Results 131 to 140 of about 57,089 (325)

False nonresponders to anti‐calcitonin gene‐related peptide monoclonal antibodies: A real‐world analysis beyond migraine frequency reduction

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Reimbursement criteria for anti‐calcitonin gene‐related peptide (CGRP) monoclonal antibodies (MAbs) typically rely on predefined reductions in monthly migraine days (MMD). However, this approach may fail to capture the full spectrum of treatment benefits, potentially leading to premature discontinuation in patients ...
Albert Muñoz‐Vendrell, Sergio Campoy‐Díaz, Patricia Díaz‐Corta, Lidia Termens, Jaume Campdelacreu, Joan Prat, Jordi Sanahuja, Mariano Huerta‐Villanueva   +7 more
wiley   +1 more source

Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene‐related peptide sensitization

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal ganglion cells (RGCs) that contain melanopsin, making them intrinsically photosensitive ...
Eric A. Kaiser, Audrey Cavanah, Geoffrey K. Aguirre, Frances E. Jensen   +3 more
wiley   +1 more source

Vaporized cannabis versus placebo for acute migraine: A randomized, double‐blind, placebo‐controlled crossover trial

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess the efficacy of cannabis for the treatment of acute migraine. Background Preclinical and retrospective studies suggest cannabinoids may be effective in migraine treatment. However, there have been no randomized clinical trials examining the efficacy of cannabinoids for acute migraine.
Nathaniel M. Schuster, Mark S. Wallace, Thomas D. Marcotte, Dawn C. Buse, Euyhyun Lee, Lin Liu, Michelle Sexton   +6 more
wiley   +1 more source

Administration of the Sleep‐Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia

Journal of Sleep Research, EarlyView.
ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch, Angelo V. Colmenero, Alejandra Mondino, Graciela Mentz, Steven E. Harte, Giancarlo Vanini   +5 more
wiley   +1 more source

Bedside Neuromodulation of Persistent Pain and Allodynia with Caloric Vestibular Stimulation

Biomedicines
Background: Caloric vestibular stimulation (CVS) is a well-established neurological diagnostic technique that also induces many phenomenological modulations, including reductions in phantom limb pain (PLP), spinal cord injury pain (SCIP), and central ...
Trung T. Ngo, Wendy N. Barsdell, Phillip C. F. Law, Carolyn A. Arnold, Michael J. Chou, Andrew K. Nunn, Douglas J. Brown, Paul B. Fitzgerald, Stephen J. Gibson, Steven M. Miller   +9 more
doaj   +1 more source

Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma‐1 and GABA_Areceptors [PDF]

, 2009
Seo‐Yeon Yoon, Dae‐Hyun Roh, Hyoung‐Sig Seo, Suk‐Yun Kang, Ho Jae Han, Alvin J. Beitz, Jang‐Hern Lee   +6 more
openalex   +1 more source

The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-Seq

, 2022
Han Zhou, Xiaosheng Yang, Chenlong Liao, Hongjin Chen, Yiwei Wu, Binran Xie, Fukai Ma, WenChuan Zhang   +7 more
openalex   +1 more source

Citral inibe a inflamação aguda e nocicepção em camundongos: o papel dos receptores TLR4 e TLR2/DECTINA-1 [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Citral (3,7-dimethyl-2,6-octadienal), um monoterpeno de cadeia aberta e principal componente bioativo do capim limão, apresenta diferentes propriedades farmacológicas, tais ...
Gonçalves, Elaine Cristina Dalazen
core  

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Intrathecal administration of Ca_v3.2 and Ca_v3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion [PDF]

, 2006
Xianjie Wen, Zhang-jun LI, Zhi‐Xin Chen, Zhiyuan Fang, Yang Chenxiang, Heng Li, Zeng Yin-ming   +6 more
openalex   +1 more source