Results 131 to 140 of about 55,599 (275)

A systematic review of outcomes measured in interventional trials in people with diabetic sensorimotor polyneuropathy

open access: yesDiabetic Medicine, Volume 42, Issue 11, November 2025.
Abstract Aims Diabetic sensorimotor polyneuropathy (DSPN) is the most common chronic complication of diabetes. Heterogeneity in outcome measures across DSPN trials may have hindered the development of novel therapies. No core outcome set (COS) exists to standardise DSPN trial outcomes.
Galvin Chiam   +5 more
wiley   +1 more source

Efficacy of Combined Versus Supplementary Injection Techniques With Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta‐Analysis

open access: yesInternational Endodontic Journal, Volume 58, Issue 11, Page 1681-1710, November 2025.
ABSTRACT Background Achieving effective anaesthesia in mandibular molars with symptomatic irreversible pulpitis is challenging. Various strategies involving the inferior alveolar nerve block (IANB) have been investigated, such as supplementing with additional injections after IANB failure (SUPP) or combining injections with IANB as primary injections ...
Thanatpong Rujirawan   +2 more
wiley   +1 more source

Bedside Neuromodulation of Persistent Pain and Allodynia with Caloric Vestibular Stimulation

open access: yesBiomedicines
Background: Caloric vestibular stimulation (CVS) is a well-established neurological diagnostic technique that also induces many phenomenological modulations, including reductions in phantom limb pain (PLP), spinal cord injury pain (SCIP), and central ...
Trung T. Ngo   +9 more
doaj   +1 more source

Non‐Invasive Vagus Nerve Stimulation in Cluster Headache: A Clinical Practice Guideline

open access: yesPain Practice, Volume 25, Issue 8, November 2025.
ABSTRACT Background Cluster headache (CH) is a rare but severe primary headache disorder characterized by recurrent attacks of unilateral, typically periocular pain lasting 15 min to 3 h, accompanied by ipsilateral autonomic symptoms and restlessness or agitation.
Peter J. Goadsby   +4 more
wiley   +1 more source

Allodynia and hyperalgesia produced by specific inhibition of spinal c-fos expression: Lack of correlation with dynorphin content [PDF]

open access: bronze, 2001
Mohab Ibrahim   +5 more
openalex   +1 more source

From acute to chronic pain: tapentadol in the progressive stages of this disease entity [PDF]

open access: yes, 2017
OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity.
Coluzzi, Flaminia   +3 more
core  

Directed Self‐Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity

open access: yesAdvanced Science, Volume 12, Issue 39, October 20, 2025.
Magnetically guided bioceramic nanoparticles (“CalBots”) achieve deep dentinal tubule occlusion via directed self‐assembly under externally applied magnetic field. Various visualization techniques and a novel mouse behavioral assay indicate that CalBot‐induced plugs may reduce dentinal sensitivity, offering a promising strategy for future dentin ...
Shanmukh Peddi   +6 more
wiley   +1 more source

Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice

open access: yesAlzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Inflammatory bowel disease triggers extraintestinal manifestations, including in the central nervous system (CNS). However, the direct impact of peripheral inflammation on the CNS is largely unknown. METHODS Using a mouse model of colitis with pain and anxiety‐like behavior, we investigated the intricate pathogenic link between ...
Clara Ciampi   +20 more
wiley   +1 more source

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