Results 121 to 130 of about 41,646 (248)
The Journal of Physiology, EarlyView.Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez +7 more
wiley +1 more source
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source
Contact lenses, migraine, and allodynia
, 2016 Clinical trials and electrophysiologic studies demonstrated increased perceptual sensitivity in patients suffering from migraines. At least, one triggering factor is described in 85% of migraine patients.
Baykara Mehmet +5 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise +2 more
wiley +1 more source
Frontiers in Pain ResearchIntroductionBiological aging and sex interact to shape systemic metabolism, yet their role in chronic pain resolution remains unexplored. We hypothesized that metabolic resilience—the ability to flexibly switch fuel sources and maintain energy ...
Sara Marinelli +15 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar +3 more
wiley +1 more source
A study of spinal prostaglandins in experimental allodynia
, 2001 Cumulative evidence indicates that the release of spinal prostaglandins (PGs) is increased in hyperalgesia and persistent pain states following peripheral inflammation or injury, events that are associated with repetitive C-fiber stimulation.
Zhang, Zizhen
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili +6 more
wiley +1 more source
European Journal of Pain, Volume 30, Issue 9, October 2026.ABSTRACT Background Chronic pain affects up to 30% of pregnant individuals globally and substantially impairs maternal well‐being. The prevalence and contributing factors of de novo chronic pain in pregnancy (DNPAP) remain poorly studied, with previous chronic pain rarely distinguished from newly arising pain.
Bruna H. Micheletti +10 more
wiley +1 more source
Deep Learning‐Based Quantification of Spontaneous Pain Behaviours in Mice
European Journal of Pain, Volume 30, Issue 9, October 2026.ABSTRACT Background Accurate evaluation of pain‐related behaviours in rodent models is crucial for elucidating pain mechanisms and assessing the efficacy of novel analgesic compounds. Traditional nociceptive assays primarily measure evoked responses, which have limited translational relevance since spontaneous pain is the predominant symptom in pain ...
Michele Zanoletti +9 more
wiley +1 more source