aihao, Häussler, Annett, Lim, Hee-Young, Myrczek, Thekla, Tegeder, Irmgard   +5 more
core   +1 more source

Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain : a systematic review [PDF]

, 2015
Background: Chronic neck pain is a common problem with a poorly understood pathophysiology. Often no underlying structural pathology can be found and radiological imaging findings are more related to age than to a patient's symptoms.
Bramer, Wichor, Cagnie, Barbara, Danneels, Lieven, Dolphens, Mieke, Kregel, Jeroen, Kuipers, Mandy, Malfliet, Anneleen, Meeus, Mira, Nijs, Jo, Roussel, Nathalie   +9 more
core   +1 more source

Chemotherapy‐Induced Neuropathy Affecting the Gastrointestinal Tract

Neurogastroenterology &Motility, EarlyView.
Chemotherapy (with/without immunotherapy/radiotherapy) may induce neurotoxic effects on the gastrointestinal innervation. Chemotherapy‐induced enteric neuropathy (CIEN) and, probably, neurotoxicity affecting the extrinsic innervation of the gut and the brain underlie the frequent and impactful gut dysfunctions and brain–gut axis (BGA) disorders ...
Gema Vera, Kulmira Nurgali, Raquel Abalo
wiley   +1 more source