Results 101 to 110 of about 57,089 (325)

Neuromusculoskeletal ultrasound examination in Nicolau syndrome

PM&R, EarlyView.
Beytullah Yazar, Abdullah Emre Uğur, Mustafa Güngör Albayrak, Levent Özçakar   +3 more
wiley   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients. [PDF]

, 2020
ObjectivesTo evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.MethodsIn a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen ...
Abouzari, Mehdi, Djalilian, Hamid R, Ghavami, Yaser, Goshtasbi, Khodayar, Lin, Harrison W, Parker, Erica M, Sarna, Brooke, Tan, Donald   +7 more
core  

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. [PDF]

, 2018
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and dose-limiting side effect of cancer treatment that affects millions of cancer survivors throughout the world and current treatment options are extremely limited by their side effects ...
Mackie, Ken, Marty, Vincent N, Mulpuri, Yatendra, Munier, Joseph J, Schmidt, Brian L, Seltzman, Herbert H, Spigelman, Igor   +6 more
core   +1 more source

Lack of evidence for sprouting of Aβ afferents into the superficial laminas of the spinal cord dorsal horn after nerve section [PDF]

, 2003
The central arborizations of large myelinated cutaneous afferents normally extend as far dorsally as the ventral part of lamina II in rat spinal cord. Woolf et al. (1992) reported that after nerve injury some of these afferents sprouted into lamina I and
Hughes, D.I., Riddell, J.S., Scott, D.T., Todd, A.J.   +3 more
core   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats

Molecules, 2015
Harpagophytum procumbens (H. procumbens), also known as Devil’s Claw, has been used to treat a wide range of pathological conditions, including pain, arthritis and inflammation.
Carmela Parenti, Giuseppina Aricò, Santina Chiechio, Giulia Di Benedetto, Rosalba Parenti, Giovanna M. Scoto   +5 more
doaj   +1 more source

Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. [PDF]

, 2014
To investigate a potential mechanism underlying trigeminal nerve injury-induced orofacial hypersensitivity, we used a rat model of chronic constriction injury to the infraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel α2δ1 ...
Kim, Doo-Sik, Li, Kang-Wu, Lin, Bin, Luo, Z David, Sharp, Kelli, Steward, Oswald, Yu, Yanhui Peter, Zhou, Chunyi   +7 more
core   +1 more source