The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. [PDF]
, 2015 BackgroundMechanical pain hypersensitivity associated with physical trauma to peripheral nerve depends on T-helper (Th) cells expressing the algesic cytokine, interleukin (IL)-17A.
Angert, Mila +9 more
core +3 more sources
TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha +9 more
wiley +1 more source
Dopamine and prolactin in migraine: Mechanisms and potential therapeutic targets
Journal of Neuroendocrinology, EarlyView.Prolactin and dopamine modulate migraine‐relevant trigeminal pathways. Hyperprolactinemia is associated with migraine‐like headache, and preclinical studies show that prolactin enhances trigeminal excitability, particularly in females. Dopamine inhibits prolactin release and may also directly suppress trigeminovascular activity via D2 receptors in the ...
Astrid Johannesson Hjelholt +3 more
wiley +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch +5 more
wiley +1 more source
Molecules, 2015 Harpagophytum procumbens (H. procumbens), also known as Devil’s Claw, has been used to treat a wide range of pathological conditions, including pain, arthritis and inflammation.
Carmela Parenti +5 more
doaj +1 more source
Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study [PDF]
, 2008 <b>Objective</b>: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain.
Frank, B. +4 more
core +2 more sources
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT There has been a growing interest in the use of cannabinoids in horses in recent years. Several studies have reported on the pharmacokinetics of cannabidiol (CBD) in horses. However, cannabidiolic acid (CBDA) has received less attention, despite limited evidence suggesting clinically beneficial effects in other species.
Carl Ekstrand +5 more
wiley +1 more source
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
core +2 more sources
The Sympathetic Nervous System Contributes to Capsaicin-Evoked Mechanical Allodynia But Not Pinprick Hyperalgesia in Humans [PDF]
, 1996 Maywin Liu +4 more
openalex +1 more source
Somatosensory and nociceptive changes in chronic post-stroke shoulder pain [PDF]
, 2008 Preliminary results from a cross-sectional study that investigated the relation between the presence of post-stroke shoulder pain and somatosensory and nociceptive changes are presented.
Buitenweg, J.R. +5 more
core +1 more source