Results 101 to 110 of about 41,646 (248)

Allodynia mediated by C-tactile afferents in human hairy skin

, 2011
We recently showed a contribution of low-threshold cutaneous mechanoreceptors to vibration-evoked changes in the perception of muscle pain. Neutral-touch stimulation (vibration) of the hairy skin during underlying muscle pain evoked an overall increase ...
Chelvanayagam, David K. (R14441), David K. Chelvanayagam, Nagi, Saad S. (S26466), Saad S. Nagi, Mahns, David A. (R11697), Vaughan G. Macefield, Troy K. Rubin, Rubin, Troy K. (S24873), Macefield, Vaughan G. (R11708), David A. Mahns   +9 more
core   +1 more source

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone

Frontiers in Cellular Neuroscience, 2014
A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor ...
Pierrick ePoisbeau, Florence eKeller, Florence eKeller, Maya eAouad, Nisrine eKamoun, Ghislaine eGroyer, Michael eSchumacher   +6 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats

, 2018
Jinseok Yeo,1 Sungsik Park2 1Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea; 2Department of Anesthesiology and Pain Medicine, Kyungpook ...
Park SS, Yeo JS
core  

Migraine-provoking substances evoke periorbital allodynia in mice [PDF]

, 2019
Background Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks.
Pierangelo Geppetti, Francesco De Logu, Francesco De Cesaris, Nassini, R., Malvin N. Janal, De Logu, F., Lorenzo Landini, De Cesaris, F., Landini, L., Simone Li Puma, Geppetti, P., Romina Nassini, Li Puma, S.   +12 more
core   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Case report: Treatment of burning pain and Post traumatic refractory Allodynia in foot digits, with low dose of ketamine [PDF]

Frequent simulation and irritation of NMDA receptors by glutamate mediators can lead to burning pain, allodynia and hyperalgesia, even after stopping the irritant factor.
ایمانی, فرناد, قره داغی, فرید ابوالحسن, محمدیان اردی, علی   +2 more
core  

C-tactile fibers contribute to cutaneous allodynia after eccentric exercise

, 2013
We recently showed that during acute muscle pain, C-tactile (CT) fibers mediate allodynia in healthy human subjects. In this study, we pursued the following questions: Do CTs contribute to allodynia observed in delayed onset muscle soreness (DOMS)? Is CT-
Nagi, Saad S. (R17429), Mahns, David A. (R11697), Saad S. Nagi, David A. Mahns   +3 more
core   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source