Results 121 to 130 of about 34,932 (289)

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache [PDF]

, 2023
Erika Liktor‐Busa, Aidan A. Levine, Seph M. Palomino, Simar Singh, Jared Wahl, Todd W. Vanderah, Nephi Stella, Tally M. Largent‐Milnes   +7 more
openalex   +1 more source

The rs10781468 Genetic Polymorphism of the Gαq (GNAQ) Gene Is Associated With Responsiveness to Opioid Analgesics in Patients With Postoperative and Cancer Pain: An Exploratory Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
In our exploratory hypothesis‐generating study using patients with postoperative pain and cancer pain, for rs10781468 in the GNAQ gene, the minor allele was associated with reduced opioid consumption and an increased pain threshold. ABSTRACT Background G protein–coupled receptors, the largest class of cell surface receptors, are ubiquitously expressed ...
Hiroaki Owada, Daisuke Nishizawa, Tsutomu Mieda, Miki Tsujita, Hideyuki Nakagawa, Shigeki Yamaguchi, Rikuhei Tsuchida, Yaeko Yokoshima, Akira Kitamura, Masakazu Hayashida, Ken‐ichi Fukuda, Tatsuya Ichinohe, Kazutaka Ikeda, Makoto Kurano, Masahiko Sumitani, Kanji Uchida   +15 more
wiley   +1 more source

The Erasmus—Polyneuropathy Symptom Score for the Screening of Chronic Axonal Polyneuropathy: A Validation Study

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Chronic axonal polyneuropathy is a common disorder that often remains undiagnosed. Early detection may enhance treatment of underlying risk factors and prevent long‐term complications. The Erasmus‐Polyneuropathy symptom score (E‐PSS) is a simple and rapid screening tool, consisting of six questions (score ranges 0–14). This
Noor E. Taams, Merel Huijg, Frederique H. Vermeij, Krista Kuitwaard, Rens Hanewinckel, Janet de Beukelaar, Evan L. Reynolds, Brian C. Callaghan, M. Arfan Ikram, Pieter A. van Doorn   +9 more
wiley   +1 more source

Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain

Journal of Pain Research, 2017
Banulata Gopalsamy, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang ...
Gopalsamy B, Farouk AAO, Tengku Mohamad TAS, Sulaiman MR, Perimal EK   +4 more
doaj  

Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice [PDF]

, 2012
Guangyuan Li, Alexander A. Veenstra, Ramaprasad Ravichandra Talahalli, Xiaoqi Wang, Rose Gubitosi‐Klug, Nader Sheibani, Timothy S. Kern   +6 more
openalex   +1 more source

Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double‐Blind Trial

Pain Practice, Volume 26, Issue 7, September 2026.
ABSTRACT Background Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients.
Philippe Lafuma, Laurent Magaud, Amna Abichou‐Klich, Muriel Rabilloud, Julien Wegrzyn, Christian Baude, Pascal Rippert, Myriam Kaou, Julie Haesebaert, Frédéric Rongieras, Chloé Marchand, Carole Dhelens, Olivia Febvey‐Combes   +12 more
wiley   +1 more source

Targeting the endogenous cannabinoid system to treat chronic neuropathic pain

Frontiers in Pharmacology, 2014
Benjamin K Lau, Christopher W Vaughan
doaj   +1 more source

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

, 2016
José Manuel Entrena, Cristina Sánchez–Fernández, Francisco R. Nieto, Rafael González‐Cano, Sandra Yeste, Enrique J. Cobos, José M. Baeyens   +6 more
openalex   +1 more source

Elevated Serum Soluble CD163 Indicates Macrophage Activation: A Potential Biomarker for Inflammation in Complex Regional Pain Syndrome?

Pain Practice, Volume 26, Issue 7, September 2026.
ABSTRACT Background Several studies point towards the involvement of the immune system (especially the monocyte–macrophage system) in the pathophysiology of Complex Regional Pain Syndrome (CRPS), as shown by increased levels of the cytokines tumor necrosis factor (TNF)‐α and interleukin (IL)‐6.
Nadia Kriek, Krishna Bharwani, Maaike Dirckx, Dirk Stronks, Nicole Nagtzaam, Wim A. Dik, Frank Huygen   +6 more
wiley   +1 more source